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Synthesis of human ω-O-acylceramides and evaluation of their effects on barrier properties of skin lipid membranes
Opálka, Lukáš ; Vávrová, Kateřina (advisor) ; Hampl, František (referee) ; Kučerka, Norbert (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Inorganic and Organic chemistry Candidate: Mgr. Lukáš Opálka Supervisor: doc. PharmDr. Kateřina Vávrová, Ph.D. Title of doctoral thesis: Synthesis of human ω-O-acylceramides and evaluation of their effects on barrier properties of skin lipid membranes The main objective of this work was to synthesize and study human acylceramides (acylCer, ceramides of the EO type) with the focus on the relationships between the acylCer concentration , structure of their polar head, their ability to form lamellar phases and permeability of model lipid membranes. Another objective was to synthesize ceramide-1-phosphates for the study of their signaling role in skin barrier and an analogue of ganglioside GM1 with shorter acyl chain as a standard for analysis of these lipids. Ceramides (Cer) belong to the family of sphingolipids. They are the central molecules in sphingolipid metabolism, they participate on cell regulatory processes and the formation of human skin lipid barrier. The main skin barrier is situated in the stratum corneum (SC), which is the uppermost layer of skin. The purpose of SC is to maintain homeostasis of the inner environment and to prevent the penetration of exogenous substances, allergens and bacteria to the...
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Synthesis and study of ceramide analogues
Školová, Barbora ; Vávrová, Kateřina (advisor) ; Matějka, Pavel (referee) ; Šklubalová, Zdeňka (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of inorganic and organic chemistry Candidate: Mgr. Barbora Školová Supervisor: doc. PharmDr. Kateřina Vávrová, Ph.D. Title of doctoral thesis: Synthesis and study of ceramide analogues Ceramides (Cer) together with free fatty acids and cholesterol form intercellular lamellar space of the uppermost skin layer (stratum corneum, SC). This lipid matrix presents the proper skin barrier - it protects organism against outer environment and keeps its homeostasis as well. The composition and arrangement of the intercellular lipid matrix is essential for the skin barrier properties. In spite of this fact, the organization of SC lipids at the molecular level is not fully elucidated. The aim of this work is to contribute to more detailed insight into organization of skin barrier using SC lipid model membranes, in particular to find the structural parameters in ceramide molecules, which play a role in the maintenance of the skin barrier. The SC model membranes present a useful tool to study SC lipids, they mimic physiological or pathological conditions in the skin. The obtained results should be used in diagnosing or therapy of skin diseases characteristic with impaired barrier function, such as atopic dermatitis or psoriasis....
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Land Analysis needful for complex landscaping
Vávrová, Kateřina ; Kottová, Blanka (advisor) ; Klára, Klára (referee)
This thesis deals with a detailed analysis of available data for the area, which is the cadastral area Malý Bor district Klatovy, which subsequently serves as a major
base for the actual process of implementing the komplex landscaping. It also includes my own field research.
In the first part are described in detail and explained the particular concepts related to the landscape, landscaping, and for them the important materials. In another part is defined the researched area and it is described in terms
of historical, typological, geomorphological, geological, climatic, hydrological, phytogeographical and geobiocenological.
In the following part there is the description of the available materials and economic land use. With all these available data have been maked particular analyzes that lead to evaluation road infrastructure, water and wind erosion, the situation of nature and landscape protection, water management measures and landscape greenery. Everything is completed by findings from the field research
and my own photographs. On these findings are based and individual recommendations or warnings, which serve as comments in a case of implementation of comprehensive landscaping.
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The issue of inclusion of hearing-disabled people
VÁVROVÁ, Kateřina
This bachelor thesis called "The issue of inclusion of people with hearing disabilities" speaks about people with hearing difficulties, more specifically their integration into mainstream society. The dissertation is divided into theoretical part which acquaints us with hearing impairment as such. The bachelor thesis is addressing the classification of hearing impairment, dealing with assistive technology for hearing impaired persons, communication systems of hearing impaired persons, and finally mentions the issue of inclusion and integration of hearing impaired persons. The practical part describes the research methodology, the research objectives and goals, it includes a (public) survey and its processing and includes the interview with Michal Brhel who is also deaf. The aim of this bachelor thesis is to find out how the ongoing integration of handicapped people into mainstream society is being done and point out its main issues and difficulties. Especially the difficulty in employment area.
