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Influence of TNF-α on hENaC subunits expression
Martan, David ; Svobodová, Hana (advisor) ; Matoušková, Petra (referee)
University of Vienna Faculty of Life Sciences Department of Pharmacology and Toxicology Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Biochemical Sciences Candidate: David Martan Supervisors: Prof. Dr. Rosa Lemmens-Gruber, PharmDr. Hana Bártíková, Ph.D. Title of the diploma thesis: Influence of TNF-α on hENaC subunits expression The human amiloride-sensitive epithelial sodium channel (hENaC) is a type of ion channel which has the ability to control salt and water homeostasis. Therefore it is one of the main driving forces for the reabsorption of water through the alveolar epithelium. A dysfunction of this channel, respectively of this control mechanism, leads to a very severe disease - pulmonary edema and several other pathological conditions. Previous studies tested a drug called AP301, recently named solnatide. AP301 is a cyclic protein comprising the human tumour necrosis factor lectin-like domain sequence. This drug was recently developed as a potential treatment of pulmonary edema. The principle is that it activates hENaC by increasing the open probability. It was also shown that AP301 transiently increases the expression of hENaC subunits in mammalian cells. In this study we used the Western blot method to test the influence of tumour necrosis factor α...
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Influence of TNF-α on hENaC subunits expression
Martan, David ; Svobodová, Hana (advisor) ; Matoušková, Petra (referee)
University of Vienna Faculty of Life Sciences Department of Pharmacology and Toxicology Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Biochemical Sciences Candidate: David Martan Supervisors: Prof. Dr. Rosa Lemmens-Gruber, PharmDr. Hana Bártíková, Ph.D. Title of the diploma thesis: Influence of TNF-α on hENaC subunits expression The human amiloride-sensitive epithelial sodium channel (hENaC) is a type of ion channel which has the ability to control salt and water homeostasis. Therefore it is one of the main driving forces for the reabsorption of water through the alveolar epithelium. A dysfunction of this channel, respectively of this control mechanism, leads to a very severe disease - pulmonary edema and several other pathological conditions. Previous studies tested a drug called AP301, recently named solnatide. AP301 is a cyclic protein comprising the human tumour necrosis factor lectin-like domain sequence. This drug was recently developed as a potential treatment of pulmonary edema. The principle is that it activates hENaC by increasing the open probability. It was also shown that AP301 transiently increases the expression of hENaC subunits in mammalian cells. In this study we used the Western blot method to test the influence of tumour necrosis factor α...
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Influence of TNF-α on hENaC subunits expression
Martan, David ; Svobodová, Hana (advisor) ; Matoušková, Petra (referee)
University of Vienna Faculty of Life Sciences Department of Pharmacology and Toxicology Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Biochemical Sciences Candidate: David Martan Supervisors: Prof. Dr. Rosa Lemmens-Gruber, PharmDr. Hana Bártíková, Ph.D. Title of the diploma thesis: Influence of TNF-α on hENaC subunits expression The human amiloride-sensitive epithelial sodium channel (hENaC) is a type of ion channel which has the ability to control salt and water homeostasis. Therefore it is one of the main driving forces for the reabsorption of water through the alveolar epithelium. A dysfunction of this channel, respectively of this control mechanism, leads to a very severe disease - pulmonary edema and several other pathological conditions. Previous studies tested a drug called AP301, recently named solnatide. AP301 is a cyclic protein comprising the human tumour necrosis factor lectin-like domain sequence. This drug was recently developed as a potential treatment of pulmonary edema. The principle is that it activates hENaC by increasing the open probability. It was also shown that AP301 transiently increases the expression of hENaC subunits in mammalian cells. In this study we used the Western blot method to test the influence of tumour necrosis factor α...
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New trends in the automotive industry
Martan, David ; Smrčka, Luboš (advisor) ; Zámečník, Petr (referee)
This thesis describes new trends in the automotive industry. It investigates how these trends altered the automotive market and industry and what are the reasons of it. The thesis then ascertains an impact on the new cars business, in which stress is put on new technologies and automotive market development in the world, with emphasis on the Czech Republic within the crisis period. The thesis follows 2 trend groups, namely the trends that already appear for a longer time as well as the quite new trends influencing substantially the automotive market. The first named group deals with the technological innovations as well as for example with the problem concerning car factories model families expanding with the aim to maximize volume of sale; problems of the car new models safety and performance is another topic of this thesis. As another important topic of this group diesel drive phenomenon problems in the European Union can be taken into account as well as additional burden of taxation for cars with higher fuel consumption connected with it. A significant part of the second group comprises financial crisis development and impact on the new cars sale in a given period. In addition to it, it describes quite new trends, e.g. engine capacity decreasing with the use of supercharged engines (downsizing), coming wave of SUV cars and a phenomenon of four-wheel drive cars. In the final part of this diploma paper problems are analyzed and finally hybrid cars development as well.
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Marketing in time of crisis
Martan, David ; Pešek, Ondřej (advisor) ; Škaloud, Petr (referee)
Without any overstatement it could be said that the American mortgage crisis influenced the whole world. It is in no way about some chosen ones but about a recession hitting more or less the whole society. In the times of recession companies and even the governments cut the costs which are not necessarily needed to run the business and they ignore the long-term perspective. In the 2008 the economical situation has changed a lot because of the risky trading of the mortgage packages on the OTC markets. The aim of this work is to find out if and how much the behavior of the companies from the marketing point of view will be affected.
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