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není uveden
Soukup, Viktor ; Babjuk, Marek (advisor) ; Mareš, Jaroslav (referee) ; Novák, Jaroslav (referee)
Immunohistochemical examination of microvascular density can be an additional prognostic factor in patients with superficial urinary bladder carcinoma, nevertheless, more extensive studies need to be carried out. Maximal microvascular density correlated with a recurrence free interval and in a case of bigger group of patients could be statistically significant. The statistical correlation between MVD and a nuclear p53 accumulation is that significant that we assume the p53 importance in the angiogenesis regulation of superficial urinary bladder carcinoma. The p53 positivity in non-tumor mucosa of urinary bladder in patients with superficial bladder cancer correlates with higher risk of tumor recurrence. According to our results the reason of urinary bladder carcinoma multifocality is genetic instability present in the whole urothelium at the time of tumor diagnosis. The PAX5 gene expression is a frequent finding in superficial transitional cell carcinoma of the bladder. From the prognostic point of view, high levels of PAX5 expression seem to be connected with higher recurrence and progression rates. The extent of lamina propria invasion seems to be a clinically relevant prognostic factor for progression of T1 bladder transitional cell carcinoma. Finding T1b tumor is connected with the risk of understaging....
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Cardiorespiratory fitness of sporting population
Novák, Jaroslav ; Zeman, Václav (advisor) ; Votík, Jaromír (referee) ; Heller, Jan (referee)
Cardiorespiratory kapacity in sporting population J. Novák Summary VO2max and VO2max/kg values were directly obtained during 2777 measurements in competitive athletes and active but not competing subjects. The normatives of cardiorespiratory capacity for different age groups of male and female endurance athletes (Group A), team sport players (Group B) and other sports (group C) were established, and compared to normatives for Czech population based on the International Biological Program (IBP) results (Seliger a Bartůněk 1976). The most favorable values of cardiorespiratory capacity (both VO2max; VO2max/kg and W170;W170/kg) were found in the group A athletes (endurance trained) - both males and females. Their level highly exceeded the values of untrained CS IBP population and also those obtained in control group D in this study. The highest correlation was found between VO2max and Wmax and between VO2max/kg and Wmax/kg. This high correlation was very similarly high in the whole sample of 2777 examinations, in the sample of men (n=2015) and women (n=762) and also in all age-groups in different athletic groups A to D. It was proved that VO2max and VO2max/kg values could be calculated according to the maximal performance attained on bicycle ergometer. During spiroergometric examination the values of stroke...
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Problems of renal tumours in patiens with terminal stadium of renal failure
Ürge, Tomáš ; Hora, Milan (advisor) ; Novák, Jaroslav (referee) ; Zachoval, Roman (referee) ; Morávek, Petr (referee)
Objective: Risk of renal carcinoma is minimal 10 x higher in group of patients in terminal stadium of renal failure (end stage kidney disease - ESKD). We have only some information about chromosomal changes in renal tubules, from which rise renal carcinoma, and about pathogenesis of renal carcinoma, which seems to be different from carcinoma in common population. Aim of the study: In clinical part we valorize characteristic signs of renal carcinoma in ESKD by using of statistic methods. In experimental part we can explain pathogenesis of this carcinoma by analysis of selective chromosomal aberations. Material, methods: In 2000 - 2007 were 184 patients with ESKD in care of transplant centre and nephrologic ambulation of Faculty hospital Plze_. In 15 patients we diagnose renal carcinoma. In this group we valorize: age, gender, causation of renal failure and dialysis duration. Age, gender and type of renal carcinoma we confront with carcinoma in common population. In experimental part we valorize numerical aberations in chromosome 7, 17 and Y of tubular epithelium using fluorescent hybridization in situ (FISH). Results: We have 15 patients in average age 55.7 ± 11.5 years, long of during dialyzation was 78 ± 54 months. We do not find dependence between causation of renal failure and genesis of renal...
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Prevention of postural defects in the population
Langmajerová, Jana ; Müllerová, Dana (advisor) ; Novák, Jaroslav (referee) ; Dlouhý, Pavel (referee)
This dissertation aims at verifying methodology used for somatographic evaluation of the shape and statics of the spine. The potential of the methodology verified lies in increased objectivity of upright body posture evaluation and thereby contributes to the specification of preventative measures for postural defects, and their consequences. Under a cross-sectional pilot study, a non-invasive somatographic method-a diagnostic DPT-3 system designated for spine shape diagnostics-was used to examine selected biomechanical parameters (spinal curves and statics in the sagittal plane in the upright position) in a total of 508 probands. Of this, 326 were school-age children and 182 adults. Among the key parameters monitored were: Cl (depth of cervical lordosis); LI (depth of lumbar lordosis); the sagittal balance of Cl/Ll, and VThk (distance of the peak of the thoracic kyphosis from the ideal verticals-IV). A questionnaire was used to evaluate the level of movement activity in probands and the relation between the occurrence of painful back and headaches and the measurement of biomechanical parameters and movement activity. A total of 81.3 % of children and 94.5 % of adults were found to have deviations from the biomechanically ideal posture model, which signals a postural defect. The values of the Cl (p...
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Gamification and its use in online education
Potoček, Marek ; Vaňková, Petra (advisor) ; Novák, Jaroslav (referee)
This bachelor thesis focuses on the term gamification and its use in online education. In the theoretical part the thesis defines the terms "gamificiation", games" and "online education" and briefly describes the basic principles, history and usage. In the practical part, the thesis focuses on mapping out the most important websites, portals and then it selects appropriate applications that can support today's online education.
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