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Music Education in Czech republic
Vávrová, Kateřina ; PIVODA, Radomír (advisor) ; VÁLEK, Jiří (referee)
Master thesis "musical arts education in the Czech Republic" is about music education in the Czech Republic from primary, secondary to tertiary education. It affects the admission procedure, course of study, chamber music, concerts, competitions, theoretical courses, degree courses, orchestral and concert practice, the use of students, future employment and bringing their own opinion on the study of the Czech and German schools. It compares the number of schools with Germany and Austria, reflects the overall situation in the education and application in practice. Compares way of teaching at the music school, conservatory and university in the Czech Republic and Germany.
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Flute interpreting courses and their contribution to student Academy of performing arts in Prague.
Vávrová, Kateřina ; Pivoda, Radomír (advisor) ; Válek, Jiří (referee)
Thesis "Flute interpreting courses and their contribution for a student Academy of Performing Arts in Prague" deals about flute courses in the Czech Republic and abroad, and as the name suggests, primarily a benefit for the student. Here we find the names of courses, date, short biographies of the professors, the course, student benefits, pros and cons of the organizational management of AD. The conclusion is a summary of courses and a comparison with the Academy of Performing Arts in Prague. Work lightly touching each course, the goal is not detailed analysis. The information collected allows the reader to peek into five different classes and read up on the short characteristics, personalities, concerts, lessons, and in particular on the impact and benefits for the student.
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Business and Cultural Specialities of Senegal
Vávrová, Kateřina ; Müllerová, Františka (advisor) ; Korandová, Jiřina (referee)
This thesis provides complex information about Senegal with regard to its relations with the Czech Republic. The first chapter presents basic information about the territory, such as geography, demography and history of Senegal and detailed characterisctics of local population. The second chapter discusses the current political and economic situation in the country as well as its foreign-policy orienation. The third chapter describes the position of Senegal in international trade and focuses on its relations with the Czech Republic. The last chapter is an overview of Senegalese society and culture, with an emphasis on cultural aspects of business negotiation in the country.
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Dangerous substances in electrical apparatus
VÁVROVÁ, Kateřina
The diploma thesis deals with the influence of dangerous substances in electric aparatus on environment and also on human. The aim of this diploma thesis is to describe toxicological characteristics of dangerous substances in electric apparaus and to find out people´s awareness about electro apparatus hazardousness and electric waste by mean of questionnaires. The thesis first descibe the laws concerning this problem either from the view of dangerous substances or from the view of dangerous waste. Furthermore in the thesis the data taken out of two age groups by questionnaires were elaborated. The questionnaires were focused on the knowledge of dangerous substances and dangerous waste. Toxicological characteristics of dangrous metals are also descbibed in this part.
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Imprisonment of minor offenders
VÁVROVÁ, Kateřina
Youth criminality is a constant problem which a number of specialists, legislative bodies, and the whole public deal with. A number of negative phenomenons occurring in the area of this population, e.g. spreading of drugs among younger and younger age groups and related increase of criminality undoubtedly play a leading role. However, it is known that bare repression is ineffective and means of educational activities are much more effective. Occurrence of social pathological phenomenons, their dynamics and changes are an indivisible part of the society. Grounds enabling occurrence of these phenomenons change very little. Heritability, constitutional factors, family, school, peer pressure, inappropriate spending free time as well as media influence and ethnical origin have an impact. Responsibility of the youth for unlawful acts is laid down by the Act No. 218/2003 Coll., on the Liability of Youth for Unlawful Acts and on Justice in Matters of Youth and Amending Certain Acts (Act on Justice in Matters of Youth). The purpose of the Act is defined particularly from the view of prevention of unlawful activities of the youth that is a basic group to which the attention of the whole justice and society is to be paid, so that every member of this group who committed an illegal act, no matter he is a juvenile or a child younger than fifteen years, is treated in accordance with this Act, he contributes to rectifying the injury resulting from the unlawful act within his strengths and abilities, a convenient and appropriate measure is imposed on him, and he finds a social asserting corresponding to his abilities and intellectual and moral development as a definitive result. Preventive activities aimed against youth criminality always and in the whole scope require respecting basic children rights and rights for privacy of their family. Children rights must be observed from primary to tertiary prevention, from searching threatened children and their families to treatment of guilty children. The most significant tool of social prevention is education of children in families and education of children at school. The aim of the thesis was to find out grounds leading to custodial detention of a juvenile offender and to find indications which could help to positively or negatively affect educational impact on the juvenile in the prison.
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