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Synthesis of Substituted Phthalocyanines with Bulky Substutients
Zajícová, Ivana ; Zimčík, Petr (advisor) ; Nováková, Veronika (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of pharmaceutical chemistry and drug control Candidate Mgr. Ivana Zajícová Consultant Doc. PharmDr. Petr Zimčík Ph.D Title of Thesis Synthesis of substituted phthalocyanines with bulky substutients Synthesis of symmetric phthalocyanines and naphthalocyanines containing bulky substituent (tert- butylsulfanyl and later pentan-3-ylsulfanyl group) in their structure was aim of my master thesis. The precursors, 6,7-bis(tert-butylsulfanyl)naphthalene-2,3-dicarbonitrile and two 3,6-disubstituted phthalonitriles were prepared as starting materials. Synthesis of 3,4,12,13,21,22,30,31-octakis(tert- butylsulfanyl)naphthalocyaninato zinc(II) complex proceeded without any problems using diazabicycloundecene and zinc acetate in butanol. However, cyclotetramerization of precursor to octakis- 1,4,8,11,15,18,22,25-(tert-butylsulfanyl)phthalocyaninato zinc(II) complex was problematic. I could not find a suitable method of synthesis. As an alternative to this compound I tried to prepare analogue containing flexible pentane-3-ylsulfanyl instead of tert-butylsulfanyl group. In this case, a magnesium butoxide was used as initiator of cyclotetramerization. Magnesium complex was transformed to the zinc complex by removal of central magnesium...
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Synthesis of ceramide analogues based on 5C sphingosine
Drozen, Tomáš ; Vávrová, Kateřina (advisor) ; Nováková, Veronika (referee)
Charles University in Prague, Faculty of Pharmacy in Hradci Králové Department of anorganic and organic chemistry Candidate: Tomáš Drozen Supervisor: Doc. PharmDr. Kateřina Vávrová, Ph.D. Title of Diploma thesis: Synthesis of ceramide analogues based on 5C sphingosine Ceramides are lipids, in particular sphingolipids. They have many important roles in the organism. Ceramides form the main part of lipid matrix in the stratum corneum, the uppermost skin layer, and take an important part in maintaining skin barrier properties. Membranes of eukaryotic cells also contain ceramides, and both ceramides and their derivatives formed in organism are important signalling molecules. They act as both primary and secondary messengers, participating in regulation of cell growth, apoptosis and inflammatory responses. Although ceramides have been investigated for a long time, there are still many unanswered questions. Fo rthe understanding of the ceramide functions, it is necessary to investigate their movement in the organism and study the effects of their analogs with changed structure. Olefin metathesis is often used for synthesis of analogs with varying chain length or different florescent labels. This thesis describes attempts to synthesise ceramide analogs with very short sphingosine chain, which can be used...
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Synthesis and Study of Properties of Aza-analogues of Phthalocyanines
Nováková, Veronika ; Zimčík, Petr (advisor) ; Kuča, Kamil (referee) ; Kubát, Pavel (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Department of Pharmaceutical Chemistry and Drug Control Candidate Mgr. Veronika Nováková Supervisor doc. PharmDr. Petr Zimčík, Ph.D. Title of Doctoral Thesis Synthesis and study of properties of aza-analogues of phthalocyanines Phthalocyanines (Pc) and their azaanalogues azaphthalocyanines (Azapc) are planar macrocyclic compounds with significant absorption band at 620-720 nm finding application in the areas such as photodynamic therapy, chemical catalysis and solar cells. Photophysical (fluorescence) and photochemical (singlet oxygen production) parameters are important in above mentioned applications. Peripheral substituents of Pc/AzaPc play key role in this case. Alkylsulfanyl and alkyloxy derivatives exerted high fluorescence quantum yields (ΦF) as well as quantum yields of singlet oxygen (ΦΔ). On the other hand, alkylamino substitution led to almost zero values of both ΦF and Φ∆. These derivatives have recently found new application as dark quenchers in DNA hybridization probes. The first part of this thesis demonstrated that intramolecular charge transfer (ICT) is responsible for zero values of quantum yields of alkylamino AzaPc and that the lone electron pair of peripheral nitrogen is a donor for ICT in AzaPc....
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Azaphthalocyanines substituted with one aminogroup - influence of aliphatic substituents on intramolecular charge transfer.
