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E-commerce Expansion Management
Sojka, David ; Pfeifer, Marcel Rolf (referee) ; Putnová, Anna (advisor)
This master thesis pursues a business model of an online store's international expansion in Europe. According to theoretical backgrounds, it evaluates the state of currently used methods of today's expansion strategy. Further, a management plan for systematic expansion is being proposed along with risk mitigations, stabilization of current international operations, and a proposal of a technological-information solution for data science.
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Innovation of the Fashion e-Commerce
Sojka, David ; Ing.Vít Hanák (referee) ; Putnová, Anna (advisor)
This bachelor thesis deals with economic problematics of fashion e-commerce. According to the theoretical backgrounds, it evaluates the analysis of the current state-of-art including currently used mitigation methods. Further, a solution is being proposed for the reduction of the economic and ecological impact on sustainable development of this business activity. The result of this thesis is a comprehensive, quality and feasible innovation proposal, which will be based on adequate methods for its realization.
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Calcium homeostasis and modulation of nociceptive synaptic transmission
Sojka, David ; Paleček, Jiří (advisor) ; Žurmanová, Jitka (referee) ; Krůšek, Jan (referee)
2 SUMMARY OF THE THESIS This study was designed to improve our knowledge regarding mechanisms of nociceptive signaling at spinal cord level. One of the forms of spinal cord synaptic transmission modulation is central sensitization, a manifestation of synaptic plasticity at spinal cord level, which was found to be present at many chronic pain syndromes. This study deals mainly with a development of calcium imaging technique with a final goal to study mechanisms of central sensitization in vitro on population of dorsal horn neurons. We have analyzed synaptically evoked intracellular Ca changes as a result of dorsal root stimulation in a superficial dorsal horn area in spinal cord slices and found two types of Ca responses: one synchronized with electrical stimulation and a second one, delayed response due to Ca release from internal stores. The delayed Ca release was not previously shown to be present in these neurons and it was not dependent on activation of ionotropic glutamatergic receptors, suggesting involvement of metabotropic receptor pathway. The presence of this delayed type of Ca response could have a significant role in the induction of some types of chronic pain syndromes since intracellular calcium increase is thought to be a key trigger point in spinal cord neurons sensitization. An important...
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E-commerce Expansion Management
Sojka, David ; Pfeifer, Marcel Rolf (referee) ; Putnová, Anna (advisor)
This master thesis pursues a business model of an online store's international expansion in Europe. According to theoretical backgrounds, it evaluates the state of currently used methods of today's expansion strategy. Further, a management plan for systematic expansion is being proposed along with risk mitigations, stabilization of current international operations, and a proposal of a technological-information solution for data science.
|
|
|
Calcium homeostasis and modulation of nociceptive synaptic transmission
Sojka, David
This study was designed to improve our knowledge regarding mechanisms of nociceptive signaling at spinal cord level. One of the forms of spinal cord synaptic transmission modulation is central sensitization, a manifestation of synaptic plasticity at spinal cord level, which was found to be present at many chronic pain syndromes. This study deals mainly with a development of calcium imaging technique with a final goal to study mechanisms of central sensitization in vitro on population of dorsal horn neurons. We have analyzed synaptically evoked intracellular Ca changes as a result of dorsal root stimulation in a superficial dorsal horn area in spinal cord slices and found two types of Ca responses: one synchronized with electrical stimulation and a second one, delayed response due to Ca release from internal stores. The delayed Ca release was not previously shown to be present in these neurons and it was not dependent on activation of ionotropic glutamatergic receptors, suggesting involvement of metabotropic receptor pathway. The presence of this delayed type of Ca response could have a significant role in the induction of some types of chronic pain syndromes, since intracellular calcium increase is thought to be a key trigger point in spinal cord neurons sensitization. An important role in neuronal calcium...
|
|
|
Innovation of the Fashion e-Commerce
Sojka, David ; Ing.Vít Hanák (referee) ; Putnová, Anna (advisor)
This bachelor thesis deals with economic problematics of fashion e-commerce. According to the theoretical backgrounds, it evaluates the analysis of the current state-of-art including currently used mitigation methods. Further, a solution is being proposed for the reduction of the economic and ecological impact on sustainable development of this business activity. The result of this thesis is a comprehensive, quality and feasible innovation proposal, which will be based on adequate methods for its realization.
|
|
|
Calcium homeostasis and modulation of nociceptive synaptic transmission
Sojka, David
This study was designed to improve our knowledge regarding mechanisms of nociceptive signaling at spinal cord level. One of the forms of spinal cord synaptic transmission modulation is central sensitization, a manifestation of synaptic plasticity at spinal cord level, which was found to be present at many chronic pain syndromes. This study deals mainly with a development of calcium imaging technique with a final goal to study mechanisms of central sensitization in vitro on population of dorsal horn neurons. We have analyzed synaptically evoked intracellular Ca changes as a result of dorsal root stimulation in a superficial dorsal horn area in spinal cord slices and found two types of Ca responses: one synchronized with electrical stimulation and a second one, delayed response due to Ca release from internal stores. The delayed Ca release was not previously shown to be present in these neurons and it was not dependent on activation of ionotropic glutamatergic receptors, suggesting involvement of metabotropic receptor pathway. The presence of this delayed type of Ca response could have a significant role in the induction of some types of chronic pain syndromes, since intracellular calcium increase is thought to be a key trigger point in spinal cord neurons sensitization. An important role in neuronal calcium...
|
|
|
Calcium homeostasis and modulation of nociceptive synaptic transmission
Sojka, David ; Paleček, Jiří (advisor) ; Žurmanová, Jitka (referee) ; Krůšek, Jan (referee)
2 SUMMARY OF THE THESIS This study was designed to improve our knowledge regarding mechanisms of nociceptive signaling at spinal cord level. One of the forms of spinal cord synaptic transmission modulation is central sensitization, a manifestation of synaptic plasticity at spinal cord level, which was found to be present at many chronic pain syndromes. This study deals mainly with a development of calcium imaging technique with a final goal to study mechanisms of central sensitization in vitro on population of dorsal horn neurons. We have analyzed synaptically evoked intracellular Ca changes as a result of dorsal root stimulation in a superficial dorsal horn area in spinal cord slices and found two types of Ca responses: one synchronized with electrical stimulation and a second one, delayed response due to Ca release from internal stores. The delayed Ca release was not previously shown to be present in these neurons and it was not dependent on activation of ionotropic glutamatergic receptors, suggesting involvement of metabotropic receptor pathway. The presence of this delayed type of Ca response could have a significant role in the induction of some types of chronic pain syndromes since intracellular calcium increase is thought to be a key trigger point in spinal cord neurons sensitization. An important...
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