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Business Plan
Francová, Iveta ; Šmíd, Ondřej (referee) ; Mikulec, Luděk (advisor)
For the realization of the business plan is issued from the request of the business subject founder, in this case Limited Liability Company. Further will in connection with herewith intention submitted proposal for the methodical plan creation. This plan includes detailed specification necessary progress for realization hereof intention, evaluation of the proposed suggestions and groundwork and implementation schedule.
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The essential processes of FeS cluster assembly and mitochondrial protein import in parasitic protists
Šmíd, Ondřej
CONCLUSIONS Mitochondria appear to be vital organelles for all eukaryotic organisms known to date. A large body of evidence strongly indicates that hydrogenosomes and mitosomes, the organelles of anaerobic or intracellular parasitic protists lacking the "typical" mitochondria, are only a variation on the mitochondrial theme. However, even though the three organelles are evolutionarily the same entity, remarkable differences exist between them that reflect the adaptation of the organisms to their specific niches. In the thesis I tried to unravel some aspects of the essential mitochondrial processes of FeS cluster assembly and mitochondrial protein import in parasitic protists T. brucei and G. intestinalis. We investigated the function of the T. brucei cysteine desulfurase IscS and the scaffold protein IscU. We demonstrated that the two proteins are essential for FeS cluster formation and consequently the viability of the procyclic stage of T. brucei. Even though both IscS and IscU were specifically localized to the mitochondrion, their deficient expression affected the maturation of FeS proteins operating not only in the mitochondrion, but also in the cytosol. This indicates that a crucial part of FeS cluster assembly is localized to the mitochondrion of T. brucei. One of the major differences between the T....
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The essential processes of FeS cluster assembly and mitochondrial protein import in parasitic protists
Šmíd, Ondřej
CONCLUSIONS Mitochondria appear to be vital organelles for all eukaryotic organisms known to date. A large body of evidence strongly indicates that hydrogenosomes and mitosomes, the organelles of anaerobic or intracellular parasitic protists lacking the "typical" mitochondria, are only a variation on the mitochondrial theme. However, even though the three organelles are evolutionarily the same entity, remarkable differences exist between them that reflect the adaptation of the organisms to their specific niches. In the thesis I tried to unravel some aspects of the essential mitochondrial processes of FeS cluster assembly and mitochondrial protein import in parasitic protists T. brucei and G. intestinalis. We investigated the function of the T. brucei cysteine desulfurase IscS and the scaffold protein IscU. We demonstrated that the two proteins are essential for FeS cluster formation and consequently the viability of the procyclic stage of T. brucei. Even though both IscS and IscU were specifically localized to the mitochondrion, their deficient expression affected the maturation of FeS proteins operating not only in the mitochondrion, but also in the cytosol. This indicates that a crucial part of FeS cluster assembly is localized to the mitochondrion of T. brucei. One of the major differences between the T....
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Nursing care of the patient with the diagnosis of acute myocardial infarction
Kubíčková, Vlasta ; Lálová, Ilona (advisor) ; Šmíd, Ondřej (referee)
Tématem mé bakalářské práce je ošetřovatelská péče o pacienta s diagnózou akutní infarkt myokardu. Práce byla vypracovaná formou případové studie u pacienta, který byl hospitalizován na II. interní klinice, koronární jednotce ve Všeobecné fakultní nemocnici. Práce je rozdělena na klinickou a ošetřovatelskou část. V klinické části jsem popsala anatomii srdce, diagnostiku, průběh, možnosti léčby a prognózu akutního infarktu myokardu. Ošetřovatelská část je věnována ošetřovatelskému procesu a modelu funkčního zdraví dle Marjory Gordonové. Z odebraných informací jsem stanovila ošetřovatelský plán. S ohledem na stav a potřeby pacienta jsem vybrala odpovídající ošetřovatelské diagnózy a zvolila jsem odpovídající edukaci. Závěr práce je věnován zhodnocení ošetřovatelské péče.
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The essential processes of FeS cluster assembly and mitochondrial protein import in parasitic protists
Šmíd, Ondřej ; Tachezy, Jan (advisor) ; Hampl, Vladimír (referee) ; DYALL, Sabrina D. (referee)
CONCLUSIONS Mitochondria appear to be vital organelles for all eukaryotic organisms known to date. A large body of evidence strongly indicates that hydrogenosomes and mitosomes, the organelles of anaerobic or intracellular parasitic protists lacking the "typical" mitochondria, are only a variation on the mitochondrial theme. However, even though the three organelles are evolutionarily the same entity, remarkable differences exist between them that reflect the adaptation of the organisms to their specific niches. In the thesis I tried to unravel some aspects of the essential mitochondrial processes of FeS cluster assembly and mitochondrial protein import in parasitic protists T. brucei and G. intestinalis. We investigated the function of the T. brucei cysteine desulfurase IscS and the scaffold protein IscU. We demonstrated that the two proteins are essential for FeS cluster formation and consequently the viability of the procyclic stage of T. brucei. Even though both IscS and IscU were specifically localized to the mitochondrion, their deficient expression affected the maturation of FeS proteins operating not only in the mitochondrion, but also in the cytosol. This indicates that a crucial part of FeS cluster assembly is localized to the mitochondrion of T. brucei. One of the major differences between the T....
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Business Plan
Francová, Iveta ; Šmíd, Ondřej (referee) ; Mikulec, Luděk (advisor)
For the realization of the business plan is issued from the request of the business subject founder, in this case Limited Liability Company. Further will in connection with herewith intention submitted proposal for the methodical plan creation. This plan includes detailed specification necessary progress for realization hereof intention, evaluation of the proposed suggestions and groundwork and implementation schedule.
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