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Complex chromosomal aberrations in bone marrow cells of adult patients with myelodysplastic syndromes (MDS): frequency, mechanism of origin and clinical significance.
Rochlová, Kristina ; Zemanová, Zuzana (advisor) ; Novotná, Drahuše (referee)
Complex chromosomal aberrations occurs are described in approximately 20 % of patients with myelodysplastic syndrome (MDS) and are associated with a poor prognosis. Nevertheless, the mechanism and possible causes responsible for the emergence of these aberrations are not fully understood. There are two models describing the emergence of these aberrations, namely shattering of single chromosomes or their parts during the so-called cellular crisis (chromothripsis) and/or progressive accumulation of chromosomal aberrations during the course of the disease (clonal evolution). Using combination of cytogenomic methods we examined 61 samples of bone marrow from adult patients with MDS and a complex karyotype. Unbalanced aberrations with loss of genetical material were found in most cases. Chromosomes 5, 7 and 12 were most frequently involved in rearrangements. Clonal development, chromothripsis and both mechanism was detected in 26, 12 and 14 patients, respectively. Patients with deleted chromosome 5 included in complex karyotype had the shortest overall survival. The cause of emergence of complex aberrations did not affect survival. Cytogenomic analysis of complex aberrations allows detection of balanced and unbalanced changes and identification of important processes of tumorigenesis such as clonal...
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Kvalita služeb v zábavních tematických parcích
Novotná, Daniela
Novotná, D. Service quality at amusement and theme parks. Diploma thesis. Brno: Mendel University, 2020. This diploma thesis deals with the most important key service quality factors at amusement and theme parks in the Czech Republic from the point view of visitors. There are used secondary and primary data for the classification of these factors. Also the environment and offer of entertainment in theme parks in the Czech Republic is characterized. The primary research is concerned with the level of service and quality of a particular theme park with regard to visitors´ satisfaction and loyalty. For the rating of satisfaction is used SERVQUAL and IPA analysis. Based on these results, general recommendations are established for the theme park management and also possibly for the destination management. Moreover, the park management will gain information about visitors and their preferences from this evaluating survey. According to these data of the quality level in the chosen theme park there are taken specific measures for increasing the satisfaction and loyalty of visitors.
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Physiotherapy in dysmenorrhea
Novotná, Dominika ; Havlíčková, Michaela (advisor) ; Ježková, Martina (referee)
Bibliographical report NOVOTNÁ, Dominika. Physiotherapy in dysmenorrhea. Prague: Charles University, 2nd Faculty of Medicine, Department of Rehabilitation and Sports Medicine, 2022. 110 pages, 7 attachments. Thesis supervisor Mgr. Michaela Havlíčková. Abstract The theme of this bachelor's thesis is dysmenorrhea, one of a common problems in women. Physiology of the menstrual cycle and the effect of sex hormones on the female body, description and pathogenesis of primary and secondary dysmenorrhea, pain and its connection to the cycle are all included in the theoretical part as well as functional disorders of the musculoskeletal system typically found in patients suffering from dysmenorrhea. Theoretical part then stresses the importance of differential diagnosis between primary and secondary dysmenorrhea and is concluded by a summary of individual methods and concepts used in the therapy of both primary and, if possible, secondary dysmenorrhea. Knowledge from the theoretical part is then used in the practical part: case report of a patient with primary dysmenorrhea which contains of kinesiological analysis and therapy using selected methods of physical therapy. Keywords Primary dysmenorrhea, secondary dysmenorrhea, menstrual cycle, pain, physiotherapy . I agree the thesis paper to be lent within the library...
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Possibilities of Using Regional Objects for Technical Excursions at Primary School
NOVOTNÁ, Dominika
This diploma thesis is focused on selected technical monuments in the Pelhřimov region and their aplication in teaching at primary school. The theoretical part of thesis is focussed on technical education and its aims of education at primary school, activating learning methods, its classification and characterization. Next part concern of Framework Educational Programme for Basic Education in the area Humans and Their World and Humans and Their World of Work, there are characteristics of selected object of Pelhřimov region. The project part will introduce particular excursions for primary school pupils. Some of them were verified at school, some of them online but some have not been verified due to coronavirus pandemic situation. The diploma thesis contains of preparations of excursions which were verified and worksheets and its correct solutions.
