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The determination of the end-to-side anastomosis within the neurotization techni ques in thebrachial plexus reconstruction and the influence of the locally appli ed VEGF on the peripheral nerve regeneration
Kaiser, Radek ; Haninec, Pavel (advisor) ; Zvěřina, Eduard (referee) ; Ehler, Edvard (referee)
There is rising importance of the brachial plexus injury firstly due to its increasing incidence as a result of higher survival rate of the patients after polytrauma and due to the higher success rate of the surgical treatment. Recently, the obstetric brachial plexus palsy is the area of interest of many articles. The indication criterion is one of the most important problems to be solved as well as increasing awareness about the possibility of the surgical treatment. Many of injured elements of the brachial plexus are reconstructed by a donor nerve transfered onto the recipient nerve, i.e. by neurotization. This method can have better outcome than the suturing of the proximal parts of the plexus especially due to its main advantage - suturing as close to the muscle as possible. It is still not clear which donor nerve is better to use for neurotization of specific recipients due to the lack of large randomized clinical trials. End-to-side anatomosis (ETS) was re-discovered at the beginning of 90's at the same time when the Oberlin method (OT) was firstly described in the literaure. These techniques are applicable only in the Erb's palsy with functional lower part of the plexus. The basis of the effect of ETS anastomosis is the collateral sprouting of the axons which is one of the most important...
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Neural and Genetic Basis of Epilepsy
Figelová, Tereza ; Ehler, Edvard (advisor) ; Pavlasová, Lenka (referee)
This thesis describes neural and genetic basis of epilepsy, addresses the distribution of epileptic sezuries, which genes affect epilepsy and the connection between epilepsy and the nervous system. The thesis is based on data collection from scientific books, partly from data published by hospitals. Its focus is getting from the general expressions to the cellular level of the problem, which is necessary to clarify the epileptic principles. It also deals with the genetic nature of epilepsy, as it is with the inheritance of the disease and deals in more detail with early infantile epileptic. The beginning of work is about basic information of epilepsy. Next, it looks into the mechanisms that influence the emergence of epilepsy. Continues to look at the structures in the brain associated with epilepsy. And at the end, it deels with genetic nature of epilepsy. A brochure was created for this work, where basic information about epilepsy can be found, first aid for an epileptic seizure and early infantile epileptic encephalopathy is discussed in paragraphs.
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Y-chromosomal polymorphisms in the Czech population with focus on Moravian Valachs: evolutionary anthropology study.
Ehler, Edvard
Aim: This study presents an evolutionary anthropology approach to the history of Moravian Valachs. The origins of Valach population are approached by evaluating the admixture event that marked the appearance of Moravian Valachs. Methods & data: Focus of my Ph.D. project lies on Y-chromosomal variation, using 12 Y-STR loci haplotype to compute population genetic statistics, to infer Y-chromosomal haplogroup information and to compare Moravian Valachs to other European populations. Admixture analysis was performed. Our data set contains haplotypic information from 44 populations with the total of 4757 individuals. Moravian Valachs are presented by 94 DNA samples. Results: Our data reveal a decreased genetic variability in Moravian Valachs compared to other Central European populations. This feature is most probably caused by isolation of Valach population. Multidimensional scaling and comparison of FST distances shows Valach population as related to populations from Poland, Romania and Macedonia. Shared haplotypes and AMOVA tests place the Valachs to the Central European region. Also admixture analysis, as well as demographic and historical data, stresses the influence of autochthonous population of Moravia in the forming of Moravian Valachs. Conclusion: Moravian Valachs represent a hybrid...
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Left-handedness and its acceptance in contemporary education system and families
Svobodová, Libuše ; Vančata, Václav (advisor) ; Ehler, Edvard (referee)
TITLE: Left-handedness and its acceptance in contemporary education system and families AUTHOR: Libuše Svobodová DEPARTMENT: Department of Biology and Environmental Studies SUPERVISOR: doc. RNDr. Václav Vančata, CSc. ABSTRACT: The diploma thesis entitled Left-handedness and its acceptance in contemporary education system and families follows up and complements the bachelor thesis entitled The issue of left- handedness in the development of children and youth - history, present and perspectives. The first and second chapters of the theoretical part of the diploma thesis focus more deeply on the characteristics of left-handed writing styles, advantages and disadvantages of left-handed writing, suitable writing aids, classroom order, organization of work environment and writing methodology. The third chapter is devoted to laterality tests with a focus on the upper limb, lower limb, eye and ear, test tasks, their conditions and evaluation. The last fourth chapter of the theoretical part deals with the central nervous system, more precisely the brain and its asymmetric anatomy, function, control of upper limb movements and motor development of the upper limb. The practical part of the diploma thesis consists of five researches. The first research verifies the occurrence of left-handers in primary schools and...
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