Zajícová, Ivana ; Zimčík, Petr (advisor) ; Nováková, Veronika (referee)
CHARLES UNIVERSITY IN PRAGUE FACULTY OF PHARMACY IN HRADEC KRALOVÉ DEPARTMENT OF PHARMACEUTICAL CHEMISTRY AND DRUG CONTROL Name: Ivana Zajícová Supervisor: Doc. PharmDr. Petr Zimčík Ph.D Azaphthalocyanines substituted with one aminogroup-influence of aliphatic substituents on intramolecular charge transfer. At the beginning of my thesis I was working on synthesis of 1,2,6,7,11,12,16,17- octakis-[(4-dimethylamino)benzylidenamino] porphyrazine from N,N-bis[(4- dimethylamino)benzylidenamino]fumaronitrile and N,N-bis[(4-dimethylamino) benzylidenamino]maleonitrile. Cyclotetramerization was performed with magnesium butoxide, zinc acetate in quinoline or in N, N-dimethylformamide. Unfortunately, no product was obtained. As an alternative aim, I started to deal with synthesis of unsymmetrical azaphthalocyanines substituted with one amino group. The amino group is a donor in intramolecular charge transfer. This process competes with fluorescence and singlet oxygen formation and may lead to compounds useful as dark quenchers of fluorescence in hybridization probes. I prepared a precursors, substituted pyrazine-2,3-dicarbonitriles, containing primary amino group, diethylamino- or butylamino- group. Prepared precursors were cyclotetramerized by method of statistical condensation. Cyclotetramerization was carried out in...
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Organizational culture in healthcare organization: a case study
Nováková, Veronika ; Mudd, Dana (advisor) ; Trunda, Jiří (referee)
The topic of the thesis is "Organizational culture in healthcare organization: a case study". In the theoretical part of the thesis basic definitions, terms and aspects associated with organizational culture are introduced. Further the thesis deals with diagnostic issues of organizational culture and presents specific factors related to the organizational culture in medical facilities. The empirical part deals with diagnose of organizational culture in the Czech hospital, using modified instrument for measuring organizational OCAI, based on the Competing Values Framework developed by R. E. Quinn and J. Rohrbaugh.
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Organizational culture and its impact on organizational efficiency
Nováková, Veronika ; Trunda, Jiří (referee) ; Mudd, Dana (advisor)
The topic of the bachelor thesis is "Organizational culture and its impact on organizational efficiency". In the theoretical part of the thesis basic definitions, terms and aspects associated with organizational culture are introduced. Further the thesis deals with relationships between organizational culture and organizational membersand presents specific factors related to the organizational culture in medical facilities .. Thethesis also focuses on diagnostic issues of organizational culture. Findings prezented in the theoretical part are used as basis in the empirical part. The empirical part deals with the relationship between organizational values in a hospital and tendency of employee turnover (nurses). Key
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Optimization of production process
Nováková, Veronika ; Krásová, Anna (referee) ; Fiala, Alois (advisor)
The aims of this dissertation are to analyze the current state of process control, to identify the product range in selected organization and to design the process planning methodology to ensure an optimal implementation. Optimization is understood as costs minimization while keeping an acceptable continuity of supply. The dissertation contains a description of technological and non-manufacturing processes of brick products, as well as the summary and description of the basic tools of quality management.
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Proposal and Valuation of Investment Project
Nováková, Veronika ; Kocourková, Gabriela (referee) ; Vítková, Eva (advisor)
The Master thesis contents a propsal and evaluation of an investment project. The master thesis is divided into a theoretical and a practical part. The theoretical part describes the investment project together with an investment plan. The investment plan is further developed in more details and deals with a market analysis, a marketing plan, a size and a location of a company, its human resources, an operating plan, a financial plan, a financial analysis and above all with methods of assessment of investment projects. The practical part focues on a specific investment project proposal and its subsequent evaluation. The proposal offers a marketing research with a financial plan and financial analysis. The assessment of the project is carried out by using different methods of assessment of investment projects.
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Marketing Research of Customer Satisfaction
Nováková, Veronika ; Kramolišová, Eva (referee) ; Šimberová, Iveta (advisor)
The thesis deals with a survey of customer´s satisfaction in the company KABESTAV. The theoretic part describes the problematics of marketing research and a questionnaire as a tool for collecting information. The practical part is describing company; where, in which way and with what results was the costumer satisfaction survey made. These indicators are shown in tables and graphs. Further the thesis continues by final evaluation of the costumer satisfaction survey and finishes by improvement proposals chapter.
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