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In vitro and in vivo antimicrobial effect of lasioglossins on the Candida albicans
Kašperová, A. ; Turánek, J. ; Čeřovský, Václav ; Raška, M.
Lasioglossins represent a new group of amphipathic α-helical peptides with significant antimicrobial effect on the Candida albicans. This study examines the antifungal activity of two peptides LL-III and all D-LL-III as measured by the suppression of Candida proliferation and suppression of induced morphological differentiation both in in vitro and in vivo assays. In the in vitro Candida proliferation assay, the inhibitory effect of lasioglossins LL-III and all D-LL-III was more than 70% within 24 h and more than 84% after 48 h of incubation (final concentration of either peptide was 17.5 .mu.M). Delaying of blastoconidial transition to hyphae in vitro and tendency to suppress vaginal candidiasis in experimental mice were detected.
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Analysis of Marketing Mix Tools in RAMA Bohemia, a.s.
Kasperová, Andrea ; Kozlová, Taťána (advisor) ; Lusk, Matúš (referee)
The objective of this bachelor thesis is to characterise the essence of the notion of marketing mix with the help of known techniques. In the practical part of the work the author will focus on the particular company, RAMA BOHEMIA, a. s., to analyse applications of the individual instruments of the marketing mix in the company, to assess their functioning and to propose potential measures in the case of a found drawback.
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