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Modulation of pKa of the recognition moiety of azaphthalocyanine sensors
Čermáková, Veronika ; Zimčík, Petr (advisor) ; Zitko, Jan (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Chemistry and Pharmaceutical Analysis Candidate: Veronika Čermáková Supervisor: Assoc. Prof. Petr Zimčík, Ph.D. Title of Diploma Thesis: Modulation of pKa of the recognition moiety of azaphtalocyanine sensors Azaphthalocyanines (AzaPc) are macrocyclic compounds containing a large system of conjugated double bonds that enables them to absorb light in the red part of the spectrum that is promising in biological applications. They are characterized by intense red fluorescence as one of the relaxation pathways of the excited state after absorbing a photon. The fluorescence of AzaPc substituted with a phenol moieties on the periphery can be switched ON/OFF depending on the pH of the environment and the pKa of the phenolic group. In basic medium, the molecule occurs as phenolate and undergoes intramolecular charge transfer between the phenolate group (a donor) and the electron- deficient macrocyclic core (an acceptor). As a consequence of this process, the fluorescence is quenched. Switching between ON/OFF states in phenol-substituted AzaPc is dependent on the proton concentration and thus can be utilized in pH sensing. The aim of this work was to synthesize derivatives of phenol-substituted AzaPcs whose pKa is...
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Modulation of pKa of the recognition moiety of azaphthalocyanine sensors
Čermáková, Veronika ; Zimčík, Petr (advisor) ; Zitko, Jan (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Chemistry and Pharmaceutical Analysis Candidate: Veronika Čermáková Supervisor: Assoc. Prof. Petr Zimčík, Ph.D. Title of Diploma Thesis: Modulation of pKa of the recognition moiety of azaphtalocyanine sensors Azaphthalocyanines (AzaPc) are macrocyclic compounds containing a large system of conjugated double bonds that enables them to absorb light in the red part of the spectrum that is promising in biological applications. They are characterized by intense red fluorescence as one of the relaxation pathways of the excited state after absorbing a photon. The fluorescence of AzaPc substituted with a phenol moieties on the periphery can be switched ON/OFF depending on the pH of the environment and the pKa of the phenolic group. In basic medium, the molecule occurs as phenolate and undergoes intramolecular charge transfer between the phenolate group (a donor) and the electron- deficient macrocyclic core (an acceptor). As a consequence of this process, the fluorescence is quenched. Switching between ON/OFF states in phenol-substituted AzaPc is dependent on the proton concentration and thus can be utilized in pH sensing. The aim of this work was to synthesize derivatives of phenol-substituted AzaPcs whose pKa is...
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Evaluation of the Company´s Financial Performance using Benchmarking Approach
Čermáková, Veronika ; Pribyl, Peter (referee) ; Bartoš, Vojtěch (advisor)
This thesis deals with the evaluation of the performance of Ziehl-Abegg, s.r.o (Ltd.) The first part looks into the issues of evaluating the company's performance from the theoretical point of view. The analytical part takes a closer look at the company in question using it to carry out a strategic analysis and subsequently a comparison of various indicators is made against the company's competitors. Based on the escertained facts and analysis made, various measures are proposed aimed at improving the company's situation.
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Optimalizace zařazování prasniček do reprodukce
Čermáková, Veronika
The aim of the thesis was to analyze the marshaling gilts for breeding. The experiment contains two groups of gilts. First group included gilts from own production, second gilts were purchased. Main goal was evaluation of pregnancy length, age in first pregnancy, in first due date and assess the numbers all born piglets, live- born piglets, stillborn piglets and mummified piglets in the litter from the first parity sows. Gilts were also analyzed for reproduction, depending on breeding age or age in purchasing period. According to that results, we did evaluation for selected indicators of reproduction like gravidity length, all born piglets, live-born piglets, stillborn piglets and mummified piglets in a litter. As we can see from results, the highest number of all newborn piglets achieve gilts from own production, namely 13,70 DC. Gilts in own production gave us higher number of live born piglets, 12,74 DC but they have lower number of stillborn piglets, specifically 0,61 DC. Gilts, which were purchased, have lower number of mummified piglets 0,04 DC. The length of gilts pregnancy were the same in both groups, average is 115 days. First service of gilts in own production was 238,02 days, in group of purchased gilts it was 247,65 days. Averadge age for first birth in own production group was 353,66 days, purchased group 363,32 days.
