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Synchronization of peripheral circadian clocks during ontogenesis.
Paušlyová, Lucia ; Sumová, Alena (advisor) ; Hock, Miroslav (referee)
The circadian system is an important coordinator of physiological functions of a mammalian organism. It comprises of a central oscillator represented by cells in the suprachiasmatic nuclei of hypothalamus (SCN) and peripheral oscillators in most if not all cells of peripheral tissues. The peripheral oscillators, similarly to the central ones, generate circadian oscillations at the level of so called clock genes and their protein products. In peripheral tissues, oscillations in expression of the individual clock genes are autonomous, however, they need to be synchronized to ensure their robust rhythmic expression. The peripheral clocks are synchronized mainly by rhythmical signals from the SCN, including signals regulating food intake. Disturbances in the clock gene expressions, as well as impaired synchronization signals, can result in various pathophysiological states. Spontaneously hypertensive rat (SHR) strain is a convenient animal model to study potential connection between the disturbed circadian system and progressive development of hypertension and metabolical diseases in mammals. Various studies have shown differences in the rhythmical expression of clock genes between SHR strain and normotensive Wistar/Wistar-Kyoto strain. The aim of this thesis is to provide insight into the early...
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Algorithm for synchronization of radar air situation
Vilušínský, Zdeněk ; Kolovratník, David (advisor) ; Týnovský, Miroslav (referee)
The subject of this work is analysis and creation of an algorithm which would be able to find, based on input data from reference and measured radar air situation, a transformation od measured situation towards reference and finally valuate its usefulnes in practice. Program input is a file with measured data from both air situations. This work includes several examples of input date, which were used for testing purposes of algorithm. Output are values of several errors that manifests in examined situation.
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Suprachiasmatic nuclei as a daily clock and calendar
Pačesová, Dominika ; Sumová, Alena (advisor) ; Hock, Miroslav (referee)
The suprachiasmatic nuclei (SCN) harbor the master circadian pacemaker in mammals which is responsible for control and coordination of circadian rhythms throughout the body. They are a paired structure in the hypothalamus, located just above the optic chiasm, consisting of approximately 20 000 neurons. Due to their specific properties, the SCN have a unique position within the circadian system. They are connected with retina and, therefore, they can directly receive information about changes in external light/dark cycle. The individual SCN neurons are independent autonomous circadian oscillators which are inter-connected in a communication network. This network allows the individual SCN oscillators to synchronize among each other and thus to increase the precision and robustness of the oscillations. This work is focused to summarize the knowledge on the structure and function of the SCN at the level of single cells, subpopulations of cells and the whole SCN. The specific goal of this work is a summary of the factors that determine their central role within the circadian system.
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Movement in mathematics
Muchová, Zuzana ; Jirotková, Darina (advisor) ; Hejný, Milan (referee)
In my thesis I concern with the use of motoric activities in math classes. The chapters that offer a range of motoric activities were processed on the base of a questionnaire and an experiment. Some of the activities are currently being implemented in math classes by teachers of first, second and third grades at primary schools, others are part of textbooks designed for this age group. In addition to that, I offer five more possible activities, which have been recorded and interpreted within six experiments. The goal of the thesis is to demonstrate that physical movement cannot be separated from the life of six to nine years old children, and offer some motoric activities, which can potentially be contributive for development of mathematical skills and abilities.
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Cellular signaling pathways engaged in the entrainment of mammalian biological clock
Červená, Kateřina ; Bendová, Zdeňka (advisor) ; Svobodová, Irena (referee)
The mammalian biological clock is based on endogenous rhythmic oscillations of the so-called clock genes which affects the timing of the external manifestations, such as rhythmic alternations of sleep and activity. This endogenous mechanism, of which the innate period slightly deviates from the solar time, can be adjusted by various external synchronizers to the exact 24 hour period. This thesis is focused on the influence of the most prominent synchronizer, the sunlight, on the molecular basis of changes in the dynamics of internal mechanism of the oscillations in the main mammalian circadian pacemaker, the suprachiasmatic nuclei of the hypothalamus. There are numerous studies which have demonstrated the effect of various cellular signaling pathways on changes of circadian rhythms. The most common methods of assessing the oscillation phase changes, however, measure changes in output rhythms that may not always reflect the changes in the molecular mechanism itself. The aim is to evaluate which components of signaling pathways have provably shown to affect the dynamics of the rhythmic expression of clock genes.
