|
|
Acyclic Nucleoside Phosphonates as Inhibitors of Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferase: New Anti-Malarial Chemotherapy Leads
Hocková, Dana ; Holý, Antonín ; Česnek, Michal ; Baszczyňski, Ondřej ; Tichý, Tomáš ; Krečmerová, Marcela ; Janeba, Zlatko ; Skinner-Adams, T. S. ; Naesens, L. ; Keough, D. T. ; de Jersey, J. ; Guddat, L. W.
Hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRTase) is a widely recognized target for the discovery of new anti-malarial drugs. Specific acyclic nucleoside phosphonates (ANPs) inhibit HGXPRTase and possess anti-plasmodial activity. Within the framework of a SAR-study, the classical ANPs (e.g. PME-, PMP- and HPMP-derivatives) as well as novel series of compounds were tested to investigate their efficiency and selectivity on the inhibition of P. falciparum, P. vivax and human enzyme.
|
|
| |
|
| |
|
| |
|
|
Multiprocessor Randomized On-line Scheduling
Tichý, Tomáš
This paper studies randomized on-line non-preemptive scheduling in multiprocessor systems. In this problem each task is specified by its processing time andscheduled on any of $m$ identical processors. The objective is to minimize theexpected mekespan. We prove lemmas and theorems describing $sigma_m$-competitive randomized algorithms on $m$ processors. The main result is an........
|
|
|
Online competitive algorithms for maximizing weighzed throughput of unit jobs. ITI Series 2003-172
Bartal, Y. ; Chin, F. Y. L. ; Chrobak, M. ; Fung, S. P. Y. ; Jawor, W. ; Lavi, R. ; Sgall, Jiří ; Tichý, Tomáš
We study an online buffer management problem for networks supporting Quality-of-Service (QoS) applications, equivalently as an online scheduling problem forunit-length jobs, where each job is specified by its release time, deadline, and a nonnegative weight (QoS value). The goal is to maximize the emph{weighted throughput}, that is the total weight of scheduled jobs.
|
|
| |
|
| |
|
| |
|
| |
host ::
RSS.