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Conversion of Heršpická street to urban road
Mareček, Zdeněk ; Pavlíček,, Jan (referee) ; Všetečka, Martin (advisor)
The aim of this project is a refurbishment of the local collecting road Herspicka located in Brno, Czech republic. The goal of the project is to improve the accessibility for various transport means. The project contains design of several crossroads situated along this major road. This thesis is elaborated in a form of a technical study. The traffic flows intensity calculation was conducted on studied level crossings along the studied road.
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The importance of biosynthetic and catabolic pathway of cholesterol in inflammatory and tumor diseases
Leníček, Martin ; Vítek, Libor (advisor) ; Haluzík, Martin (referee) ; Mareček, Zdeněk (referee)
This thesis focuses on the importance of intermediate products of biosynthetic and catabolic pathway of cholesterol. The aim of the first part of the thesis is mainly to investigate, whether statins (HMG- CoA reductase inhibitors) possess antitumor properties and to compare the differences in antitumor potential of individual statins. The other part of the thesis aims at the utilization of 7α-hydroxycholest-4-en-3-one (C4), a promising marker of cholesterol 7α-monooxygenase (CYP7A1) activity and bile acid malabsorption. We demonstrated antitumor effect of statins on an experimental model of pancreatic cancer. Individual statins, however, differed significantly in their efficacy, depending on their physico-chemical properties. Our data suggests, that the most likely (but not the only) mechanism of antitumor effect of statins is decreased prenylation of signaling proteins, especially Ras protooncogene. We set up a reliable method for measurement of C4, which facilitated our research in CYP7A1 regulation. We demonstrated, that promoter polymorphism -203A>C might affect CYP7A1 activity, that diurnal variability of CYP7A1 activity might be triggered by insulin, and that insulin resistance in patients with non-alcoholic fatty liver disease impedes the feedback regulation of CYP7A1, which may lead to disease...
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Conversion of Heršpická street to urban road
Mareček, Zdeněk ; Pavlíček,, Jan (referee) ; Všetečka, Martin (advisor)
The aim of this project is a refurbishment of the local collecting road Herspicka located in Brno, Czech republic. The goal of the project is to improve the accessibility for various transport means. The project contains design of several crossroads situated along this major road. This thesis is elaborated in a form of a technical study. The traffic flows intensity calculation was conducted on studied level crossings along the studied road.
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The importance of biosynthetic and catabolic pathway of cholesterol in inflammatory and tumor diseases
Leníček, Martin ; Vítek, Libor (advisor) ; Haluzík, Martin (referee) ; Mareček, Zdeněk (referee)
This thesis focuses on the importance of intermediate products of biosynthetic and catabolic pathway of cholesterol. The aim of the first part of the thesis is mainly to investigate, whether statins (HMG- CoA reductase inhibitors) possess antitumor properties and to compare the differences in antitumor potential of individual statins. The other part of the thesis aims at the utilization of 7α-hydroxycholest-4-en-3-one (C4), a promising marker of cholesterol 7α-monooxygenase (CYP7A1) activity and bile acid malabsorption. We demonstrated antitumor effect of statins on an experimental model of pancreatic cancer. Individual statins, however, differed significantly in their efficacy, depending on their physico-chemical properties. Our data suggests, that the most likely (but not the only) mechanism of antitumor effect of statins is decreased prenylation of signaling proteins, especially Ras protooncogene. We set up a reliable method for measurement of C4, which facilitated our research in CYP7A1 regulation. We demonstrated, that promoter polymorphism -203A>C might affect CYP7A1 activity, that diurnal variability of CYP7A1 activity might be triggered by insulin, and that insulin resistance in patients with non-alcoholic fatty liver disease impedes the feedback regulation of CYP7A1, which may lead to disease...
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Use of Content Network in Online Advertising – Evaluation of its Success Factors
Krišica, Ondřej ; Stříteský, Václav (advisor) ; Mareček, Zdeněk (referee)
The thesis is concerned with a content network within the scope of online advertising and evaluation of factors of its success within online campaigns. The introductory part deals with the most common revenue models of online marketing and categorizing methods of online advertising regarding their specifics. The body of the paper describes metrics and a method of targeting applied in contemporaneous practice and furthermore introduces evaluation indicators in online marketing for content networks used in final analysis. The thesis presents and compares advertising systems for targeting in a content network. The goal of the paper is to show impact evaluation of chosen settings of advertising campaigns on their success, more specifically on possibilities of targeting and formulation of recommendations for their management.
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