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Xanthone derivatives with potential dual mode of action for Alzheimer Disease
Suchánková, Barbora ; Štaud, František (advisor) ; Trejtnar, František (referee)
It is known that the malfunctions of different, but interconnected, biochemical complex pathways are related to Alzheimer Disease (AD) and play an important role in the pathogenesis of the disease. This neurodegenerative disease is caused by genetic, environmental, and endogenous factors, but exact pathogenesis is not fully known yet. It's a multifactorial disease including protein misfolding and aggregation, oxidative stress and free radical formation, metal dyshomeostasis, mitochondrial dysfunction, and phosphorylation impairment, all occurring concurrently. Inhibition of acetylcholinesterase (AChE) and therefore prevention of acetylcholine degradation is one of the most accepted therapy opportunities for AD. Another approach is consistent with the production of reactive oxygen species (ROS) that occurs in the aging brain because of a decline in antioxidant defense mechanisms. ROS can attack proteins and membrane lipids causing progressive neurodegeneration. Therefore drugs that can either reduce the formation of ROS and/or protect cells from their damaging effects may decrease neurodegeneration and slow its progression. Considering these, the effect of several synthetic xanthone derivatives on AChE activity has been evaluated. Additionally, the antioxidant activity and metal chelating activity...
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Xanthone derivatives with potential dual mode of action for Alzheimer Disease
Suchánková, Barbora ; Štaud, František (advisor) ; Trejtnar, František (referee)
It is known that the malfunctions of different, but interconnected, biochemical complex pathways are related to Alzheimer Disease (AD) and play an important role in the pathogenesis of the disease. This neurodegenerative disease is caused by genetic, environmental, and endogenous factors, but exact pathogenesis is not fully known yet. It's a multifactorial disease including protein misfolding and aggregation, oxidative stress and free radical formation, metal dyshomeostasis, mitochondrial dysfunction, and phosphorylation impairment, all occurring concurrently. Inhibition of acetylcholinesterase (AChE) and therefore prevention of acetylcholine degradation is one of the most accepted therapy opportunities for AD. Another approach is consistent with the production of reactive oxygen species (ROS) that occurs in the aging brain because of a decline in antioxidant defense mechanisms. ROS can attack proteins and membrane lipids causing progressive neurodegeneration. Therefore drugs that can either reduce the formation of ROS and/or protect cells from their damaging effects may decrease neurodegeneration and slow its progression. Considering these, the effect of several synthetic xanthone derivatives on AChE activity has been evaluated. Additionally, the antioxidant activity and metal chelating activity...
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Teorie devizových kurzů a prognózování
Suchánková, Barbora ; Pígl, Jan (advisor)
Tato práce se zabývá tématikou devizových kurzů. V teoretické části definice devizového kurzu, jeho základní charakteristiky, a vývoj devizového kurzu. Následují základní teorie pro predikci devizového kurzu v dlouhodobém období, fundamentální analýza: teorie parity kupní síly, teorie parity úrokové míry, mezinárodní Fischerův efekt a teorie platební bilance. Dále je fundamentální analýza pro predikci kurzu v krátkém období, která se zaměřuje na grafické metody pro zkoumání vývoje kurzu, a matematicko-statistické metody. Analytická část práce ověřuje závěry teorie parity kupní síly, teorie parity úrokové míry a metodu klouzavého průměru na vývoji CZK/GBP.
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