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Notch Interaction with Glycogen Synthase Kinase-3β in Neurodegenerative Disease
Traub, Teodor ; Mašek, Jan (advisor) ; Rozbeský, Daniel (referee)
Glycogen synthase kinase-3βeta (GSK-3β) is a serine/threonine protein kinase involved in a number of signaling processes. Pharmacological inhibition of GSK-3β has been shown to have neuroprotective effects, and its dysregulation is present in a variety of neurodegenerative, neuromuscular, developmental, and psychiatric disorders. GSK-3β is an essential component of the canonical Wnt pathway, which is involved in nervous system development. Notch signaling, like Wnt, plays a key role in development, but its relationship to GSK-3β remains unclear. The existing literature indicates that GSK-3 phosphorylates Notch intracellular domain but contradicts whether GSK3β affects Notch positively or negatively. Thus, such molecular "cross-talk" is highly complex and interactions may exist at multiple levels beyond simple phosphorylation with other components being involved. Myotonic dystrophy is a genetic neuromuscular disease that causes dysregulated protein expression of many proteins, including GSK-3β, and features developmental, muscle, and neurological symptoms. Studying molecular interactions in the context of myotonic dystrophy may help uncover effects that GSK-3β and Notch have on development and disease of nervous and muscular systems. This thesis presents a review of previous studies concerning the...
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New trends in fibre optic sommunications
Lubajo, Lubajo Moses Wolyan ; Dejdar, Petr (referee) ; Münster, Petr (advisor)
Přenos optickych vláken je jednou z hlavních metod přenosu informací pro přenos na velké vzdálenosti. Byly vyvinuty různé modulační formáty pro maximalizaci informací přenášenych prostřednictvím komunikačního kanálu. Takové formáty sahají od formátů, které přenášejí jeden bit na symbol (jako je například binární fázové posunování klíčů, BPSK), a nebo vice, jako je například Kvadraturní fázové posunovací klíčování, duální polarizační kvadraturní fázové řazení a mnoho dalších ostatní modulace. Cílem diplomové práce je vytvořit a implementovat přenosovy systém s rychlostí 100 Gbps pomocí modulace formátu DP QPSK. Vysledky jsou shrnuty s ohledem na to, co bylo úspěšně implementováno, a zlepšení, která mohou byt ještě učiněna pro zvyšení přenosové vzdálenosti a snížení BER mimo jiné. Použitysimulační software je PHOTOSS.
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Interconnects modelling for signals transmission
Fabián, Martin ; Petržela, Jiří (referee) ; Brančík, Lubomír (advisor)
In this work, there is solution for problem about signal itegrity and problems that causes raising frequence in circuits and machineries. There is describe interconnect analysis of models, which enable transfer of signals in mixed analog – digital circuits and a different between the analyse of an time domain and an s-domain. Next, there are described three methods of the calculation homogenous transmission line.The first method is constructed on mathematic description of transmission line. The second method uses cascade connection and T networks to the simulation model of the homogenous transmission line. The last one is constructed on the moment matching in use of state variables. These methods uses numerical inversion of Laplace transforms and these methods are constructed in programming language Matlab. Its results with the confrontation is described in the ending.
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Ethernet for metallic cables
Víteček, Aleš ; Člupek, Vlastimil (referee) ; Zeman, Václav (advisor)
The bachelor thesis "Ethernet for Metallic Cables" deals with the analysis of Ethernet technology, the most used technology for running computer networks. Specifically, it is focused on transmission via metallic line. The aim of this thesis is description of technology, research of the latest Ethernet standards, including the latest categories of metallic lines. Laboratory tasks and its implementation are described below. This thesis also contains a detailed lab instructions and reference values.
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Correlation analysis of optically trapped particle motion
Koudelníček, Karel ; Jákl,, Petr (referee) ; Harabiš, Vratislav (advisor)
This bachelor’s thesis deals with the description of random (Brownian) motion of microscopic particle trapped by optical trap. This thesis provides overview of possible usage in biology. The major part of the thesis is dedicated to description of methods that allow characterize optical trap with etc. stiffness thanks to the random motion. First, the estimation methods are tested on the simulated data. Before using these methods for real data, it was necessary to modify them, specifically to eliminate crosstalk and frequency noise. The differences in the estimation of the stiffness from the autocorrelation function and the power spectrum were described in the conclusion.
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A laboratory task to verify the properties of audio devices
Staňková, Karolína ; Marcoň, Petr (referee) ; Mikulka, Jan (advisor)
The aim of this thesis is familiarization with the parameters of an audio device and their measurements according to the standards (AES17-2018 and ČSN EN 60268-3). A laboratory task for the Measurement in Audio Engineering course is designed, based on the study of the standards. The first part of the thesis deals with detailed analysis of the measurements of different parameters of audio device. The described procedures are consequently employed to design the laboratory task. The second part of this thesis is dedicated to design the laboratory task. The automatized system based on HP VEE platform was developed to provide the multiple measurement. The attachments of this thesis contain the student’s manual for the laboratory task, the sample protocol, the testing measurement manual and the sample protocol for the testing measurement.
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Analysis of information leakage from optical transmission system
Šimon, Václav ; Horváth, Tomáš (referee) ; Münster, Petr (advisor)
This bachelor thesis deals with the structure of an optical transmission system. It focuses mainly on the transmission part of the system. It describes its parts and the functioning of the components used. It also deals with the risks of information leakage at various levels of the system (backbone networks, distribution and access networks, optical fiber). The practical part examines the issue of 3 possible risks. Firstly is measured the effect of unauthorized connection of a splitter to the optical path, then the eavesdropping in dense wavelength division multiplexing networks and the last measurement deals with the eavesdropping of the upstream signal in GPON access networks.
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Wingless/Notch crosstalk in Drosophila melanogaster
Hajšmanová, Hana ; Mašek, Jan (advisor) ; Macůrková, Marie (referee)
Fundamental for the existence of multicellular organisms is the presence signalling pathways, complex biochemical cascades, allowing reciprocal communication amongst the cells. Both Notch and Wnt pathways are crucial for embryonic development and their deregulation leads to many severe diseases. Decades of research, largely based on model organism D. melanogaster, showed that components of these pathways do not function strictly separately but on contrary interact with each other (crosstalk). This phenomenon is explored only to a lesser extent in mammals. The aim of this thesis is to recapitulate existing findings of Wnt/ Notch crosstalk in D. melanogaster and outline where crosstalk could play a role in mammals.
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Verification Of Transmission Parameters Of Multicore Optical Fiber
Látal, Michal
With the ever-increasing demands on the transmission parameters of telecommunicationoptical systems, such as transmission capacity, new challenges arise for scientists to meet these requirements.One of the possible solutions to increase the transmission capacity of telecommunicationnetworks is the multicore optical fiber, which is the current trend in modern space division multiplex.First and second chapters of the article deal with the modern concept of space division multiplex.A selected seven-core optical fiber was tested for insertion loss, attenuation, length for individualcores, and fiber continuity using the direct and backscattering method. The achieved results of theperformed measurements are summarized and commented in the third chapter of the article.
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