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Semisynthetic preparation of human insulin analogs containing .I.N./I.-methylated B.sup.24./sup.-B.sup.25./sup. or B.sup.25./sup.-B.sup.26./sup. peptide bonds
Klasová, L. ; Huml, Karel ; Barthová, J. ; Ubik, Karel ; Kašička, Václav ; Škarda, Josef ; Hauzerová, Linda ; Barth, Tomislav ; Wollmer, A. ; Brandenburg, D. ; Ježek, Jan ; Velek, Jiří
Desoctapeptideinsulin (DOI), prepared by tryptic cleavage of porcine insulin, was utilized in the enzyme-catalyzed synthesis of human insulin analogs modified in the C-terminal region of the B-chain.
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Preparation and characterization of analogs of tetrapeptide B 23 -B 26 and octapeptide B 23 -B 30 of human insulin
Ježek, Jan ; Velek, Jiří ; Velková, Vlasta ; Klasová, L. ; Barthová, J. ; Ubik, Karel ; Kašička, Václav ; Barth, Tomislav ; Wollmer, A. ; Huml, Karel ; Hauzerová, Linda ; Brandenburg, D.
Gly-Phe-Phe-PheNH2, Gly-Phe-Phe-N(Me)Phe-NH2, Gly-Phe-N(Me)Phe-Phe-NH2, and Gly-Phe-Phe-N(Me)Tyr-NH2 and octapeptides Gly-Phe-Phe-N(Me)Phe-Thr-Pro-Lys(Pac)-Thr-OH and Gly-Phe-Phe-Phe-Thr-Pro-Lys(Pac)-Thr-OH. The compounds were isolated by preparative HPLC and characterized by amino acid analysis.
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Factorizace 2-D polynom
Ježek, Jan ; Zezula, P.
Many algorithms are solving the problem of 1-D factorization. One of them was used and generalized to 2-D. This simple step brings new different difficulties up. Nevertheless, by no means could be the matter of 2-D factorization announced as completely investigated. Just a case with explicitly defined causality in both variables is offered in this paper. The numerical implementation of the algorithm below is the matter of ongoing labor.
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