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Basal stimulation
Novotná, Lenka ; Schneiderová, Michaela (advisor) ; Kupečková, Ivana (referee) ; Juřeníková, Petra (referee)
The paper deals with the sence of a basal stimulation. It's composed of a theoretical part and a practical one. In the theoretical part there is global information about basal stimulation, its components and development. The paper is directed on positioning and the main accent is on the nest position. The influence on psychical and physical perception is included too. Explored group is composed of healthy persons and patients who are suffering from stroke and are hospitalizated on the Neurological clinic. In the practical part there is research that in praxis explores how do people react in the nest position. All of them expressed their feelings by drawing a picture with comentary.
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Mechanisms coordinating auxin metabolism and transport
Novotná, Lenka ; Petrášek, Jan (advisor) ; Serre, Nelson Bernard Calixte (referee)
Auxin is a small molecule that functions as a plant hormone, and it exists in several forms, of which indole-3-acetic acid (IAA) is the most studied one. IAA modulates cell elongation, division, and differentiation by generating local gradients, and it is essential for almost every aspect of plant growth and development. These gradients are established by the cooperation of IAA biosynthesis, metabolism, and transport. A plant responds to both local auxin maxima and minima; thus, it is necessary to regulate auxin metabolism and transport tightly. However, lots of studies show the roles and regulation of auxin metabolism and transport separately, providing quite rarely discussion on the cooperation of these two processes. Hence, this thesis aims to sum up and refer to mechanisms and regulation of auxin metabolism and transport as a whole, rather than separately, and underline the importance of the cooperation of both auxin metabolism and transport in the plant development.
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Study of human pepsin phosphorylation
Novotná, Lenka
Novotná L.: Abstract of Ph.D. Thesis Protein phosphorylation is one of the most important post-translational modifications in nature. The process of protein phosphorylation/dephosphorylation regulates almost all cellular processes and plays a key role in the maintaining of cell homeostasis. Abnormal phosphoryla- tion is associated with many serious human diseases including cancers. The phosphorylation of main gastric aspartic proteases pepsins and their precursors varies among animal species. Pepsins and pepsinogens of several species contain phosphate groups, while others have no phosphate groups. Phosphorylation of human pepsins and pepsinogens is probably associated with different gastric diseases. Gastric cancer patients show higher phos- phorylation degree of pepsinogens compared to healthy subjects. To utilize this finding for diagnostic purposes, it is requisite to elaborate simple and reliable methods for the study of pepsin and pepsinogen phosphorylation, which could be applied to limited sample amounts. This thesis focuses on the elaboration of appropriate methodical approach for the study of protein phosphorylation, particularly phosphorylation of human pepsins, which are characte- rized by a very low content of basic amino acid residues and a higher content of acidic amino acid residues. The...
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Tailoring of phase composition and microstructure of calcium phosphate scaffolds applied in regenerative medicine.
Pejchalová, Lucie ; Novotná, Lenka (referee) ; Salamon, David (advisor)
Vápenaté fosforečnany jsou nejčastěji využívané keramické materiály v medicíně pro regeneraci kostní tkáně. Vápenaté fosforečnany jsou biokompatibilní, bioaktivní a mezi sebou se odlišují především rozpustností a související degradací v organismu, proto jsou nejčastěji využívány k regeneraci malých defektů nebo jako vrstvy na kovových implantátech. U již zmíněné rozpustnosti materiálu po implantaci, hraje důležitou roli poměr zastoupení jednotlivých vápenatých fosforečnanů, od kterého se pak odvíjí rychlost degradace materiálu v organismu. Tato práce se zabývá vlivem tvarovacích metod na mikrostrukturu a zejména fázové složení vápenatých fosforečnanů. Výchozím materiálem pro pozorování změn ve fázovém složení byl komerční hydroxyapatit, který byl upraven kalcinací při 800 °C po dobu jedné hodiny. Při kalcinaci došlo k vytvoření dvoufázové směsi, obsahující hydroxyapatit a -fosforečnan vápenatý. Tato dvoufázová směs byla poté využita pro přípravu suspenze s plněním 15 obj.%, a také k přímé přípravě polotovarů s různou výslednou mikrostrukturou a fázovým složením. S cílem zjistit vliv procesu byly v této práci porovnány vzorky připravené pomocí metod: freeze-casting, izostatické lisování za studena, uniaxiální lisování a suspenzní odlévání. U polotovarů a slinutých vzorků byla provedena charakterizace mikrostruktury a analýza fázového složení. V práci se potvrdil vliv tvarovací metody na oba stanovené parametry – mikrostrukturu a fázové složení. Nově pak bylo zjištěno, že se zvyšující se hodnotou porozity a velikostí pórů se zvyšuje i zastoupení hydroxyapatitu ve vzorcích. Tento trend byl pozorován u vzorků vykazujících unimodální i bimodální zastoupení velikosti pórů.
