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	Syntéza (purin-6-yl)aminokyselin Čapek, Petr ; Hocek, Michal New (purin-6-yl)amino acids were prepared by cross-coupling reactions. Detailed record
	Syntézy a transformace 6-(hydroxymethyl)purinů Šilhár, Peter ; Pohl, Radek ; Votruba, Ivan ; Hocek, Michal 6-(Hydroxymethyl)purines were prepared by cross-coupling reactions of ž-halopurines with acyloxymethylzinc and were subsequently transformed to 6-(fluoromethyl)purines. Detailed record
	Syntéza purinů nesoucích funkcionalizované C-substituenty nukleofilními adicemi na 6-ethynyl- and 6-vinylpuriny Kuchař, Martin ; Hocek, Michal Conjugate of nucleophiles additions to 6-ethynyl- and 6-vinylpurines were studied. Detailed record
	Syntéza C-arylribosidů katalytickými [2+2+2]-cyklotrimerizacemi Novák, P. ; Hocek, Michal ; Kotora, Martin C-aryldeoxyribosides were prepared by catalytic [2+2+2]-cyclotrimerization of deoxyribofuranosylacetylene with diynes. Detailed record
	Acyklické nukleosidfosfonáty obsahující O-substituované hydroxypyridinaminy a diaminy jako nukleobase Otmar, Miroslav ; Masojídková, Milena ; Holý, Antonín Congeners of the PMEO class of acyclic nucleoside phosphonates containing pyridine instead of pyrimidine ring were synthesized. Detailed record
	Syntéza nových racemických konformačně omezených karbocyklických nukleosidů Šála, Michal ; Hřebabecký, Hubert ; Masojídková, Milena ; Holý, Antonín Novel racemic conformationally locked nucleosides, derived from bicyclo[2.2.1]heptene or heptane, were prepared and tested for their biological activity. Detailed record
	Acyklické bis-fosfonátové nukleosidy - nová analoga ANP Vrbovská, Silvie ; Holý, Antonín As a part of the systematic SAR study in ANP series (many of ANP derivatives posses significant antiviral and cytostatic activity), we intended to study the behavior of ANP analogues bearing in the molecule two phosphonate residues. Detailed record
	Tricyklické etheno analogy purinů odvozené od 2-amino-6-chlorpurinu Hořejší, Kateřina ; Pohl, Radek ; Holý, Antonín A series of new linear and angular tricyclic etheno-bridged derivatives was synthesized from 2-amino-6-chloropurine and regioselectivity of the cyclization reaction was studied. Detailed record
	Syntéza a vlastnosti chirálních acyklických nukleosid bisfosfonátů s otevřeným kruhem Doláková, Petra ; Masojídková, Milena ; Holý, Antonín A new type of acyclic nucleoside phosphonates (ANP) is derived from 2,4-diamino-6-hydroxypyrimidine. These 6-[2-(phosphonomethoxy)ethoxy]pyrimidine derivatives significantly inhibit replication of retroviruses and herpesviruses in cell cultures. This novel subclass of pyrimidine ANPs can be considered as analogues of 2,6-diaminopurine with an open imidazole ring in the purine moiety. Detailed record
	Syntéza N4-substituovaných derivátů 1-[(S)-3-hydroxy-2-(phosphonomethoxy)propyl]cytosinu (HPMPC, Cidofovir, Vistide) Chalupová, Šárka ; Holý, Antonín 1-[(S)-3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (HPMPC, Cidofovir) has a broad activity spectrum against DNA viruses. As the systemic drug VireadTM is used for treatment of cytomegalovirus retinitis in AIDS patients. Based on this unique profile of HPMPC we have investigated the effect of the substitution of the amino function at the position 4 upon the antiviral activity. Detailed record

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