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Analysis of spontaneous adverse events reports of hypolipidemics
Škabradová, Anežka ; Malá, Kateřina (advisor) ; Doseděl, Martin (referee)
Analysis of spontaneous adverse events reports of hypolipidemics Author: Anežka Škabradová Supervisor: PharmDr. Kateřina Malá, Ph.D. Consultant: PharmDr. Josef Malý, Ph.D. Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Introduction: Hypolipidemic drugs are widely used in today's medicine and their consumption is still rising. Besides all benefits, their usage includes also some risks that needs to be reconsidered regularly. Analysis of spontaneous adverse effects (AEs) reports contributes to a safer therapy by detecting especially serious and unexpected adverse drug reactions. Objective: The aim of this thesis was to analyse spontaneous adverse events reports of hypolipidemic drugs, which were sent to the State Institute for Drug Control (SÚKL) database in the period from June 2004 to October 2017. Methods: The data obtained from SÚKL during the above mentioned period was analysed using descriptive statistics. The frequency of occurrence of certain AEs, which were categorized according to MedDRA and distinguished by hypolipidemics, was analysed, as well as their severity and expectability. Part of the analysis was for example also by whom was the report submitted and which way they used to submit it. Results: Overall 290 reports were obtained,...
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Selected aspects of the racionality of use of diuretics in ambulatory care seniors in the EUROAGEISM H2020 project
Gruberová, Natálie ; Fialová, Daniela (advisor) ; Malá, Kateřina (referee)
INTRODUCTION: In the world population, the number of seniors with very heterogeneous health care is increasing. Because of the aging of the organism they are much more sensitive to adverse effects of drugs, therefore geriatric care is more visitors and safety pharmacotherapy. It thus seeks to prevent risky medicines available in geriatric patients. Many explicit targets have been disclosed that can be reserved for the potentially endangered by the elderly. Diuretics are among the classes of drugs that are often prescribed in the geriatric population but which pose significant risks to the geriatric patient. Problems with their unpleasant effects, but also poor indication or combination with minimal drugs. OBJECTIVE: The main aim of this thesis was to describe the frequency and rationality of prescribing diuretics in seniors treated in geriatric outpatient clinics. The use of diuretics in appropriate and potentially inappropriate indications, the occurrence of changes accompanying adverse reactions (including laboratory changes in electrolytes and metabolic parameters) and whether these problems are controlled were monitored. The risks of hyponatraemia associated with diuretic therapy and the use of SIADH-inducing drugs were also assessed in more detail. METHODICS: This thesis was based on the...
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Attitudes and beliefs on HPV infection and vaccination III
Říhová, Andrea ; Zimčíková, Eva (advisor) ; Malá, Kateřina (referee)
Attitudes and beliefs on HPV infection and vaccination III Author: Andrea Říhová Consultant: PharmDr. Eva Zimčíková, Ph.D. Introduction Nearly 80% of world's population will get human papillomavirus (HPV) infection at some point of their lives. More than 99% cases of cervical cancer, which belongs to the second most common malignancy of women, is associated with HPV infection. The most reliable protection against this infection is vaccination. Aims The aim of the work was to find out knowledge of high school students about human papillomavirus and diseases caused by these viruses. In addition, find out the vaccine coverage rate against HPV and attitudes of students to this vaccination. Methods Data for this diploma thesis were obtained by survey, which took place at two high schools in the Usti Region in 2018. Overall, 291 questionnaires were used. Respondents were in age of 15-19. Data were processed by computer program Microsoft Excel. The t-test and Pearson's chi-squared test were used to statistically evaluate the data. Results Average age of the respondents was 17 years and 73.5% of respondents were women. Non- believers (93.5%) and non-smokers (92.4%) predominated among the respondents. Only one of the students did not know the concept of cervical cancer or penile cancer. More than half of...
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Drug Information Centre service analysis III.
