National Repository of Grey Literature 45 records found  beginprevious36 - 45  jump to record: Search took 0.03 seconds. 
Syntéza (purin-6-yl)aminokyselin
Čapek, Petr ; Hocek, Michal
New (purin-6-yl)amino acids were prepared by cross-coupling reactions.
Syntézy a transformace 6-(hydroxymethyl)purinů
Šilhár, Peter ; Pohl, Radek ; Votruba, Ivan ; Hocek, Michal
6-(Hydroxymethyl)purines were prepared by cross-coupling reactions of ž-halopurines with acyloxymethylzinc and were subsequently transformed to 6-(fluoromethyl)purines.
Syntéza C-arylribosidů katalytickými [2+2+2]-cyklotrimerizacemi
Novák, P. ; Hocek, Michal ; Kotora, Martin
C-aryldeoxyribosides were prepared by catalytic [2+2+2]-cyclotrimerization of deoxyribofuranosylacetylene with diynes.
Acyklické nukleosidfosfonáty obsahující O-substituované hydroxypyridinaminy a diaminy jako nukleobase
Otmar, Miroslav ; Masojídková, Milena ; Holý, Antonín
Congeners of the PMEO class of acyclic nucleoside phosphonates containing pyridine instead of pyrimidine ring were synthesized.
Syntéza nových racemických konformačně omezených karbocyklických nukleosidů
Šála, Michal ; Hřebabecký, Hubert ; Masojídková, Milena ; Holý, Antonín
Novel racemic conformationally locked nucleosides, derived from bicyclo[2.2.1]heptene or heptane, were prepared and tested for their biological activity.
Acyklické bis-fosfonátové nukleosidy - nová analoga ANP
Vrbovská, Silvie ; Holý, Antonín
As a part of the systematic SAR study in ANP series (many of ANP derivatives posses significant antiviral and cytostatic activity), we intended to study the behavior of ANP analogues bearing in the molecule two phosphonate residues.
Tricyklické etheno analogy purinů odvozené od 2-amino-6-chlorpurinu
Hořejší, Kateřina ; Pohl, Radek ; Holý, Antonín
A series of new linear and angular tricyclic etheno-bridged derivatives was synthesized from 2-amino-6-chloropurine and regioselectivity of the cyclization reaction was studied.
Syntéza a vlastnosti chirálních acyklických nukleosid bisfosfonátů s otevřeným kruhem
Doláková, Petra ; Masojídková, Milena ; Holý, Antonín
A new type of acyclic nucleoside phosphonates (ANP) is derived from 2,4-diamino-6-hydroxypyrimidine. These 6-[2-(phosphonomethoxy)ethoxy]pyrimidine derivatives significantly inhibit replication of retroviruses and herpesviruses in cell cultures. This novel subclass of pyrimidine ANPs can be considered as analogues of 2,6-diaminopurine with an open imidazole ring in the purine moiety.
Syntéza N4-substituovaných derivátů 1-[(S)-3-hydroxy-2-(phosphonomethoxy)propyl]cytosinu (HPMPC, Cidofovir, Vistide)
Chalupová, Šárka ; Holý, Antonín
1-[(S)-3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (HPMPC, Cidofovir) has a broad activity spectrum against DNA viruses. As the systemic drug VireadTM is used for treatment of cytomegalovirus retinitis in AIDS patients. Based on this unique profile of HPMPC we have investigated the effect of the substitution of the amino function at the position 4 upon the antiviral activity.

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