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National Repository of Grey Literature 2 records found  Search took 0.00 seconds. 
Biochemical diagnostics of mitochondrial disorders in muscle tissue
 Bradová, Radka ; Dršata, Jaroslav (advisor) ; Novotná, Eva (referee)
Mitochondrial diseases are serious hereditary metabolic disorders caused by insufficient energy function of mitochondrion. The cause of the disorders is biogenesis and structure of oxidative-phosphorylation system (OXPHOS) fault. Mitochondrial diseases have extensive clinical implications with a very poor prognosis. Incidence of these diseases is approximately 1: 5000 and thus they ranks among one of the most common congenital metabolic disorders. Given it that treatment is still unavailable, the only way to help the affected families is properly and early find out the true cause of the mitochondrial diseases to ensure the possibility of genetic counseling in affected families. In recent years, although novel genes that are responsible for the MO are discovered, the majority of the genes causing the disease still remains unknown. The only possibility is the analysis of mitochondrial functions at the biochemical level. This thesis focuses on the analysis of biochemical parameters of mitochondrial enzymes in skeletal muscle sample. The thesis describes the biochemical diagnosis process involving the collection of tissue, isolation of mitochondria and analyses for enzymatic activity of OXPHOS complexes. Mitochondrial fraction of native muscle was isolated by the differential centrifugation. The...
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State and Perspektive of the Sales from Farmyard
 BRADOVÁ, Radka
This work deals with the sale of agricultural products directly to consumers from the farm. The aim was to evaluate the status and prospects of the yard sale and then propose measures to improve the current situation. Research for producers and consumers, which took place in 2011, showed that in direct sales from the farm are the biggest barriers legislative conditions, administration and lack of marketing communication. The customers want to buy fresh local products, they are interested in the origin of food, but they often prefer cheap food in supermarkets.
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