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Jihlava climbing hall
Příleský, Nikolas ; Šťastný, Marek (referee) ; Sedláková, Markéta (advisor)
The subject of this thesis is the development of project documentation for the construction of the Jihlava climbing hall. The new building is located in Jihlava, cadastral territory of Bedřichov u Jihlavy. It is a free-standing object with one underground and two above-ground floors, located on a slightly sloping plot towards the river Jihlava. The building is structurally divided into two parts, namely a part of the climbing hall with one floor above ground and a part with a shop and a cafe with refreshments. The building with a shop and cafe also serves the needs of the building and athletes. It is designed as a basement with three floors. In the underground floor there are technical rooms and changing rooms for athletes. The main entrance with a shop, reception and rooms for employees is located on the first floor. On the second above-ground floor there is a cafe with refreshments, a bar counter, a room for food preparation and hygiene rooms for visitors. The load-bearing structural system is divided into steel frames placed on reinforced concrete pillars with cladding made of sandwich panels mounted on a grid of thin-walled steel profiles. Aluminum facade plates with variable thickness are attached to the sandwich panels. The part where is a shop with a cafe and athletes' locker rooms is designed as a monolithic reinforced concrete combined skeleton with a cross-reinforced ceiling plate. Between the buildings and on part of the facade, there is infill masonry made of ceramic blocks between the columns, in the part adjacent to the climbing hall, blocks with better acoustic properties are designed. The facade is solved using a contact insulation system made of basalt wool insulation boards. In the room of the cafe and shop, a light outer shell is designed to form the glass corner facade of the building, to improve the climate in these rooms, the glass facade is shielded by the overhang of the roof. The entire building is embedded below the level of the surrounding terrain and is made of waterproof concrete. Single-skin roofs with a classic order of layers with insulation made of softened PVC are designed over the entire building.
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Detached House with Design Office
Šťastný, Marek ; Juračková, Edita (referee) ; Králová, Zuzana (advisor)
The subject of my bachelor’s thesis is drawing a project documentation reguired for construction of a detached house – including a design office. The building will be divided into two parts – a garage and a house itself with a design office in it. The garage is intended for two passenger cars. The building – a detached house – is going to be located in Eastern part of a village Koroužné. The house, including the design office, is going to be constructed as a two – story building. It will be covered with a gabled roof. The garage is designed as a single deck building with a shed roof. Both the buildings will be connected with a porch. There will be a skelter with a gabled roof. Vertical and horizontal structures will be designed from the HELUZ system. The construction would be based on strip foundation.
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System for Remote Monitoring and Management of Garden Pools
Šťastný, Marek ; Jaroš, Jiří (referee) ; Šimek, Václav (advisor)
This thesis deals with the design and subsequent implementation of a wireless system for automatic monitoring and control of a garden pool. In this work, the reader is first introduced to basic water quality measurements. Next, the analysis of wireless technologies and communication protocols is analyzed in this thesis. Based on the knowledge gained, the design and subsequent implementation of the system modules and the web application that controls the system has been carried out. The thesis concludes with a description of how the modules were tested and the functionality of the whole system was verified.
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Apartment House
Šťastný, Marek ; Havířová, Zdeňka (referee) ; Lavický, Miloš (advisor)
The subject of my diploma thesis is elaborating the project documentation for making a new building of a separately standing apartment house. The building is situated on the outskirts of town Bystřice nad Pernštejnem, on a slightly slanting land which goes up to the northeast. The building is without cellar, four-storeyed with a flat roof. On the first floor above ground level there are an indoor garages, cellar units, a staircase and an elevator. On the second, third and fourth floor above ground level there are separate housing units, a staircase and an elevator. There are other parking areas on the exterior of the building. The vertical constructions are designed within the system HELUZ, the horizontal constructions are made of ferroconcrete. The perimeter structures are designed with the contact insulation system. The building will be based on foundations.
