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Screening of biological activity of various species of the family Amaryllidaceae
Němečková, Kateřina ; Šafratová, Marcela (advisor) ; Vrabec, Rudolf (referee)
Němečková, K.: Screening of biological activity of various species of the family Amaryllidaceae. Diploma thesis, Charles University, Pharmaceutical Faculty in Hradec Králové, Department of pharmacognosy and pharmaceutical botany, Hradec Králové 2024, 70 p. Key words: Amaryllidaceae, bulbs, alkaloidal extracts, GC/MS analysis, biological activity, acetylcholinesterase, butyrylcholinesterase. The family Amaryllidaceae is irreplaceable in the natural kingdom. In folk medicine it is used to deal with simple ailments such as colds and infections. The plant species of this family are abundant in nature, the core of the action are secondary metabolites. The most important metabolites are Amaryllidaceae alkaloids, which can be categorized into groups according to their basic structure. Majority of alkaloids belonging to the Amaryllidaceae family have similar effects and are therefore intensively studied, the most promising representatives have anticancer, antibacterial, antifungal, antiviral and antimalarial activity. The abilities of alkaloids to inhibit human cholinesterases, which may have neuroprotective effects especially on cognitive decline, have also been analyzed. Assessing the biological activity and revealing the presence of new alkaloids in selected plants was the aim of this thesis. The...
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Screening of biological activity of various species of the genus Kalanchoe
Mai, Thanh Tam ; Šafratová, Marcela (advisor) ; Hošťálková, Anna (referee)
Mai T. T.: Screening of biological activity of various species of the genus Kalanchoe, Diploma thesis, Charles University, Faculty of Pharmacy in Hradec Králové, Department of Pharmacognosy and Pharmaceutical botany, Hradec Králové 2023. The content of this diploma thesis was the screening of the biological activity of dried flowers, stems and roots of four species from plants of the genus Kalanchoe: Kalanchoe delagoensis Eckl. & Zeyh., Kalanchoe fedschenkoi Raym.-Hamet & H.Perrier, Kalanchoe blossfeldiana Poelln. and Kalanchoe manginii 'Wendy' Raym.-Hamet & H.Perrier. By boiling the dried parts of the plants with ethanol, the summary ethanolic extracts were obtained, which were subjected to control TLC to detect the presence of alkaloids using Dragendorff's reagent. The presence of alkaloids was confirmed in the species Kalanchoe blossfeldiana Poelln, Kalanchoe manginii 'Wendy' Raym.-Hamet & H.Perrier and Kalanchoe delagoensis Eckl. & Zeyh. Furthermore, they were subjected to evidence reactions to identify the substances contained on TLC. In comparison with the literature, the presence of flavonoids, steroids substances, coumarins, triterpenes and alkaloids was confirmed in most plant extracts. Plants extracts of Kalanchoe blossfeldiana Poelln (AL-756 - extract from flowers and stems) and...
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