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Health insurance of foreigners in the Czech Republic
Žabka, Jan ; Koldinská, Kristina (advisor) ; Tomšej, Jakub (referee)
Health insurance of foreigners in the Czech Republic Abstract The main topic of this master thesis is the issue of health insurance of foreigners in the Czech Republic. Its goal is not only an analysis of the current legal regulation of this insurance, but also proposals for its possible development in the future. The thesis is focused on foreigners primarily for the reason that, while Czech citizens' access to health insurance is relatively unproblematic, in the case of foreigners there are many complications and obstacles. In the first chapter, the author first deals with foreigners who participate in the public health insurance system. In this part, he mainly draws attention to the inappropriate legal regulation, which concerns the access of persons to public health insurance, as well as to the imperfect formulation of the conditions of application of one of the coordination regulations. In the second chapter, on the other hand, the author focuses on foreigners who do not participate in public health insurance and must therefore conclude commercial health insurance for foreigners. The chapter on commercial health insurance for foreigners is divided into two subsections. The first deals with basic health insurance for foreigners and the second with comprehensive health insurance for foreigners. The...
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Study of new synthetic drugs using LC/MS/MS
Obluková, Michaela ; Žabka, Ján (advisor) ; Cvačka, Josef (referee)
In the recent years, many new substances have appeared in the drug market, which are abused for their psychoactive effect. It is used as an alternative to classical drugs (heroin, cocaine, ecstasy ect.) due to their legal status. The great concern is ineffectiveness of the current methods of toxicological screening of biological samples to identify these new compounds. The aim of my diploma thesis was to receive or expand knowledge of chemical properties of 10 standards of new psychoactive substances and its metabolites using MS/MS. Conditions for creation of precursor ions in ion source, optimization of conditions of transport of these ions to the ion trap and optimization of condition of fragments creation in the ion trap were optimized. Subsequently, fragmentation of these ions was studied systematically. Characteristic losses of neutral molecules were determined for each group of these substances which can increase the sensitivity of this method. After that, mephedrone was chosen for detailed study including the study of its metabolites using LC-MS/MS. Standard of mephedrone, spiked urine sample with mephedrone and rat urine dosed with mephedrone were studied. Mephedrone and some its metabolites were identificated in this urine sample. Information received from the investigated substances can...
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Photodissociation studies of xanthene dyes, iron(III) azido complexes and hemithioindigo molecular switches in the gas phase
Navrátil, Rafael ; Roithová, Jana (advisor) ; Žabka, Ján (referee) ; Volný, Michael (referee)
Electronic excitation triggered by the absorption of light enables numerous chemical, physical and biological processes and transformations. Accordingly, full control over the processes involving excited molecules requires an in-depth knowledge of electronic UV/vis spectra and potential energy surfaces. Unsurprisingly, most electronic spectra are acquired in the condensed phase in which molecules are dissolved and most transformations occur. However, our knowledge of excitation, transformations and processes at the level of isolated molecules is still limited, partly because such studies require unconventional experimental approaches and equipment. This Thesis describes experimental methods for recording electronic spectra of isolated molecules in the gas phase by ion spectroscopy, which combines mass spectrometry with optical spectroscopy. Using these methods, experimental factors which affect the electronic excitation and therefore the electronic spectra of ions were determined and evaluated for various fluorescent xanthene dyes, iron-containing complexes and molecular pho- toswitches. Furthermore, factors which govern photochemical processes, such as photo- oxidation, photoreduction and photoisomerization, were also analyzed in detail, with surprisingly different outcomes from previous studies...
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Study of new synthetic drugs using LC/MS/MS
Obluková, Michaela ; Žabka, Ján (advisor) ; Cvačka, Josef (referee)
In the recent years, many new substances have appeared in the drug market, which are abused for their psychoactive effect. It is used as an alternative to classical drugs (heroin, cocaine, ecstasy ect.) due to their legal status. The great concern is ineffectiveness of the current methods of toxicological screening of biological samples to identify these new compounds. The aim of my diploma thesis was to receive or expand knowledge of chemical properties of 10 standards of new psychoactive substances and its metabolites using MS/MS. Conditions for creation of precursor ions in ion source, optimization of conditions of transport of these ions to the ion trap and optimization of condition of fragments creation in the ion trap were optimized. Subsequently, fragmentation of these ions was studied systematically. Characteristic losses of neutral molecules were determined for each group of these substances which can increase the sensitivity of this method. After that, mephedrone was chosen for detailed study including the study of its metabolites using LC-MS/MS. Standard of mephedrone, spiked urine sample with mephedrone and rat urine dosed with mephedrone were studied. Mephedrone and some its metabolites were identificated in this urine sample. Information received from the investigated substances can...
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The growth of larger hydrocarbons in the ionosphere of Titan: C9Hx 2+ + CD4
Vachelová, Jana ; Roithová, Jana (advisor) ; Žabka, Ján (referee)
Title: The growth of larger hydrocarbons in the ionosphere of Titan: C9Hx 2+ + CD4 Author: Jana Vachelová Department: Department of Organic Chemistry Supervizor: Mgr. Jana Roithová, Ph.D. Abstract Dications and multiply charged ions are studied mainly in terms of physical and chemical processes, especially in environments with extremely low temperatures and pressure. Under these conditions the production of higher hydrocarbons is not explained. The aim of this bachelor thesis was a comparison of reactivities of dications derived from three aromatic isomers (indene, methylphenylacetylene and phenylpropadiene) and determination of the dependence of the reactivities on the reaction conditions. The main experimental method was mass spectrometry. It was found that the reactivities of dications generated from indene, methylphenylacetylene and phenylpropadiene are different and depend on the reaction conditions. Key words: dications, electron ionization, mass spectrometry, isomers
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