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National Repository of Grey Literature

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	Mechanismus působení polymerních léčiv na bázi HPMA Hovorka, Ondřej ; Strohalm, Jiří ; Bouček, Jan ; Etrych, Tomáš ; Šubr, Vladimír ; Ulbrich, Karel ; Říhová, Blanka However cytostatic polymeric conjugates based on N-(2-hydroxypropyl)methacrylamide are in clinical trials, we are still far away from understanding the mechanism of their action. Cleavability of the drug from oligopeptidic side-chains of polymeric carriers seems not to be necessary condition for pharmacological activity and those spacers play most probably a very important role in the accumulation of conjugates in tumor cells. Detailed record
	Protinádorová směrovaná léčba na bázi HPMA: základní principy pro syntézu konjugátů a převod z laboratoře do kliniky Říhová, Blanka ; Strohalm, Jiří ; Prausová, J. ; Kubáčková, K. ; Jelínková, Markéta ; Rozprimová, L. ; Šírová, Milada ; Plocová, Daniela ; Etrych, Tomáš ; Šubr, Vladimír ; Mrkvan, Tomáš ; Kovář, Marek ; Ulbrich, Karel Conjugates of N-(2-hydroxypropyl)methacrylamide with doxorubicin containing human IVIg were used for palliative treatment in patients with advanced cancer. More thena 116 biochemical and immunological parameters were tested. A decrease of some parameters with patological values was seen, and physiological values were occasionally reached, including some TAA. Detailed record
	Polymerní protirakovinná léčiva s pH- a enzymaticky závislou aktivací Etrych, Tomáš ; Chytil, Petr ; Strohalm, Jiří ; Jelínková, Markéta ; Kovář, Marek ; Říhová, Blanka ; Ulbrich, Karel Water-soluble synthetic polymers and their conjugates with antibodies, oligopeptides or saccharides proved a potential targetable drug delivery system. Recently, copolymers of N-(2-hydroxypropyl)methacrylamide (HPMA) have been developed in our laboratory as polymeric carriers of drugs. Detailed record

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