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Poor posture in school-age children and possibilities of physiotherapeutical influence
NOVOTNÁ, Dominika
This bachelor's thesis deals with poor posture of school-age children and the possibilities of physiotherapeutic influence. Poor posture is becoming more and more topical and number of children with poor posture is increasing. One of the most common causes is the inappropriate lifestyle of today's children, when children spend most of the day sitting at school and then at home at the computer or television. The bachelor thesis is divided into theoretical and practical part. The theoretical part deals with the anatomy of the musculoskeletal system, more precisely the spine, pelvis and legs. The next chapter describes correct and defective posture, how defective posture can be investigated and factors influencing poor posture. The last chapter of the theoretical part contains the characteristics of school age. The main goal of this bachelor's thesis is to design our own exercise unit for school-age children with poor posture, which is then used for exercise with three probands with poor posture. This exercise unit was processed into an educational brochure and attached to the bachelor's thesis. A partial goal of the work is the analysis of the most common causes of poor posture of children and another partial goal is to propose prevention of this problem. The practical part was carried out in the form of qualitative research. The research includes three school-age probands with whom the therapy was done according to my proposed exercise unit. The practical part contains anamnesis, initial kinesiological analysis and descriptions of individual therapies. The therapies took place from the beginning of February 2020 to the middle of April 2020, when a joint therapy took place every week and the rest of the week the probands had to train at home according to the exercise brochure and exercises they learned on the therapy. All patients have improved, so research shows that therapy for children with poor posture is beneficial, but probands must continue the learned exercise to improve their posture significantly. This work can be used as an educational material for children and parents, or in the clinical practice of physiotherapists.
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Using the CLIL method for preparation of selected topics from Human Physiology at lower-secondary level
NOVOTNÁ, Denisa
Diploma thesis deals with the use of the CLIL method in biology lessons and its using for preparation of selected topics from Human Biology at lower-secondary level. The aim of the thesis was to study Czech and foreign literature which is concentrated on CLIL method and its integration into the Biology teaching, further was described the characteristics of this teaching method and were included the concrete examples of using this method in teaching lessons. The main aim of the thesis was to design and verify two teaching units in the field of Human Biology teaching at lower-secondary level. Within each teaching unit students solved a practical task from Biology, and they also acquired knowledge and vocabulary related to a concrete topic. Based on the verification of teaching units in practice was developed methodical recommendations for teachers interested in introducing the CLIL method into their lessons. The analysis of the pupil's worksheets showed that pupils were able to do most of the tasks on their own however certain activities caused problems to them and therefore was needed more guidance from the teacher. The instructions of some activities were necessary to repeat several times due to elimination of possible mistakes in pupil's worksheets. Observing the experimental teaching it was found out that the majority of students did not have difficulty to communicate in English about issues related to selected biological topics and the foreign language was not an obstacle for them in understanding the content of the subject. The important information was told in the mother tongue because of the less language-skilled pupils.
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Experiential education prevention to care for abandoned animals
NOVOTNÁ, Denisa
Novotná D., 2018: Experiential education prevention to care for abandoned animals. Bachelor thesis. Faculty of Education, University of South Bohemia in České Budějovice, České Budějovice, 42 p. This bachelor thesis deals with prevention in the care of abandoned animals in the form of experience. The aim of this bachelor thesis is to observe and evaluate the annual operation of the City shelter for abandoned and found animals in Jihlava. Another task was to design and realize experience-based preventive program for primary school pupils in a shelter in Jihlava. Initially, the work describes and characterizes dog, then there are explained the steps that have to be followed when someone finds an abandoned animal and there are also conditions of adopting dog from the shelter. The bachelor thesis mentions what is related to the concept of experience pedagogy and also presents some basic principles for safe contact between children and a dog.
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