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Immunophenotype differences in non-memory B lymphocyte populations in healthy controls and patients with immunopathologies
Polák, Milan ; Růžičková, Šárka (advisor) ; Šplíchal, Igor (referee)
B-lymphocytes are a subset of immune cells that can be distinguished mainly by carrying clonally diversified membrane-bound immunoglobulin specialized to specific antigen recognition. Together with other immunocytes B-lymphocytes play a central role in adaptive immune system which takes part in defense of the host against wide variety of pathogens. Recently the evidence has supported the emerging concept of different B-cell subpopulations to play a direct or indirect role in a pathogenesis of spectrum of disorders. However, so far the knowledge has been limited mainly in the way of how the specific differentiation stages of B-lymphocytes are involved in pathogenesis of diseases and how course of disease, stage, and eventually different treatment can affect B-cell homeostasis. That is the reason for the thesis to be focused on an analysis of B-cell population profile changes in disease, identification of any association present among specific B-cell subpopulations, as well as association between these subpopulations and clinical parameters. Using polychromatic flow cytometry we analyzed frequencies of 11 B-cell subpopulations including stages of transient B-lymphocytes through effector antibody-producing plasma cells. We examined 81 individuals including 22 healthy controls and 59 patients with...
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The role of A2A adenosine receptor in NK cell-mediated cytotoxicity
Kuldová, Markéta ; Svoboda, Jan ; Kovářů, H. ; Kovářů, F. ; Šplíchal, Igor ; Fišerová, Anna
Adenosine receptor, NK cell, immunity systém, cytotoxicity, Salmonella typhimurium, colorectal carcinoma, murine model, newborn pigs model
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