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Detrending heart rate variability signal with empirical mode decomposition EMD
Foltová, Anežka ; Janoušek, Oto (referee) ; Kubičková, Alena (advisor)
HRV analysis is an important indicator of pathophysiological examination. R-R waves are used for detection and analysis of ECG interval. R-R intervals can be analyzed by various methods. During spectral analysis is an often phenomenon disturbing non-stationary trend, which needs to be removed. In this paper, which deals about detrending, is mainly introduced Empirical mode decomposition (EMD) which is popular in recent years. Subsequently, this method is being compared to the method of wavelet transformation and Smoothness prior apprach (SPA).
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The revision of the cadastre in the cadastral unit of Jundrov
Kubíčková, Alena ; Matějík, Miroslav (referee) ; Berková, Alena (advisor)
This thesis deals with the revision of the cadastre data in the cadastral area of Jundrov. The area of interest is only a part of the cadastral territory, which is classified by the Cadastral Office Brno - město. The revision of the cadastre data was carried out in accordance with Section 35 of Act no. 256/2013 Sb. on Real Estate Cadastre (Cadastral Act) and Section 43 of Act no. 357/2013 Sb. on land registry (cadastral decree). The result of the master’s thesis is a copy of the cadastral map with inconsistencies drawn, a list of discrepancies found, annexes to the protocol on the result of revision of the cadastre data.
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Noise map
Lokaj, Jiří ; Kubičková, Alena (referee) ; Rozman, Jiří (advisor)
The aim of this paper is to introduce the measurement of noise and create a noise map in a geographic information system. The first part is focused on describing the physical properties of sound in space, atmospheric and physiological acoustics. It also deals with the physiological effects of noise on the human body and technology needed for measure and process noise. Other part describes the structure of a geographic information system and noise map. The last part is about the practical creation of noise maps, includes a description of the real measurement results and evaluation
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Muscle noise filtering in ECG signals
Novotný, Jiří ; Kubičková, Alena (referee) ; Smital, Lukáš (advisor)
This master's thesis deals with the optimization of numerical coefficients of the Wiener filter for muscle noise filtering in ECG signals. The theoretical part deals with ECG signal characteristic and muscle interference. It also contains a summary of the wavelet transform, wavelet Wiener's filtration, methods for calculating of the threshold and thresholding. In the last theoretical part the characteristic optimization techniques, the exhausive search and Nelder-Mead simplex method are mentioned, which were implemented in the practical part of this thesis in MATLAB. The functional verification and Wiener's filter optimization were tested on the standard electrocardiograms database CSE. By using the methods of exhausive search, the initial estimate for the solution method Nelder-Mead was obtained. The optimization method Nelder-Mead gives better results in the orders of hundredths or tenths than the method of exhausive search. The practical part is finished by the comparison of results of implemented algorithm with optimum coefficients, implemented in this thesis, with the results of other methods for filtering muscle interference in ECG signals.
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Automatic Analysis of Heart Rate Variability Signals
Kubičková, Alena ; Halámek, Josef (referee) ; Lhotská, Lenka (referee) ; Kozumplík, Jiří (advisor)
This dissertation thesis is dedicated to the heart rate variability and methods of its evaluation. It mainly focuses on nonlinear methods and especially on the Poincaré plot. First it deals with the principle and nature of the heart rate variability, then the ways of its representation, linear and also nonlinear methods of its analysis and physiological and pathophysiological influence on heart rate variability changes. In particular, there is emphasis on the metabolic syndrome. In the next section of the thesis there are compared and evaluated different ways of representation of the heart rate variability and further are tested selected methods of heart rate variability analysis on unique data from patients with the metabolic syndrome and healthy subjects provided by the Institute of Scientific Instruments, Academy of Sciences of Czech Republic. In particular, they are used the Poincaré plot and its parameters SD1 and SD2, commonly used time domain and frequency domain parameters, parameters evaluating signal entropy and the Lyapunov exponent. SD1 and SD2 combining the advantages of time and frequency domain methods of heart rate variability analysis distinguish successfully between patients with the metabolic syndrome and healthy subjects.
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Characterization of low-molecular-mass synthetic markers of isoelectric points by capillary zone electrophoresis and capillary isoelectric focusing
Brandejsová, Martina ; Kašička, Václav (advisor) ; Kubíčková, Anna (referee)
High-performance electromigration separation methods, capillary zone electrophoresis (CZE) and capillary isoelectric focusing (CIEF), have been applied to physico-chemical characterization of new synthetic low-molecular mass markers of isoelectric points. Amphoteric compounds on the basis of aminomethylnitrophenols, their derivatives and other structurally related substances were analyzed by CZE in a series of background electrolytes in a wide pH range, 1.86 - 11.18. From the measured pH dependencies of effective electrophoretic mobilities of analytes (beforehand corrected to reference temperature of 25 řC), their isoelectric points (pI) were determined. In addition, using the non-linear regression analysis of the above dependencies, acid-base dissociation constants (pKa) of ionogenic groups of selected analytes were calculated. Subsequently, the analytes with sharply defined isoelectric points were analyzed by CIEF. CIEF confirmed applicability of these compounds as markers of isoelectric points for calibration of pH gradient in CIEF in the determination of pI of amphoteric compounds, especially peptides and proteins. The determined pKa values of ionogenic groups in particular compounds will be utilized in the development of new pI markers with desired pI values.
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The issue of child soldiers in international law with regard to the African regional regulation
Kubíčková, Anna ; Honusková, Věra (advisor) ; Bayerová, Monika (referee)
The main purpose of this thesis was to give a general overview of the problem of child soldiers and their protection among international law conventions and among regional law agreements with the focus on the African continent. The use of child soldiers in armed conflict is qualified as one of the worst forms of child labour.The majority of child soldiers are active in Africa and, to a lesser extent, in the Middle East and Asia. Besides introduction and conclusion, the study consists of five chapters. The first chapter describes the protection of child soldiers on the international level. Therefore it is focused on individual conventions, especially on Geneva Conventions, Additional Protocols to the Geneva Conventions, the Convention on the Rights of the Child, the Optional Protocol to the Convention on the Rights of the Child on the involvement of children in armed conflict, the Optional Protocol to the Convention on the Rights of the Child on a Communications Procedure, but as well on the International Labour Convention No. 182 or the Rome Statute. The soft law represents Paris principles. Discussed is particularly the question of the age limit for child participation in armed conflict. The second chapter is concerned with the international control mechanisms, resulting from the above-mentioned...
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Development of Electrochemical Thin-layer Degradation Cell for Oxidation Stress Testing of Active Pharmaceutical Ingredients
Šefčík, Martin ; Kubíčková, Anna (advisor) ; Coufal, Pavel (referee)
In this thesis, the oxidation conditions in a new electrochemical "thin-layer" flow-through cell for the study of the oxidative degradation of active pharmaceutical ingredients were optimized. In this field, it is an innovative approach to studying the oxidation properties of substances. The cell was manufactured using 3D printing technology. Oxidation was carried out in a two-electrode arrangement with a working boron-doped diamond electrode (BDDE) and an auxiliary stainless steel electrode. Optimization of conditions was performed using salicylic acid as a model active pharmaceutical ingredient. The electrochemical approach was used to degrade this active pharmaceutical ingredient by the required approximately 20% of the original amount in only 2.3 min. Thus, the degradation time was significantly reduced compared to the oxidative stability stress tests of active pharmaceutical ingredients commonly used today. Two major degradation products were observed, namely gentisic acid and 2,3-dihydroxybenzoic acid. The degradation products obtained by electrochemical oxidation and chemical oxidation using hydrogen peroxide are identical.
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