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Impact of macro channels on mechanical stability of bone scaffolds during indirect 3D printing
Vojníková, Michaela ; Novotná, Lenka (referee) ; Salamon, David (advisor)
Porous materials are currently subject to the great interest of tissue engineering. They provide unique properties such as bioactivity, biodegradability, osteoconductivity, and vascularization. Particularly, ceramic porous systems show appreciable potential in medical applications. However, there is a crucial problem with the porous scaffold on account of their bad mechanic properties and therefore they are presently used only at low-load locations. This thesis focuses on the preparation of the scaffolds made of hydroxyapatite by using the freeze-casting method where the indirect 3D printing was applied to get open channels with the size over 200 µm. It also compares the mechanical properties of the scaffolds with different internal structures and monitors how the implementation of different types of grids affects the resulting stability. The scaffolds were prepared with a different arrangement of macro-channel in the internal structure, but they had equal dimensions as common property. The 3D grid was implemented before freezing into the mold and afterward the grid was eliminated by sintering, leaving only a channel system with the size 540-600 µm in the final scaffold. The influence of the type of the 3D grid on the resulting mechanical stability of the scaffold was determined. Rotation of this grid does not have a significant effect on the result, while it only helps with cracking in the direction of the helix. The combination of these methods reports very good controllability with directed macro-channels in the resulting scaffold and therefore it is suitable for the preparation of the bone-implants with different structures.
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Tailoring of cooling procedure during freeze-casting for bone replacement applications.
Šantavý, Tomáš ; Novotná, Lenka (referee) ; Salamon, David (advisor)
Bachelor thesis focuses on preparation of hydroxyapatite ceramics by freeze-casting. Hydroxyapatite is an important ceramic material, due to its biocompatibility, biodegradability and bioactivity it has a wide range of use in medicinal applications especially in replacement of bone material. The chosen method, freeze-casting, is flexible, eco-friendly and we are able to achieve a high level of porosity. The method includes freezing, freeze drying and sintering which creates a porous structure of the prepared material. Objective of this bachelor thesis was to find out the impact on the created porosity and mechanical properties of the final material. Freezing rates were applied 3, 4, 5, 6, 7 and 26 m/s. During the experimental part it was established that the freezing rate has a significant influence on the newly formed inner microstructure, it directly influences the interlamellar distances and mechanical property which is compressive strength. With liquid nitrogen with a speed of 26 m/s the achieved compressive strength was of 15 MPa as well as the shortest interlamellar distances of 14-22 µm. With slower freezing rate the average interlamellar distances were 40-150 µm and compressive strength of 2-4 MPa with comparable porosity.
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Impact of the company's allocation to optimize its operation using the principles of facility management
Novotná, Lenka ; Fellow, Ondřej Štrup, IFMA (referee) ; Hromádka, Vít (referee) ; Somorová,, Viera (referee) ; Tichá, Alena (advisor)
A number of partial restructuring measures are offered to optimize business operation to improve its efficiency and performance. The structure inside the company is one of the most important tools for managing its performance and its correct definition, and a proper and meaningful distribution can play a key role in the competitive environment. In many cases, the requirement for optimization of operation will arise from the requirements of facility management, and therefore restructuring measures relating to organizational changes should be implemented with respect to the principles of facility management or should be based on its optimization. This thesis presents the impact of restructuring measures by centralizing of divisions on optimizing its operation with respect to the facility management. The aim of the dissertation is to evaluate the organizational change in the company with several divisions, taking into account the principles of facility management. The result of this thesis are the methodical recommendations during the establishment and evaluation of the division´s centralization in the company. It is based on the findings from the literature review and the real change in the building company.
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Leisure Time Activities of Mentally Challenged and Disabled Adults
KRONIKOVÁ NOVOTNÁ, Lenka
Possible leisure time activities for handicapped and multihandicapped adults Experiencing leisure time is an integral part of modern human being, including handicapped person. Therefore, it´s important to spend it as meaningfully as possible. My bachelor thesis focuses on possible leisure time activities for handicapped and multihandicapped adults compared to such activities in healthy individuals. The main goal was to identify free time activities of persons with disabilities. The thesis is divided in to two parts a theoretical one and practical one. A theoretical one is concerned with basic characteristics of characteristics of health, mental and combined disability. Terminology, etiology and classification for each type are described. Furthermore, a definition of leisure time, its types and possible activities are elaborated on. The end of a theoretical part explains potential problems with experiencing leisure time for handicapped persons. A practical part takes a larger portion of my thesis. Qualitative research approach was chosen to gather data using semi-structured interviews. These were analyzed via clustering method. Two groups were interviewed, the main one consisting of 10 handicapped persons and a control one with 10 people without disabilities. Most interviewed took place in Home of sv. Anežka in Týn nad Vltavou, Sheltered housing Duha in Písek, which fall under control of Home for disabled people Zběšičky. Few additional interviews took place in Písek and Týn nad Vltavou.
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Communication Mix of the Company
Novotná, Lenka ; MBA, Petr Bilavčík, (referee) ; Kaňovská, Lucie (advisor)
Diploma thesis deals with communication mix of company Zahradní centrum V Aleji. The theoretical part of the thesis defines the basic concepts from marketing, marketing mix and communication mix. The analytical part of the thesis describes the current situation of the company, analysis macro environment and micro environment, marketing research and SWOT analysis. At the end of the thesis are presented suggestions which should lead to improvement of the communication mix.
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Cost Analysis of the family houses
Novotná, Lenka ; Aigel, Petr (referee) ; Výskala, Miloslav (advisor)
This thesis has been written for the purpose of acquiring results which would help a builder with choosing material and construction method with respect to price. The thesis deals with comparison of construction costs when utilizing contemporary materials and using various possibilities of construction itself.
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