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Role of Pregnancy-associated Proteins and other Biomarkers in Diagnostics and Pediction of Prognosis of Renal Cell Carcinoma
Čechová, Marcela ; Babjuk, Marek (advisor) ; Broďák, Miloš (referee) ; Hartmann, Igor (referee)
Role of Pregnancy-associated Proteins and other Biomarkers in Diagnostics and Prediction of Prognosis of Renal Cell Carcinoma Abstract The work describes the role of pregnancy-associated proteins, pregnancy-associated plasma protein A (PAPP-A) and placental growth factor (PlGF), in relation to renal cell carcinoma (RCC) and their possible use as a biomarkers of this tumour. The theoretical part of the thesis summarizes the essential knowledge of RCC focused on prognostic factors of this malignancy and provides a comprehensive overview of potential biomarkers. In the experimental part serum concentrations of PAPP-A and PlGF in patients operated for clear cell RCC were evaluated and their potential value in diagnostics and prediction of prognosis of subjects with this most frequent histological subtype of RCC was assessed. Furthermore, the thesis evaluates the relation of selected single nucleotide polymorphisms of PAPP-A gene [C/G SNP (rs13290387) a Cys327Cys SNP (rs12375498)] to the most common histological subtypes of RCC (clear cell, papillary I and II type, chromophobe) and oncocytoma. Based on our results, PAPP-A does not seem to be a suitable marker for diagnosis or evaluation of prognosis in patients with ccRCC, however, PlGF appears to be a potential diagnostic and prognostic marker of this disease....
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Identifikace stěžejních faktorů ovlivňujících spotřebitelské chování v cestovním ruchu
Čechová, Marcela
This thesis examines the factors that affect consumer behavior in tourism. The main objective of this work is based on a questionnaire survey to identify these factors, in relation to quality. In primary research will be found out, how consumers behave in tourism today and will be revealed the factors that determine the quality of services. From the analyzed data will be presented recommendations for improving the quality of tourism services.
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Women awareness of breast cancer prevention
Vytlačilová, Monika ; Vachková, Eva (advisor) ; Hodačová, Lenka (referee) ; Cechová, Marcela (referee)
This Backelor Thesis cinsiders women awareness of breast cancer prevention. The theoretical part deals with anatomy and physiology of mammary gland, types of breast cancer and their diagnostics and possibilities of treatment. It is engaged in risk faktors and prevention as well. The empirical part is comprised of quantitative questiannaire method, which finds out women interest of their own prevention, awareness of breast selfexamination, mammography screening and risk faktors. Analysis samle is made up of 87 women at the age of 25 to 69.
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Identifikace stěžejních faktorů ovlivňujících spotřebitelské chování v cestovním ruchu
Čechová, Marcela
This thesis examines the factors that affect consumer behavior in tourism. The main objective of this work is based on a questionnaire survey to identify these factors, in relation to quality. In primary research will be found out, how consumers behave in tourism today and will be revealed the factors that determine the quality of services. From the analyzed data will be presented recommendations for improving the quality of tourism services.
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