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Inhabitants of Hlučínsko-region in the Czechoslowak foreign army in the West
Neminář, Jiří ; Čechurová, Jana (advisor) ; Plachý, Jiří (referee)
The thesis deals with the almost unknown theme - the soldiers from the district of Hlucin serving in the Czechoslovakian foreign legions in the West. Using the example of the inhabitants of the Hlucin area, it shows the conditions under which the former Wermacht soldiers' recruitment to the Czechoslovakian army had taken place. It tries to give a true picture of the specifics of the participants from the district of Hlucin in the foreign revolt and to outline the possible motivation for the decision to enter the foreign legions, the way the soldiers presented themselves in front of the interrogating officers as well as different views of their evaluation from the Czechoslovakian officers' perspective. The goal of the thesis is to show the almost unknown reality of their military service besides Wehrmacht and to bring the total number and ranks of the soldiers from the district of Hlucin within the Czechoslovakian troops to light. Both the quantitative analysis based on the list of the individual soldiers and several qualitative analyses dealing mostly with military draft and interrogation documents helped to reach the goal. Besides, the fonds of various military institutions and the local Hlucin authorities were also taken into account.
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Variability of the domestic chicken breeds in selected immunological traits of hen and egg
Bílková, Barbora ; Vinkler, Michal (advisor) ; Plachý, Jiří (referee) ; Trefil, Pavel (referee)
The avian immune system is a complex system of defence mechanisms that protect bird hosts against threats from ubiquitous pathogens. According to the co-evolutionary models, variability in immune traits of hosts is the key component providing ability to adapt and enhance their defence mechanisms in presence of constant selective pathogen pressure. Domestic chicken (Gallus gallus f. domestica) is used as a model organism in avian biology and also is one of the most important food-producing animals, not only for their meat but also for the egg production. Unfortunately, in research usually only inbred chicken lines are used and modern poultry husbandry is tight with unilateral breeding towards highly productive breeds. Those approaches decrease intra-population polymorphism in chickens. However, especially in case of farm animals, searching and extending the pool of immune variability and enhancing pathogen resistance is crucial for sustaining healthy and biologically secure populations and their products. Morphologically highly distinct traditional chicken breeds, which have evolved for hundreds years under different selective pressures, may represent this desirable immunological variability. In my thesis I described variability in chosen immunological traits, haematological parameters and proteomic...
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Data measurement system
Plachý, Jiří ; Bednárek, David (advisor)
The thesis deals with design and implementation of an automated system for measuring, storing and analyzing data gathered from external hardware. At first, various architectures of data measurement systems are compared, their advantages and typical areas of application are described. Next, different types of measuring probes hardware and data analysis software solutions are compared. Various technologies usable in data measurement system implementation are discussed (in particular A/D converters, connecting the converter to the computer, comparing the software architectures and used technologies). Based on this discussion, technologies for implementation are chosen. The described implementation consists of two-channel probe equipped with 10-bit A/D converter and sample input modules for temperature and voltage. The probe is connected to the USB using the FTDI converter. Practically tested schematics for the probe hardware are included. The implemented software can be used in two configurations - base configuration for easy installation on one computer, hierarchical configuration for complex solutions running on several computers. The text of the thesis, executable files, the user documentation, documented source codes, and documentation of used electronic components can be found on the enclosed CD.
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Variability of the domestic chicken breeds in selected immunological traits of hen and egg
Bílková, Barbora ; Vinkler, Michal (advisor) ; Plachý, Jiří (referee) ; Trefil, Pavel (referee)
The avian immune system is a complex system of defence mechanisms that protect bird hosts against threats from ubiquitous pathogens. According to the co-evolutionary models, variability in immune traits of hosts is the key component providing ability to adapt and enhance their defence mechanisms in presence of constant selective pathogen pressure. Domestic chicken (Gallus gallus f. domestica) is used as a model organism in avian biology and also is one of the most important food-producing animals, not only for their meat but also for the egg production. Unfortunately, in research usually only inbred chicken lines are used and modern poultry husbandry is tight with unilateral breeding towards highly productive breeds. Those approaches decrease intra-population polymorphism in chickens. However, especially in case of farm animals, searching and extending the pool of immune variability and enhancing pathogen resistance is crucial for sustaining healthy and biologically secure populations and their products. Morphologically highly distinct traditional chicken breeds, which have evolved for hundreds years under different selective pressures, may represent this desirable immunological variability. In my thesis I described variability in chosen immunological traits, haematological parameters and proteomic...
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FEM analysis of carriage for top drive system of drilling rig and its modification
Plachý, Jiří ; Čížek, Petr (referee) ; Klapka, Milan (advisor)
This diploma thesis deals with FEM analysis and optimization of carriage for top drive system of drilling rig Bentec 350 AC and it is defined as a development contract for company MND Drilling & Services a.s. Intensive drilling leads to damages and repeated occurrence of fatigue cracks on carriage especially along edges of welded ribs in their heat-affected zone. The aim of this thesis is to draft construction improvements of carriage which leads to elimination of damages. Realization of this modifications depends on correct definition of boundary conditions, analysis of damage occurrence as well as verification of carriage drafts with finite element method.
