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Changes in ventilatory parameters in survivors after severe COVID-19 associated pneumonia
Kulhánková, Adéla ; Gojda, Jan (advisor) ; Mlček, Mikuláš (referee)
Background and Aims COVID-19 disease can cause severe bilateral pneumonia which manifests as a restrictive pulmonary disease in the post-acute phase, raising the question of whether this post-acute impairment may persist and lead to long-term consequences. The aim of this thesis was to find out whether patients in the post- acute phase of COVID-19 suffer from respiratory disorders and possibly whether these disorders persist even after 6 months, using the analysis of spirometry data, such as vital capacity (VC), forced vital capacity (FVC), and Tiffeneau index (FEV1/FVC). Methods A retrospective analysis of the prospective cohort COMETA study examining patients with confirmed bilateral COVID-19 pneumonia was conducted. 42 patients were examined at baseline in the post-acute phase of COVID-19 (visit A) and 36 of them participated also in the examination after 6 months (visit C). The Student's t- test was used to compare parameters with a normal distribution. For the parameters with non-normal distribution, the Mann-Whitney test was used. Results At the baseline, the median VC and FVC were below 80 % of their predicted values. A statistically significant improvement over the course of 6 months was observed for the VC of males (Δ median 0.7900, p <0.01) and females (Δ mean 0.4692 p < 0.05) and FVC of...
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Influence of the posture's change on respiratory function in spinal cord injury patients.
Pavlikhina, Ekaterina ; Vilímek, Miloslav (advisor) ; Šorfová, Monika (referee)
Author: Bc. Pavlikhina Ekaterina Title: Influence of the posture's change on respiratory function in spinal cord injury patients. Objectives: The purpose of this thesis is to analyze change in respiratory function on change of posture in patients with spinal cord injury (SCI). Another objective is to compare the respiratory functions in a health subjects and in a SCI patients. Last but not least is an effort to find out whether SCI patients have a pattern of restrictive pulmonary dysfunction. The findings can help understanding development of respiratory complications after spinal cord injury. It may help in choosing optimal position during respiratory examination and respiratory rehabilitation. Methods: In theoretical part, there were explored the available knowledges about respiratory complications and their effects on posture. In practical part, there were 26 subjects - 16 patients with SCI and 10 healthy subjects. Subjects with SCI were divided into two groups - one with paraplegia and other one with quadriplegia. Measurements were performed with spirometer on each subject during supine, sitting and standing postures. There were collected vital capacity (VC), forced vital capacity (FVC) and forced expiratory volume in first second (FEV1) data from all subjects. All data were processed in...
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