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Bone metabolism, infection and ischemia in diabetic foot syndrome
Bém, Robert ; Jirkovská, Alexandra (advisor) ; Štěpán, Jan (referee) ; Broulík, Petr (referee)
The diabetic foot (DF) is one of the most frequent late complications of diabetes, which often leads to limb amputation and effects the quality of life in patients with diabetes. Ischaemia and infection play important role in pathogenesis of DF. One form of DF is Charcot neuroosteoarthropathy (CNO), defined as a noninfectious destruction of bones and joints in the foot due to diabetic neuropathy. The subject of the dissertation thesis was divided into 3 parts: bone metabolism and CNO, ischaemia and infection in DF and new methods in the treatment of DF. (...) In the third study, new quantitative scintigraphic parameters for assessment of CNO activity were defined and confirmed their satisfactory correlation with other parameters of CNO activity. In fourth and fifth study,good reproducibility was verified and efficiency of power spectral analysis of heart rate variability as a new method for diagnosis of autonomic neuropathy in patients with CNO. Sixth study refered to rare causes of atypical localization of CNO in the knee joint. Ischaemia and infection in DF were resolved in one study. In multivariate analysis of seventh study we approved, that risk factors for difficulty healing after minor amputation of the foot were low level of transcutaneous oxygen tension and high level of C-reactive protein before...
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Vascular Calcification and Bone Demineralization in Patiens with Chronic Renal Failure
Mareš, Jan ; Opatrná, Sylvie (advisor) ; Topolčan, Ondřej (referee) ; Spustová, Viera (referee) ; Štěpán, Jan (referee)
Background: Patients treated with chronic dialysis show extreme mortality, particularly due to cardiovascular disease. Renal failure is associated with different risk factors of cardiovascular complications than those defined for non-renal population. One of these factors, currently considered most important, are vascular calcifications. At the same time, patients on dialysis regularly suffer from derrangements of calcium-phosphate metabolism, including skeletal demineralization. As a consequence, both incidence and prevalence of bone fractures are high. Aims: This study therefore investigates vascular calcifications and skeletal demineralization, their clinical implications and associations in patients treated with long-term dialysis. Methods: Two groups of patients were examined in a prospective manner (follow-up > 1 year); 32 patients treated with peritoneal dialysis and 72 treated with regular hemdodialysis. Treatment parameters and biochemical markers of calcium-phosphate metabolism were monitored throughout the study. Bone mineral density of lumbar spine (together with vertebral fractures) as well as coronary artery, valvular and aortic calcifcations were determined repeatedly. All radiological parameters were measured during one computed-tomography scanning session. Results: A significant...
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Nursing process in ill with chronic pulmonary obstructive disease (COPD)
Baráková, Eva ; Tomová, Šárka (advisor) ; Štěpán, Jan (referee)
The topic of my bachelor project is the nursing process in patient with chronic obstructive pulmonary disease (COPD). My patient is female, 68 years oldo I describe the anatomy, physiology of the lungs, etiology, patophysiology, epidemiology, symptoms, prognosis and prevention of COPD. I nursed the patient in accordance with the Majora Gordonova's model. Powered by TCPDF (www.tcpdf.org)
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Design of Optimization of Track Section Bylnice - Vlárský Průsmyk
Štěpán, Jan ; Mráz, Martin (referee) ; Plášek, Otto (advisor)
The focus of the thesis is to design a optimization of the geometrical layout of the track for an increase of the track speed to the highest possible value and a reconstruction of the permanent way superstructure between railway stations Bylnice - Vlárský Průsmyk. The work also includes a design of sleeper subsoil, renewal of the drainage and a design of the construction technology and procedures. Necessary view triangles will be added for unsecured level crossings.
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Design of Modernization of Bohuslavice nad Vláří Railway Station
Štěpán, Jan ; Pur, Kamil (referee) ; Plášek, Otto (advisor)
The focus of the thesis is to design a modernization of the Bohuslavice nad Vláří train station. The reconstruction design includes an adjustment of the station head and the geometrical layout of the track for an increase of the track speed to the highest possible value. The design also contains a renewal of the railway superstructure and the structure of the sleeper subsoil, new drainage and platforms. The designed layout ensures a safe access for people with reduced mobility.
