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The influence of deep brain stimulation on the brain connectivity
Horváthová, Ľubica ; Výtvarová, Eva (referee) ; Klimeš, Petr (advisor)
Hĺbková mozgová stimulácia (DBS) predstavuje účinnú liečbu pre pacientov s Parkinsonovou chorobou (PD) alebo farmakorezistentnou epilepsiou. Avšak mechanizmy, ktorými znižuje počet záchvatov a zlepšuje pohyb, zostávajú ešte do značnej miery neznáme. Pre lepšie pochopenie a určenie, v ktorých frekvenčných pásmach je zmena najdôležitejšia, boli urobené porovnania medzi vypnutou a zapnutou DBS pomocou korelačnej metódy a indexu fázového posunu. Jedenásť pacientov s PD a naimplantovanými neurostimulátormi z firiem Medtronic a St.Jude Medical bolo predmetom nahraných dát použitých v tejto práci. Výsledky dokazujú, že zmena konektivity počas DBS nastane a zároveň, že najviac ovplyvňuje najvyššie frekvencie ako beta, nízka gama a vysoká gama. Zmeny v týchto frekvenciách, zodpovedné za motorickú aktivitu, sústredenie a spracovanie informácií, sú v súlade s klinickou teóriou o PD. Počas tejto choroby je patologická beta aktivita hypersynchronizovaná a gama aktivita je znížená práve v motorických oblastiach. Ak sa gama aktivita počas zapnutej stimulácie zvyšuje, fyziologický stav pacientov sa čiastočne znovuobnovuje a tým zlepšuje ich hybnosť. Metódy a výsledky tejto práce budú použité pre ďalší výskum pacientov s PD a epilepsiou.
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Specific behaviour of soldiers towards reproductives of termite genus Prorhinotermes (Isoptera: Rhinotermitidae).
Dolejšová, Klára ; Šobotník, Jan (advisor) ; Klimeš, Petr (referee)
Soldier caste is the oldest altruistic caste in termites, highly specialized for defensive tasks. Therefore, a number of adaptations in anatomy and behaviour can be observed in soldier, lacking in other termite castes. The aim of this study was to verify the hypothesis that in disturbed groups the soldiers will prefer to stand by and defend the reproductives, the most valuable individuals. Therefore, I studied in two species of the genus Prorhinotermes (P. simplex and P. canalifrons) the ability of soldiers to discriminate neotenic reproductives and provide them with defence. In agreement with the initial hypothesis, the soldiers of both species prooved to be able of an instantaneous recognition of reproductives and remained close to them. In P. simplex, the neotenic female was the most attractive individual, while in P. canalifrons, neotenics of both sexes were equally attractive. The observed preference of reproductives appears to occur only with a certain age of the reproductives in incipient colonies, along with their sexual maturation. Caste specificity of cuticular lipids supports the presumption that the caste recognition is based on olphactoric cues in the cuticle of reproductives.
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Establishing Mutual Links among Brain Structures
Klimeš, Petr ; Hlinka,, Jaroslav (referee) ; Krajča,, Vladimír (referee) ; Halámek, Josef (advisor)
The Human brain consists of mutually connected neuronal populations that build anatomically and functionally separated structures. To understand human brain activity and connectivity, it is crucial to describe how these structures are connected and how information is spread. Commonly used methods often work with data from scalp EEG, with a limited number of contacts, and are incapable of observing dynamic changes during cognitive processes or different behavioural states. In addition, connectivity studies almost never analyse pathological parts of the brain, which can have a crucial impact on pathology research and treatment. The aim of this work is connectivity analysis and its evolution in time during cognitive tasks using data from intracranial EEG. Physiological processes in cognitive stimulation and the local connectivity of pathology in the epileptic brain during wake and sleep were analysed. The results provide new insight into human brain physiology research. This was achieved by an innovative approach which combines connectivity methods with EEG spectral power calculation. The second part of this work focuses on seizure onset zone (SOZ) connectivity in the epileptic brain. The results describe the functional isolation of the SOZ from the surrounding tissue, which may contribute to clinical research and epilepsy treatment.
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HTML5 Graphics based Ticket Reservation System
Klimeš, Petr ; Šeda, Miloš (referee) ; Poliščuk, Radek (advisor)
The purpose of the thesis is to design and implement on-line reservation system, which will graphically display an interactive map of the reservation place and will enable to create and redesign these places. The system is going to serve as reservation and sale tool for tickets on cultural, social and other events.
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Reconstruction and strengthening of reinforced concrete ceiling construction
Klimeš, Petr ; Zich, Miloš (referee) ; Perla, Jan (advisor)
The final thesis deals with strengthening of cast-in-place concrete ceiling in existing construction for couple of escalators. New prestressed beam, columns in new positions and strengthened girder with unbonded strands are building in this adjustments. Every member, including the existing construction, is verified for ultimate and serviceability limit state. Prestressed members are alternatively designed with bonded strands and these variants are comparison in terms of utilization and calculation.
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Double Layer Porous Asphalt with Aspahlt-rubber Binder
Klimeš, Petr ; Hegr, Zdeněk (referee) ; Kudrna, Jan (advisor)
The possibilities of double layer porous asphalt usage and rules for design of porous asphalt mixtures are introduced in this work. The porous asphalt mixtures PA 8, PA 11 and PA 16 are designed with different content of asphalt-rubber according to Marshall Test method. The water sensitivity, drainability, particle loss of these PA are determined. The permanent deformation and drainability of double layer PA 8 and PA 11 were also determined. The possibility of usage of this double layer porous asphalt with expected decreasing of traffic noise was proved.
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Model of traffic lights crossroads
Klimeš, Petr ; Zuth, Daniel (referee) ; Marada, Tomáš (advisor)
The purpose of this bachelor work is concept and realisation of traffic lights crossroad model which is controlled by programmable logic controller (PCL). Model is supposed to be used as a laboratory device during practical lessons of programmable logic controllers to demonstrate basic principle of semaphore lights controlled traffic crossroad.
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