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Loss of Sub-Carpathian Ruthenia at the End of World War 2
Hubený, David ; Rychlík, Jan (advisor) ; Plachý, Jiří (referee) ; Němeček, Jan (referee)
Loss of Sub-Carpathian Ruthenia at the End of World War 2 David Hubený Czechoslovakia came by Sub-Carpathian Ruthenia completely unexpectedly after World War 1. The Republic tried with dedication to help the Slavonic population of the region, hardly aware of their nationality, get rid of poverty and ignorance. Sub-Carpathian Ruthenia, however, did not fit into the concept of Czechoslovak statehood. Some Czechoslovak politicians (e.g. Karel Kramář) only perceived the mission of the Republic at Sub-Carpathian Ruthenia as the role of a "faithful trustee" that should hand Sub-Carpathian Ruthenia over to Russia when the right time comes. On the other hand, Czechoslovak Communists called the region Trans-Carpathian Ukraine as early as 1920s and alleged that the local Slavonic population are Ukrainians. The Republic did not want to get involved in the ethnic development. At the time of the "Second Republic", power in Sub-Carpathian Ruthenia was seized by Ukrainian Nationalists, who colluded with Nazis. The former saw Sub-Carpathian Ruthenia as kind of Ukrainian Piemont, which would unite all Ukrainians in one state, while the latter found it a perfect tool to destabilize the USSR by opening up the hot Ukrainian issue. Relations of Czechoslovak security services to Ukrainian Nationalists were really bad. Ukrainian...
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Dolní Vilémovice 1939-1945. A Czech Village under the Protectorate of Bohemia and Moravia
Hanák, Zdeněk ; Vojtěchovský, Ondřej (advisor) ; Plachý, Jiří (referee)
Dolní Vilémovice 1939-1945. A Czech Village under the Protectorate of Bohemia and Moravia The thesis deals with the destiny of Dolní Vilémovice, small village which lies in West Bohemia, during the Nazi occupation. It uses sources of local authorities and oral history to describe everyday life of Czech villagers throughout the Second World War. The village mentioned above was not chosen incidentally, as it is a birthplace of Jan Kubiš, one of czech soldiers who commited assassination attempt on Reinhard Heydrich. That is why this thesis also discusses the issue of German repressive measures against the local population, especially against Kubiš family, and anti-Nazi resistance.
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Epigenetic mechanisms in the regulation of antigen presentation and anti-tumour immunity.
Vlková, Veronika ; Reiniš, Milan (advisor) ; Plachý, Jiří (referee) ; Němečková, Šárka (referee)
Veronika Vlková: Epigenetic mechanisms in the regulation of antigen presentation and anti-tumour immunity. Charles University in Prague, Faculty of Science, Molecular and Cellular Biology, Genetics and Virology Dissertation, 2014 Reversible downregulation of MHC class I expression on tumour cells, a common mechanism by which tumour cells can escape from specific immune responses, is frequently associated with coordinated silencing of antigen-presenting machinery genes. The expression of these genes can be restored by IFN-γ. Here we describe association of DNA demethylation of selected antigen-presenting machinery gene regulatory regions upon IFN-γ treatment with MHC class I upregulation on tumour cells thus demonstrating that IFN-γ acts as an epigenetic modifier. Our results cast more light on the role of DNA methylation in tumour cell escape from specific immunity. Treatment of MHC class I deficient tumour by epigenetic modifiers sensitized neoplasia to the immunotherapy. Our data also provide knowledge about differentiation cancer chemotherapies, especially for use in combination with other drugs to achieve lower immunosuppressive function of tumour microenvironment. In addition, our data provide evidence that besides the known targets of epigenetic agents or immunoregulatory antibodies other...
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Robotka's case
Skořepová, Michaela ; Čechurová, Jana (advisor) ; Plachý, Jiří (referee)
(in English): This thesis deals with post-war fate of Josef Robotka the member of the second and third resistence and people who cooperated with him. It cannot be mentioned his activities during the Second World War in the Council of three but the key issue will be the engagement after 1945. I would describe his disenchantment with communist ideas while on Vorošilov military academy in Moscow, subsequently forced to return to Czechoslovakia and post-February intelligence cooperation with CIC. I will also try to bring the role of public authorities in the arrest, detention and trial. In the next section I would like to map the entire arrest of Robotka group, their imprisonment and trial. The following chapters will deal with Robotka's execution and the role of wives and close relatives of convicted persons. The work is based mainly on archival research, supplemented by memories of Vlasta Nováčková Jakubová who is Robotka's niece and close collaborator. Main question is how big the importance of the information that the group sent abroad was and what significance should they have in case of possible conflict.
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