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Modulation of pKa of the recognition moiety of azaphthalocyanine sensors
Čermáková, Veronika ; Zimčík, Petr (advisor) ; Zitko, Jan (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Chemistry and Pharmaceutical Analysis Candidate: Veronika Čermáková Supervisor: Assoc. Prof. Petr Zimčík, Ph.D. Title of Diploma Thesis: Modulation of pKa of the recognition moiety of azaphtalocyanine sensors Azaphthalocyanines (AzaPc) are macrocyclic compounds containing a large system of conjugated double bonds that enables them to absorb light in the red part of the spectrum that is promising in biological applications. They are characterized by intense red fluorescence as one of the relaxation pathways of the excited state after absorbing a photon. The fluorescence of AzaPc substituted with a phenol moieties on the periphery can be switched ON/OFF depending on the pH of the environment and the pKa of the phenolic group. In basic medium, the molecule occurs as phenolate and undergoes intramolecular charge transfer between the phenolate group (a donor) and the electron- deficient macrocyclic core (an acceptor). As a consequence of this process, the fluorescence is quenched. Switching between ON/OFF states in phenol-substituted AzaPc is dependent on the proton concentration and thus can be utilized in pH sensing. The aim of this work was to synthesize derivatives of phenol-substituted AzaPcs whose pKa is...
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The Role Of The Roma Advisor in The Process Of Community Planning
ČERMÁKOVÁ, Vendula
My bachelor thesis is divided into two parts, theoretical and research. In the first theoretical part I tried to describe and explain basic terms such as community planning of social services and Roma adviser. In the second part I try to fulfill the aim of the work through qualitative research, which is to find out the role of the Roma advisor in the process of community planning and answer the research question: Is the position of the Roma advisor important for community planning? The qualitative research was carried out using the method of questioning and using a semi-structured interview. The research group consists of Roma advisors from the South Bohemian Region. The research part also includes the methodology of work, especially the description of data collection and processing. The results of the interviews are then evaluated.
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Beuron Art in the Emmaus Monastery
Čermáková, Veronika ; Foltýn, Dušan (advisor) ; Jarošová, Markéta (referee)
The bachalor's thesis "Beuron Art in the Emmaus Monastery" examines an unique phase in the history of Emmaus Monastery influenced by Beuron Art. It presents to reader a preview of the artistic transformation of the monastery from 1880 until it's critical destruction on February 14, 1945, when became to unwanted object of the bombing of Prague. We can find out about the monastery restoration process realized in the following years. Another part of the bachelor's thesis gives us general information about Beuron Art School and it's main representatives. Then it shows the significance of this artisitic style and maps it's other artworks in Prague. Keywords Beuron, Beuron Congregation, Beuron Art School, Emmaus Monastery, OSB, sacral interior
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Proposal of the Debt Collection Improvement in the Enterprise
Čermáková, Veronika ; Vrbovský, Tomáš (referee) ; Musilová, Helena (advisor)
This bachelor thesis deals with the issue of securing and collecting past due claims in the Ziehl – Abegg s.r.o. company. The theoretical part defines receivables, how they are created and secured from the legal, tax, accounting and economic point of view. The analytical part then analyzes past due claims of a designated subject. Based on the gathered information, suggestions on more effective collection of claims are introduced.
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Respiration as an interdisciplinary topic in science education
Čermáková, Vendula ; Teplá, Milada (advisor) ; Distler, Petr (referee)
This diploma thesis is focused on topics of and respiratory chain and their processing as educational animations for secondary schools. In the theoretical part of the diploma thesis, supporting terms are defined (visualisations, interdisciplinary relations, animations). Next, themes are included in educational field and thematic unit in RVP G. Two analyses of the topic of respiratory chain are mentioned and evaluated in this part. Firstly, there is an analysis focused on the most used chemical and biological textbooks. The second one is focused on available online animations. For research purpose of the diploma thesis quantitative method was used - a questionnaire survey. Results of this survey are listed in the practical part. Practical part presents educational materials specified for support of education topics of respiration and respiratory chain. Stress on illustrative nature and interdisciplinarity is laid in these materials. The principal materials are educational animations which were made in program Adobe Flash Professional CS6. Study text was also written to these animations. Created educational animations give a complex view on respiratory process. These materials can be used in biology and chemistry subjects or in scientific courses. Animations include two tests giving feedback to...
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