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CAMM of vasopressin analogs
Huml, Karel ; Barth, Tomislav
Vasopressin and its nonapeptide analogs were studied using computer aided molecular modeling (CAMM) methods to elucidate their structure-bioactivity relationships. The results are discussed in relation to experimentally obtained data of these peptides concerning their biological activities.
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Qualitative and quantitative microanalysis and preparative purification of biopeptides by capillary and continuous free-flow electrophoresis
Kašička, Václav ; Prusík, Zdeněk ; Sázelová, Petra ; Ježek, Jan ; Jiráček, Jiří ; Hlaváček, Jan ; Velek, Jiří ; Barth, Tomislav
High-performance capillary electrophoresis (HPCE) has been applied to qualitative and quantitative analysis of several biologically active peptides and their derivatives and fragments, e.g. insulins, insect oostatic hormones, and peptide and glycopeptide dendrimers.
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Semisynthetic preparation of human insulin analogs containing .I.N./I.-methylated B.sup.24./sup.-B.sup.25./sup. or B.sup.25./sup.-B.sup.26./sup. peptide bonds
Klasová, L. ; Huml, Karel ; Barthová, J. ; Ubik, Karel ; Kašička, Václav ; Škarda, Josef ; Hauzerová, Linda ; Barth, Tomislav ; Wollmer, A. ; Brandenburg, D. ; Ježek, Jan ; Velek, Jiří
Desoctapeptideinsulin (DOI), prepared by tryptic cleavage of porcine insulin, was utilized in the enzyme-catalyzed synthesis of human insulin analogs modified in the C-terminal region of the B-chain.
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