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Chiral Separation of Biologically Important Compounds by High-Performance Separation Methods Using Macrocyclic Antibiotics
Honetschlägerová, Marie
Chiral Separation of Biologically Important Compounds by High-Performance Separation Methods Using Macrocyclic Antibiotics Mgr. Marie Honetschlägerová-Vadinská Abstract The aim of this thesis was to study retention and enantioseparation behavior of selected biologically active compounds by high performance liquid chromatography and capillary liquid chromatography on chiral stationary phases based on glycopeptide antibiotics. The retention and enantioseleparation behavior of selected profen non-steroidal anti- inflammatory drugs (NSAIDs) on a teicoplanin aglycone (TAG) CSP in cLC under various mobile phase compositions was studied. As the chiral capillaries are not commercially available, three capillary columns, packed with TAG stationary phase using the same procedure, were tested to evaluate the repeatability and reproducibility. The cLC results for a set of profen NSAIDs were compared with the HPLC results obtained on the TAG CSPs under the identical separation conditions. The evaluation of the enantioselective performance of two commercially available teicoplanin (T) CSPs with different chiral selector (CS) coverage, i.e., Chirobiotic T and T2 was carried out for three groups of structurally diverse chiral compounds. These compounds were chosen from diverse application fields, namely amino alcohols...
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Chiral Separation of Biologically Important Compounds by High-Performance Separation Methods Using Macrocyclic Antibiotics
Honetschlägerová, Marie
Chiral Separation of Biologically Important Compounds by High-Performance Separation Methods Using Macrocyclic Antibiotics Mgr. Marie Honetschlägerová-Vadinská Abstract The aim of this thesis was to study retention and enantioseparation behavior of selected biologically active compounds by high performance liquid chromatography and capillary liquid chromatography on chiral stationary phases based on glycopeptide antibiotics. The retention and enantioseleparation behavior of selected profen non-steroidal anti- inflammatory drugs (NSAIDs) on a teicoplanin aglycone (TAG) CSP in cLC under various mobile phase compositions was studied. As the chiral capillaries are not commercially available, three capillary columns, packed with TAG stationary phase using the same procedure, were tested to evaluate the repeatability and reproducibility. The cLC results for a set of profen NSAIDs were compared with the HPLC results obtained on the TAG CSPs under the identical separation conditions. The evaluation of the enantioselective performance of two commercially available teicoplanin (T) CSPs with different chiral selector (CS) coverage, i.e., Chirobiotic T and T2 was carried out for three groups of structurally diverse chiral compounds. These compounds were chosen from diverse application fields, namely amino alcohols...
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Consumer protection on the drinking water market
Kosová, Martina ; Horová, Olga (advisor) ; Honetschlägerová, Marie (referee)
The goal of Bachelor thesis is marketing research on consumer preferences and knowledge in the field of drinking water and also analyze and compare the price of tap water and bottled water. The theoretical part describes how the consumer market with drinking water is protected in the Czech Republic. They compared the advantages and disadvantages of both types of drinking water.
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