Harazimová, Tereza ; Malá, Kateřina (advisor) ; Matoulková, Petra (referee)
Drug Information Centre service analysis III. Author: Tereza Harazimová Supervisor: PharmDr. Kateřina Malá, Ph.D. Consultant: PharmDr. Petra Rozsívalová Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University, Czech Republic Introduction: Drug Information Center (DIC) of the Faculty of Pharmacy in Hradec Králové, Charles University, and University Hospital Hradec Králové was established in 1994. Major activity of the DIC is providing expert information about drugs - primarily in the form of answers to various medicines-related enquiries sent by healthcare professionals. DIC deals with enquiries related to general pharmacotherapy including complementary and alternative medicine (CAM). Aim of study: Aim of the study was to evaluate DIC's activity in the period 2015-2017 through feedback from questioners and to analyse enquiries related to CAM in the period 1994-2017. Methods: The feedback of questioners whosent the enquiry to DIC from 2015 to 2017 was obtained using an online questionnaire containing 18 items - sociodemographic data and awareness of DIC, quality of answers to enquiries, satisfaction with provided services and lastly resolving of CAM related issues in practice. Furthermore, analysis of DIC's database in the period 1994-2017 was performed....
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Possibilities of prothetic treatment for skiers with exarticulation of the knee especially for cross-country skiing
Malá, Kateřina ; Hruša, Jan (advisor) ; Gnad, Tomáš (referee)
Thesis title: Possibilities of prothetic treatment for skiers with exarticulation of the knee especially for cross-country skiing Main objectives: I tried to find out the prosthetic possibilities for the people who have the exarticulation in the knee joint and compare the differences between healthy and amputated person. Goals: 1. Try to find out the possibilities for the cross country skiing to people who are having an exarticulation in the knee joint. 2. Watch the cross-country skier with the exarticulation in the knee joint during the activity and find out the differences with healthy person. 3. Devise a solution how to eliminated the shortcomings and try to minimaze these differences. Methods: This thesis is one case study. I used qualitative research methods to write this thesis. I was collecting data to get more information during observation of my experimetee doing recreational sports activities. Then I compared this information with knowledge obtained in the professional literature about cross-country skiing, healthy and amputated cross-country skiers. Results: In this thesis I found out that there is an available prothesis in the Czech Republic which allows the people with exarticulation in the knee joint to cross-country skiing. However there are any limitations in movement that a healthy...
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Attitudes towards treatment and knowledge of hormonal contraceptives among final year pharmacy students
Pavlíková, Veronika ; Malá, Kateřina (advisor) ; Pokladníková, Jitka (referee)
The attitudes toward the treatment and knowledge about hormonal contraception among the final year pharmacy students Author: Veronika Pavlíková¹ Supervisor: PharmDr. Kateřina Ládová, Ph.D.¹ Consultant: PharmDr. Anna Oleárová, Ph.D., MPHš ¹Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University, Czech Republic šDepartment of Organisation and Management of Pharmacy, Faculty of Pharmacy, Comenius University in Bratislava, Slovak Republic Introduction: Hormonal contraception (HC) is ranked among the widespread birth control methods used in a broad age structure of women worldwide. Based on of the health status, lifestyle, user's preferences or non-contraceptive benefits, it is possible to choose from the wide spectrum of HC, which differs in dosage and composition. Aim: The aim of this thesis was to determine the attitudes toward the treatment and knowledge about the HC among the final-year pharmacy students upon the completion of the mandatory 6-month long practical training in the pharmacy and knowledge acquired during the studies. Methods: The on-line survey was the realized in students of faculties of pharmacy in the Czech Republic and in the Slovak Republic, who had already completed the mandatory 6-month long practical training or who have just been...
