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National Repository of Grey Literature 2 records found  Search took 0.00 seconds. 
New biomarkers and candidate molecules in antifibrotic therapy in systemic scleroderma
 Štorkánová, Hana ; Tomčík, Michal (advisor) ; Javorková, Eliška (referee)
Systemic scleroderma (SSc) is a systemic connective tissue disease affecting skin and internal organs. The pathogenesis of SSc is characterized by inflammation, vasculopathy and fibrosis. No agent has been proven effective in the treatment of SSc. There is a lack of suitable biomarkers for monitoring the disease activity or the response to the treatment of SSc. Therefore our aim was to analyse the extracellular levels of S100A4, Hsp90 (Heat shock protein 90) and IL-35 (interleukin-35) in SSc. S100A4 and Hsp90 have been initially studied in tumours; in some of them considered as suitable prognostic markers and candidates for future therapies. We have recently described the profibrotic role of S100A4 and Hsp90 in the pathogenesis of SSc. Our results showed that inactivation of S100A4 and Hsp90 effectively prevented the development of experimental skin fibrosis. This was consequently confirmed by the analysis of S100A4 and Hsp90 in the peripheral blood of patients with SSc, where significant associations with disease activity and organ involvement were detected. IL-35 may become another potential biomarker of SSc. We detected increased expression of IL-35 in the affected skin, dermal fibroblasts and in serum of patients with SSc. Moreover, the main profibrotic mediator transforming growth factor...
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Crohn's disease
 Štorkánová, Hana ; Pavlasová, Lenka (advisor) ; Ehler, Edvard (referee)
Crohn's disease The Bachelor study summarizes the present knowledge of inflammatory diseases, which attack the digestive system. The Crohn's disease is classified as idiopathic or nonspecific intestine inflammations, since its cause is still not known. In my thesis I describe the general characteristics of the Crohn's disease, the possible causes, the symptoms of the disease and the subsequent therapy. Key words: Crohn's disease, nonspecific intestine inflammations
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