National Repository of Grey Literature 3 records found  Search took 0.01 seconds. 
The danger of artifacts at detection of steroid receptors in hormonally stimulated tumours of women
Koubová, Ivana ; Kovařík, Miroslav (advisor) ; Semecký, Vladimír (referee)
- EN The main content of this thesis is to analyse results of immunohistochemical examinations of bioptic samples of breast cancer tissues. In every workplace each examination must include a determination of estrogen a progestron receptors level, antigen Ki-67 level and HER-2/neu expresion. Only on basis of these data the doctor will be able to diagnose correctly the carcinoma and choose the appropriate therapy. The examination isn't taken the same way in every workplace. It is therefore suitable to have data from different hospitals, so we could make a complete view on the problem. This thesis is focused only on data from Prague hospital Na Bulovce, but our shool workplace has already the data from other laboratories, so they can work it out additionally. In the theoretical part of this thesis we described the problem of breast carcinoma in general, we presented a list of carcinoma types and we described closer two of the most frequent - invasive ductual and invasive lobular carcinoma. We deal with these types of breast cancer in practical part. In further chapters we explain how the grading is appointed. We characterized all main markers of breast carcinoma examination and ways of performing the tests. Then we mentioned few possible causes of artifacts - ovarian cycle, intratumoral production of...

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1 Koubová, Iveta
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