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System for Remote Monitoring and Management of Garden Pools
Šťastný, Marek ; Jaroš, Jiří (referee) ; Šimek, Václav (advisor)
This thesis deals with the design and subsequent implementation of a wireless system for automatic monitoring and control of a garden pool. In this work, the reader is first introduced to basic water quality measurements. Next, the analysis of wireless technologies and communication protocols is analyzed in this thesis. Based on the knowledge gained, the design and subsequent implementation of the system modules and the web application that controls the system has been carried out. The thesis concludes with a description of how the modules were tested and the functionality of the whole system was verified.
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The prognostic and predictive role of immune check point inhibitors in ovarian cancer patients
Raková, Jana ; Palich Fučíková, Jitka (advisor) ; Šťastný, Marek (referee)
Epithelial ovarian cancer is the sixth most common tumor disease among women and it is the leading cause of death from all types of gynecologic malignancies. The current standart of care consist of debulking surgery followed by platinum-taxane chemotherapy. Althought some patients benefit from the treatment, most eventually experience platinum-resistance and die from this disease. Immunotherapy based on application of immune checkpoint blockers represents a new treatment strategy in different cancer malignancies. However, emerging clinical data show only limited clinical efficacy of these agents in ovarian cancer patients with objective response rates of 10-15%. Therefore there is a strong need to identify a potential biomarkers, which allows to identify the group of patients, who will benefit the most from this costly treatment. The aim of my diploma thesis was to characterize the prognostic and predictive role of the immune checkpoints within the retrospective and prospective cohort of patients with high-grade serous ovarian cancer (HGSOC). Our study follows, that the expression of PD-L1 molecule and high frequencies of PD-1+ tumor infiltrating lymphocytes (TILs) in tumor microenviroment is significantly correlated with a better prognosis of patients with HGSOC. Moreover, PD-L1 and PD-1...
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Apartment House
Šťastný, Marek ; Havířová, Zdeňka (referee) ; Lavický, Miloš (advisor)
The subject of my diploma thesis is elaborating the project documentation for making a new building of a separately standing apartment house. The building is situated on the outskirts of town Bystřice nad Pernštejnem, on a slightly slanting land which goes up to the northeast. The building is without cellar, four-storeyed with a flat roof. On the first floor above ground level there are an indoor garages, cellar units, a staircase and an elevator. On the second, third and fourth floor above ground level there are separate housing units, a staircase and an elevator. There are other parking areas on the exterior of the building. The vertical constructions are designed within the system HELUZ, the horizontal constructions are made of ferroconcrete. The perimeter structures are designed with the contact insulation system. The building will be based on foundations.
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Detached House with Design Office
Šťastný, Marek ; Juračková, Edita (referee) ; Králová, Zuzana (advisor)
The subject of my bachelor’s thesis is drawing a project documentation reguired for construction of a detached house – including a design office. The building will be divided into two parts – a garage and a house itself with a design office in it. The garage is intended for two passenger cars. The building – a detached house – is going to be located in Eastern part of a village Koroužné. The house, including the design office, is going to be constructed as a two – story building. It will be covered with a gabled roof. The garage is designed as a single deck building with a shed roof. Both the buildings will be connected with a porch. There will be a skelter with a gabled roof. Vertical and horizontal structures will be designed from the HELUZ system. The construction would be based on strip foundation.
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Antracyklinová antibiotika na bázi protilátkou směrovaného HPMA
Říhová, Blanka ; Strohalm, Jiří ; Jelínková-Ibrahimová, Markéta ; Kovář, Marek ; Šubr, Vladimír ; Etrych, Tomáš ; Mrkvan, Tomáš ; Šťastný, Marek ; Plocová, Daniela ; Šírová, Milada ; Hovorka, Ondřej ; Kubáčková, K. ; Ulbrich, Karel
Conjugates based on N-(2-hydroxypropyl)methacrylamide represent a new generation of polymeric anticancer drugs with improved therapeutic potential and considerably decreased nonspecific side effects. Antibody -targeted derivatives show specific active targeting and nonspecific passive accumulation in solid tumors.
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