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Speed of the internet in Czech Republic
Štěpán, Jan ; Pavlíček, Antonín (advisor) ; Samcová, Ivana (referee)
This thesis will discuss the development of the Internet. The first part of the thesis will describe the development of the Internet both world wide and in the Czech Republic. The following part will analyse the quality of the high-speed Internet and its coverage accord-ing to government legislation concerning high-speed Internet. This legislation is a part of the plan "Europe 2020". The following part will describe the method used for measuring of the Internet speed and analyse the current statistics data of the Internet speed. Those data will be analysed to find out good and bad sides of the statistics. Some other interesting facts will be presented in the thesis. The following chapter will answer the question why those figures are important and what kind of influence those figures have for regular users. The last part will present my own measurements of the Internet speed in Czech Republic. The thesis will also answer the question about how users of Internet in Czech Republic perceive the real speed of the Internet and its coverage in all regions.
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MS Dynamics AX 2012 and its conception of Business Intelligence extension in comparison with MS Power BI tools
Štěpán, Jan ; Stanovská, Iva (advisor) ; šprungl, Petr (referee)
The main goal of the bachelor thesis entitled "MS Dynamics AX 2012 and its conception of Business Intelligence extension in comparison with Power BI tools" is to analyze available BI tools for creating reports and analytical outputs in ERP solution Microsoft Dynamics AX 2012. Another goal of the thesis is to compare these tools with other Microsoft Business Intelligence tools including PowerPivot, Power View, Power Map and Power Query which are free of charge and they are part of MS Office Excel 2013 package as well. The final evaluation of these tools is based on amount of available functions, and its advantages and disadvantages and all benefits for end users. The beginning of this thesis is focused on the current situation of ERP systems with BI modules and applications on the Czech market. The analysis of available solutions is divided into the groups according to the size of the companies - small, midsize and large companies. Some of these solutions are described in detail. The main part of the thesis is focused on the ERP system Microsoft Dynamics AX 2012 and its BI tools possibilities in comparison with BI tools which are available in MS Excel 2013.
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Strategy of an Enterprise
Králová, Pavla ; Kovář, František (advisor) ; Štěpán, Jan (referee)
The subject of the diploma thesis is the processing of a future development strategy of a concrete company based on its strategy analysis. The thesis is divided on two main parts, where the first describes theoretical and methodological bases, whose findings are then used in the second, practical part. To achieve the company's future strategy is used to approach of the strategic planning cycle. In its analytical part is analyzed the external and internal environment of the company by which are proposed options for the future development of the company in a strategic part, based on acceptance criteria. Finally, in the implementation of the strategic planning cycle are long-term strategic objectives of the selected company decomposed to short-term goals, providing the operational management.
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Optimalizace cílové tloušťky při nepasečném způsobu hospodaření na ŠLP ML Křtiny
Štěpán, Jan
This thesis deals with the optimization of the target thickness in the forest managed under systems involving coupes, when converting to a permanent forest (not managed under systems involving coupes) on ŠLP ML Křtiny. The optimization was focused on Scots pine, European beech, Oak sessile and Norway spruce tree species. The final optimal target thickness was established as the intersection of biometric and economic aspects for pine 45 cm (range 39-52 cm), for beech 50 cm (range 44-56 cm) and for spruce 52 cm (range 48-58 cm). In the case of oak in the natural conditions, the culmination of the thickness growth is not occurred. That could reach dimensions of trees, they need, in addition to the appropriate site conditions ensure appropriate production measures the optimal cenotic position, respectively a growth area. The average social area is for oak 26.22 m2, for pine 29.08 m2, for beech 25.26 m2 and for spruce 22.88 m2. The average available crown space is for oak 27.83 m2, for pine 26.59 m2, for beech 23.64 m2 and for spruce 19.38 m2. The average available stem space is around 74 m2 for oak, 84 m2 for pine, 71 m2 for beech and 66 m2 for spruce. Since it is an exact determination of the culmination of the thickness growth using growth ring analysis is time consuming, is better a simpler (operational) the landscaping solutions in adult stands, trip during which evaluates production potential habitats and species on the basis of the achievements of the individual dimensions of the strongest individuals in a selected population. This information is suitable ideally complement the statistical data from the operational inventory, and it must modify their best as the upper quartile breast height diameter of the wood.
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