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System for Service Workers’ Routes Planning
Mlčoch, Michal ; Bartík, Vladimír (referee) ; Hynek, Jiří (advisor)
This bachelor’s thesis deals with the issue of service requests arising in smart cities and their planning into the routes for service workers. The thesis discusses the issue of the concept of smart cities, route optimization and analysis of services providing route optimization. This work aims to create a system for planning the routes of service workers for the smart city platform developed by Logimic. The main functionality is to enable route optimization through third-party services, and the emphasis is on being able to easily change the thirdparty service providing the optimization.
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Pyrazine derivatives as potential antimycobacterial drugs II.
Mlčoch, Michal ; Doležal, Martin (advisor) ; Miletín, Miroslav (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department: Department of Pharmaceutical Chemistry and Drug Control Author: Michal Mlčoch Supervisor: Prof. PharmDr. Martin Doležal, Ph.D. Title of Diploma Thesis: Pyrazine derivatives as potential antimycobacterial drugs II. Tuberculosis has become one of the most serious health problems in the contemporary world. Mycobacteria causing this disease are more and more resistant to conventional antibiotics due to their increasing consumption. Therefore scientists all over the world work on new efficient drugs suitable for treatment of this dangerous disease. In the theoretical part of my diploma thesis, important facts and information regarding this disease and its therapy are summarized. In this work eight new compounds derived from pyrazine-2-carboxamide were synthesized. These molecules were characterized by physicochemical properties (melting temperature, log P, Clog P) and their structure was confirmed by elemental analyses, NMR and IR spectroscopy. The antituberculotic, antifungal and antibacterial activities of the prepared substances were evaluated. The results show that none of the prepared compounds has any antifungal or antibacterial activity. Only one substance (JZ-M12) is effective against M. tuberculosis, its MIC is 12,5...
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Alkylamino- Derivatives of Pyrazinamide as Potential Antituberculotic Drugs
Mlčoch, Michal ; Zitko, Jan (advisor) ; Musílek, Kamil (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department: Department of Pharmaceutical Chemistry and Drug Control Candidate: Mgr. Michal Mlčoch Supervisor: Mgr. Jan Zitko, Ph.D. Title of candidate thesis: Alkylamino- derivatives of pyrazinamide as potential antituberculotic drugs This thesis is a result of intention to prepare potential effective derivatives from pyrazinamide (PZA) structure. These results contribute to enrichment of the research of new antituberculars (antiTBC) which has been carried out at the Dpt. of Pharmaceutical Chemistry and Drug Control at the Faculty of Pharmacy in Hradec Králové. The aim of the research to produce the new effective antituberculars is supported by the contemporary state of tuberculosis in the world. This state is closely described in this thesis. Despite of decreasing number of new cases in all six WHO regions, spreading of this infectious disease is not under the control. The main reason is a resistance formation of new mycobacterial strains which can cause hardly treatable cases. The prepared substances are PZA derivatives which represent one of the most important first line drugs for tuberculosis treatment. The latest research focused on mechanism of PZA showed new information which was included in this thesis. Furthermore, some...
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Alkylamino- Derivatives of Pyrazinamide as Potential Antituberculotic Drugs
Mlčoch, Michal ; Zitko, Jan (advisor) ; Musílek, Kamil (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department: Department of Pharmaceutical Chemistry and Drug Control Candidate: Mgr. Michal Mlčoch Supervisor: Mgr. Jan Zitko, Ph.D. Title of candidate thesis: Alkylamino- derivatives of pyrazinamide as potential antituberculotic drugs This thesis is a result of intention to prepare potential effective derivatives from pyrazinamide (PZA) structure. These results contribute to enrichment of the research of new antituberculars (antiTBC) which has been carried out at the Dpt. of Pharmaceutical Chemistry and Drug Control at the Faculty of Pharmacy in Hradec Králové. The aim of the research to produce the new effective antituberculars is supported by the contemporary state of tuberculosis in the world. This state is closely described in this thesis. Despite of decreasing number of new cases in all six WHO regions, spreading of this infectious disease is not under the control. The main reason is a resistance formation of new mycobacterial strains which can cause hardly treatable cases. The prepared substances are PZA derivatives which represent one of the most important first line drugs for tuberculosis treatment. The latest research focused on mechanism of PZA showed new information which was included in this thesis. Furthermore, some...
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Pyrazine derivatives as potential antimycobacterial drugs II.
Mlčoch, Michal ; Doležal, Martin (advisor) ; Miletín, Miroslav (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department: Department of Pharmaceutical Chemistry and Drug Control Author: Michal Mlčoch Supervisor: Prof. PharmDr. Martin Doležal, Ph.D. Title of Diploma Thesis: Pyrazine derivatives as potential antimycobacterial drugs II. Tuberculosis has become one of the most serious health problems in the contemporary world. Mycobacteria causing this disease are more and more resistant to conventional antibiotics due to their increasing consumption. Therefore scientists all over the world work on new efficient drugs suitable for treatment of this dangerous disease. In the theoretical part of my diploma thesis, important facts and information regarding this disease and its therapy are summarized. In this work eight new compounds derived from pyrazine-2-carboxamide were synthesized. These molecules were characterized by physicochemical properties (melting temperature, log P, Clog P) and their structure was confirmed by elemental analyses, NMR and IR spectroscopy. The antituberculotic, antifungal and antibacterial activities of the prepared substances were evaluated. The results show that none of the prepared compounds has any antifungal or antibacterial activity. Only one substance (JZ-M12) is effective against M. tuberculosis, its MIC is 12,5...
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