|
|
Assessment of quality of life of patients with epilepsy using QOLIE-31.
Zývalová, Aneta ; Vlček, Jiří (advisor) ; Kubová, Hana (referee)
1 UNIVERZITA KARLOVA V PRAZE FARMACEUTICKÁ FAKULTA V HRADCI KRÁLOVÉ Katedra sociální a klinické farmacie Hodnocení kvality života pacientů s epilepsií pomocí dotazníku QOLIE-31 Assessment of quality of life of patients with epilepsy using QOLIE-31 Diplomová práce Vedoucí diplomové práce: Doc. RNDr. Jiří Vlček, CSc. HRADEC KRÁLOVÉ 2007 Aneta Zývalová 2 Prohlašuji, že jsem diplomovou práci vypracovala samostatně, s použitím uvedené literatury. 3 Děkuji Mgr. Evě Tlusté za obětavou pomoc při psaní diplomové práce. Její odborné zkušenosti, praktické připomínky a vstřícný přístup mi byly velmi nápomocné. Dále bych ráda poděkovala doc. RNDr. Jiřímu Vlčkovi, CSc. za odborné vedení. V neposlední řadě bych ráda poděkovala celé své rodině, která mi byla oporou během celého studia. 4 Obsah 1. ÚVOD A CÍL PRÁCE ....................................................7 2. REŠERŠNÍ ČÁST.........................................................8 2.1. EPILEPSIE .............................................................................. 8 2.1.1. Definice ................................................................................ 8 2.1.2. Historie ................................................................................. 8 2.1.3. Epidemiologie...
|
|
|
Analysis of treatment of patients with epilepsy dispenzarized in University Thomayer's Hospital in Prague.
Frýdlová, Dana ; Vlček, Jiří (advisor) ; Kubová, Hana (referee)
Analysis of treatment of patients with epilepsy dispenzarized in University Thomayer's Hospital in Prague Student: Frýdlová D. Tutor: Vlček J., Tlustá E. Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Kralove, Charles University in Prague, Czech Republic Background: Studies on antiepileptic drug utilization are important for evaluation of epilepsy treatment and risk of antiepileptic drugs (AEDs). Aim: To describe group of patients with epilepsy, AEDs utilization patterns and adverse drug reactions (ADRs) of AEDs. Methods: Data were retrieved from medical records in University Thomayer's Hospital in period 2005 - 2006. Epileptic outpatients (n = 97) aged over 16 years were considered for analysis. Results: The age ranged from 17 to 72 years (mean 55), 62 % were women. Partial seizures were diagnosed in 62 % of patients. 31 % of patients were more then 2 years without seizures, 39 % of patients had more then 12 seizures per year. More then half (65 %) of the patients were treated with polytherapy. Lamotrigin was the most commonly prescribed AED (20 %), followed by valproate (18 %) and carbamazepine (17 %). The most frequently prescribed AED in monotherapy was valproate, followed by lamotrigin, carbamazepine and levetiracetam. The ADRs were recorded in 41 patients. The most...
|
|
|
The influence of status epilepticus (SE) in postnatal development early phase on laboratory rat psychomotor development
Boťchová, Lenka ; Kubová, Hana (advisor) ; Mareš, Pavel (referee)
Bibliografická identifikace v angličtině Author's first name and surname: Lenka Boťchová, BA Title of the master thesis: Does status epilepticus during early postnatal period influence laboratory rat psychomotor development? Department: Department of Rehabilitation and Exercise Medicine Supervisor: doc. PharmDr. H. Kubová, DrSc. The year of presentation: 2013 Abstract: The purpose of this study is to evaluate the influence of status epilepticus (SE) in postnatal development early phase on laboratory rat psychomotor development. Experimentally caused (SE) is the most common mode of epileptogenesis, which is the process leading to the epilepsy creation, and typical comorbidities. The influence of the early SE was studied when using lithium/pilocarpine model of SE induced on 12 days old rat cubs, which were repeatedly exposed to the "open field" test until 32nd day of their lives that means until the puberty beginning. The evaluation is focused on cognition and overall locomotion changes and anxiety demonstrations. The results show that in short periods after SE (up to 1 month) the cognitive functions regarding the habituation disorder are not worsened. However, hyperactivity short-term disposition and worse adaptability to experimental conditions due to animal anxiety increase were detected. Motor skills of...
|
|
|
Effects of early life stress on brain development
Hanišová, Lucie ; Kubová, Hana (advisor) ; Hejnová, Lucie (referee)
Adverse life experience during so called critical developmental periods is known to exert detrimental effects on central nervous system. Early stress may predispose to cognitive impairment, depression or other mental problems as well as to aggravation of existing neuropsychiatric problems. Consequences of early stress are highly age-dependent and affected by sex, genetic predispositions and type of stressor. In addition to prenatal stages, also postpartum period and adolescence are considered as periods of increased sensitivity to environmental disturbances of various origins (chemical, hormonal, physical and particularly social). Utilization of animal models is a direct approach to find out whether exposure to specific stressor alters mental functions and increases risk of behavioral problems. Animal studies also enable to study stress-induced molecular, cellular and structural changes and their role in later development of behavioral alterations.
|
|
|
Consequences of early ischemic hippocampal lesion in rats
Mátéffyová, Adela ; Kubová, Hana (advisor) ; Mareš, Jan (referee) ; Brázdil, Milan (referee) ; Kozler, Petr (referee)
Stroke is an important cause of neurological morbidity in infants and children, with an incidence of approximately 8 cases per 100000 per year (Giroud et af. 1995). In chi ldren, stroke is often under-recognized/unrecognized because of variation in the presentation, evaluation, and diagnosis. In many cases, asyrnmetry of reaching and grasping, failure to reach developmental milestones, or post-neonatal seizures that appear some months after the acute event are the only mark of previous stroke. Powered by TCPDF (www.tcpdf.org)
|
|
| |
|
| |
|
| |
|
|
Hippocampal neurogenesis in the adult brain and its changes in neuropsychiatric diseases
Brukhnová, Alena ; Kubová, Hana (advisor) ; Červená, Kateřina (referee)
The aim of my thesis is to summarize the information about neurogenesis in the dentate gyrus of the hippocampus in the adult brain. I examine the process of maturation, migration of immature neurons and functional significance of neurogenesis in the area. In the adult brain it is very important for proper spatial perception and learning. In the next chapter I focus on some significant neurodegenerative and neuropsychiatric diseases such as epilepsy, Alzheimer's disease or depression. During each of them leads to diverse changes and bnormalities in neurogenesis in hippocampal area. Powered by TCPDF (www.tcpdf.org)
|
|
|
Role of neurogenesis in development of epilepsy and epileptic co-morbidities.
Černíková, Nela ; Kubová, Hana (advisor) ; Telenský, Petr (referee)
Production of new neurons from stem/proliferating cells in the mammalian brain is maintained through all life and it is closely associated with formation of memory as well as other behavioural functions. In mature brain, changes in neurogenesis play critical role in development of some neuropsychatric diseases like epilepsy, depression, anxiety and others. Even though epilepsy starts early in life in 50% of patients, possible association between impairment of neurogenesis seen in epileptic brain and occurrence of psychiatric diseases is studied only in adult brain.
|
guest ::
RSS feed.