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Communication of USB3.0 Chip with FPGA
Špeťko, Matej ; Viktorin, Jan (referee) ; Košař, Vlastimil (advisor)
SEC6NET is an abbreviation for project Modern tools for detection and mitigation of cyber criminality on the New Generation Internet. Project is focused on research and development of means for monitoring and analysing the network flow. Probes for monitoring IPv6 networks are developed within this project. Probes are using hardware acceleration based on FPGA platform. My thesis connects two technologies: FPGA and USB. The goal is to transfer data from the FPGA microchip to PC using Cypress EZ-USB FX3 microcontroller. The first part is focused on transferring data from FPGA to FX3 microcontroller. Second part describes the modification of FX3 firmware for getting maximum throughput. The last part focuses on implementing PC application for Linux operating system. The application receives data from the probe and saves them into hard drive using PCAP format.
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Synchronization of DNS Records between LDAP Database and DNS Server
Bašti, Martin ; Matoušek, Petr (referee) ; Čejka, Rudolf (advisor)
Cílem této práce je prozkoumat možnosti uložení DNS dat v LDAP databázi a jejich oboustranné synchronizace s DNS serverem s využitím standardních technologií, paralelizace a jednoduché rozšiřitelnosti o podporu různých DNS a LDAP serverů s různými DNS schématy. Práce dále popisuje různa schémata pro uložení dat v LDAP databázi a analyzuje problémy spojené se synchronizací a navrhuje jejich řešení. Výsledkem je prototyp synchronizační aplikace s doporučenými nastaveními pro DNS server a LDAP databázi, která je schopna efektivně synchronizovat DNS data.
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Synchronous Formal Systems Based on Grammars and Transducers
Horáček, Petr ; Janoušek, Jan (referee) ; Yamamura,, Akihito (referee) ; Meduna, Alexandr (advisor)
Tato disertační práce studuje synchronní formální systémy založené na gramatikách a převodnících a zkoumá jak jejich teoretické vlastnosti, tak i perspektivy praktických aplikací. Práce představuje nové koncepty a definice vycházející ze známých principů řízeného přepisování a synchronizace. Navrhuje alternativní způsob synchronizace bezkontextových gramatik, založený na propojení pravidel. Tento princip rozšiřuje také na řízené gramatiky, konkrétně gramatiky s rozptýleným kontextem a maticové gramatiky. Dále je představen na podobném principu založený nový druh převodníku, tzv. pravidlově omezený převodník. Jedná se o systém složený z konečného automatu a bezkontextové gramatiky. Práce prezentuje nové teoretické výsledky ohledně generativní a přijímajicí síly. Poslední část práce zkoumá možnosti lingvisticky orientovaných aplikací se zameřením na překlad přirozeného jazyka. Diskutuje a srovnává hlavní výhody nových modelů s využitím vybraných případových studií z českého, anglického a japonského jazyka pro ilustraci.
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The use of user accounts and related server services among primary schools
NOVOTNÝ, Jakub
The content of the bachelor's thesis is the way how user accounts are used by pupils and staff at primary schools, whether the school uses a server, alternatively which services are running there and how they are configured, and whether it is used only local accounts, or at least partially synchronized. The thesis is also concerned with the solution which is set at a particular primary school, which reason led to that, and whether it is suitable for its needs (the pros and cons of the solution). All of the information was gathered via recorded interviews with ICT coordinators and network administrators of schools, and interviews were also accompanied by teacher's view. The result of this work is the finding that the use of user accounts, servers and related server services at schools brings huge asset to not only teachers and students, but also to an administrator of the school network. This is due to the portability of user data, simplification and centralized administration of the school network. This work can therefore help schools in making decision whether establish user accounts for their employees and pupils, and possibly administrators with creating user accounts.
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Wi-Fi enabled sensor node
Usnul, Jan ; Gutman, Jiří (referee) ; Hynčica, Ondřej (advisor)
This work evaluates uses of standard IEEE 802.11 in automatization industry specifically in measurement industry. This work measures and evaluates chip CC3200 from Texas Instrument company, which include processor Cortex M-4 from ARM company and network procesor CC3100 from Texas Instrument company integrated in one chip.
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