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Evaluation of clinical pharmacists interventions in the hospital
Veličková, Zuzana ; Doseděl, Martin (advisor) ; Malá, Kateřina (referee)
EVALUATION OF CLINICAL PHARMACIST'S INTERVENTIONS IN THE HOSPITAL Author: Zuzana Veličková Supervisor of the thesis: PharmDr. Martin Doseděl, Ph.D. Charles University, Faculty of Pharmacy in Hradec Králové, Department of Social and Clinical Pharmacy BACKGROUND The Drug-Related Problem is an event or circumstance involving drug therapy that actually or potentially interferes with desired health outcomes.i Pharmaceutical care deals with management of DRPs and its goal is to decrease occurrence of DRP. AIMS The aim of the study was to describe and evaluate the most common DRPs occurring in the selected department in the hospital. DRPs have been detected during reviews of pharmacotherapy by the clinical pharmacist. METHODS The study was carried out in the hospital in Šumperk, at the department of the internal medicine, the nursing section. Data was collected from medical records of hospitalized patients. Patient's characteristics (age, gender), diagnosis, using drugs, selected laboratory markers and drug- related problems were recorded. DRPs have been identified during reviews of the clinical pharmacist. Description and evaluation of DRPs contain its management, acceptation of pharmacist's intervention, evaluation of clinical severity and cost benefit of intervention. The classification of DRPs was...
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Drug Information Centre service analysis II.
Čikovská, Natália ; Malá, Kateřina (advisor) ; Matoulková, Petra (referee)
Drug Information Centre service analysis II. Author: Natália Čikovská Supervisor: PharmDr. Kateřina Malá, Ph.D. Consultant: PharmDr. Petra Thomson Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University, Czech Republic Introduction: Drug Information Centre (DIC) of the Faculty of Pharmacy in Hradec Kralové was established in 1994 and is the only university-based DIC in the Czech Republic. DIC is providing expert information about drugs, such as answering medicines-related enquiries received from healthcare professionals. Objective: The objective of diploma thesis was to gather and analyze information about the informational service of LIC FAF UK a FN HK in 1994-2016 aimed for general characteristics of drug enquiries and professional drug information resources used for solving the enquiries. Methods: Detailed analysis of DIC activities was performed to compile suitable data. All enquiries from years between 1994 and 2016 were summarized into a database using Microsoft Excel software. General characteristics of the enquiries were analyzed, such an average number of enquiries per year or time needed for resolving one enquiry. Information about enquirers was considered as well, e.g. their profession and region, from which the enquiries were sent....
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Possibilities of prothetic treatment for skiers with exarticulation of the knee especially for cross-country skiing
Malá, Kateřina ; Hruša, Jan (advisor) ; Gnad, Tomáš (referee)
Thesis title: Possibilities of prothetic treatment for skiers with exarticulation of the knee especially for cross-country skiing Main objectives: We try to find out the prosthetic possibilities for the people who have the exarticulation in the knee joint and compare the differences between healthy and amputated person. Goals: 1. Watch the cross-country skier with the exarticulation in the knee joint during the activity and find out the differences with healthy person. 2. Devise a solution how to eliminated the shortcomings and try to minimaze these differences. Methods: This thesis is empirical-theoretical nature. The methods which we used are comparative analysis and observation with the following description. The observed variables were our thesis proband in comparison with our own expirience about cross-coutry skiing. Results: In our thesis we find out that there is an available prothesis in the Czech Republic which allows the people with exarticulation in the knee joint to cross-country skiing. However there are any limitations in movement that a healthy people do not have. Key words: femoral amputation, the prothesis, C-leg, cross-country skiing with a prothesis, cross-country skiing after amputation
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Mortality in high ages
Malá, Kateřina ; Mazurová, Lucie (advisor) ; Cipra, Tomáš (referee)
In this thesis, we study modelling of mortality in high ages by several approaches. Some of mentioned models take into account the phenomenon of mortality deceleration. Further, we present several ways of estimating of exposed to risk in (almost) extinct cohorts. We focus especially on the survivor ratio method but we also mention the MD method and the DG method. Finally, we perform a numerical study.
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