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Molecular mechanisms of sterile inflammation in damaged hematopoietic tissue
Čiháková, Zuzana ; Faltusová, Kateřina (advisor) ; Bačová, Barbora (referee)
Hematopoietic tissue is home to hematopoietic stem cells (HSCs), which continuously generate all blood and immune cells. Tissue damage or cellular stress can lead to sterile inflammation. In response to the sterile inflammation, HSCs are activated to proliferate and switch to emergency hematopoiesis. Long-term exposure of hematopoietic tissue to inflammatory signals leads to increased differentiation at the expense of self-renewal of HSCs, DNA damage, and genetic instability, which can lead to cell death, permanent bone marrow damage and hematopoietic damage.
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Statistical Analysis of the Unemployment Development in the Central Region and its Expected Tendencies
Čiháková, Zuzana ; Prášilová, Marie (advisor) ; Svobodová, Jitka (referee)
This Bachelor's thesis deals with the statistical analysis of proportion of the unemployed in the Central Region and its districts, the structure of the unemployed by gender, age and education with a focus on risk groups during the period of 2007-2015. Own elaboration includes an analysis of the results in the Central Region and the proportion of the unemployed is observed. Using elementary characteristics of time series and trend function the amount for the year 2016 will be predicted. The last part of thesis contains an evaluation of the results with recommendations of how to reduce unemployment in the region. Data were obtained mainly from the Czech Statistical Office and from Ministry of Labour and Social Affairs.
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