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Analysis of antibiotic administration in prophylaxis I.
Domecký, Petr ; Malý, Josef (advisor) ; Matoulková, Petra (referee)
8 Abstract Analysis of antibiotic administration in prophylaxis I Author: Petr Domecký Tutor: PharmDr. Josef Malý, Ph.D. Consultant: PharmDr. Lucie Hauschke, Ph.D. Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Introduction and aims: Antibiotic prophylaxis (AP) plays an important role in reduction of surgical site infection (SSI). It is the administration of an eligible antibiotic or chemotherapeutic (ATB) in a single dose, usually 30 minutes before surgery, followed by two to three doses during or after the surgery, regarding the selected ATB and the surgical procedure. The aim of this work was to analyse the AP in surgical procedures at the Masaryk Hospital in Ústí nad Labem (MNUL) in the context of the MNUL guideline (DP) and the research on available AP work. Methods: A cross-sectional observational study ran from January 2018 to March 2018 in surgical departments at MNUL. The study included patients aged ≥ 18 years who underwent surgery in a defined period (5 February 2018 to 9 February 2018) and gave their consent to the study. The practicability of the study was verified by a pilot part. Initially, a research of published studies concerning AP was carried out which provided outputs for AP establishment (PPA). Subsequently, a form for...
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Attitudes towards treatment and knowledge of hormonal contraceptive users
Fufaľová, Veronika ; Malá, Kateřina (advisor) ; Matoulková, Petra (referee)
Diplomová práca Postoje k liečbe a znalosti užívateliek hormonálnej antikoncepcie Abstract Attitudes towards treatment and knowledge of hormonal contraceptive users Author: Veronika Fufaľová¹ Supervisor: PharmDr. Kateřina Ládová, Ph.D.¹ Consultant: PharmDr. Anna Oleárová, PhD., MPHš ¹Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University, Czech Republic šDepartment of Organisation and Management of Pharmacy, Faculty of Pharmacy, Comenius University in Bratislava, Slovak Republic Introduction: Hormonal contraception (HC) is popular and a reliable birth control method. Its use is although associated with some risks and many myths or misconceptions. Objective: The aim of this thesis was to determine the attitudes towards treatment and awareness of HC risks of its users in regard to various types and application forms in specific region by means of anonymous questionnaire. Methods: The research was carried out as a prospective questionnaire survey. Anonymous questionnaires consisted of 35 questions divided into 6 sections to obtain sociodemographic data, information concerning HC users and their form of HC, information about the extent of knowledge concerning gynaecological examination, HC risks and HC misconception awareness. One part of questionnaire was focused...
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The Importance of Self-Reported Medication Adherence in the Evaluation of the Effectiveness of Pharmacotherapy
Ládová, Kateřina ; Matoulková, Petra (advisor) ; Červený, Petr (referee) ; Lukáš, Milan (referee) ; Kolář, Jozef (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Social and Clinical Pharmacy Candidate: Mgr. Kateřina Ládová Supervisor: PharmDr. Petra Matoulková, Ph.D.; PharmDr. Magda Vytřísalová, Ph.D. (Consultant) Title of Doctoral Thesis: The Importance of Self-Reported Medication Adherence in the Evaluation of the Effectiveness of Pharmacotherapy Introduction and Objective: Medication adherence (MA) is a highly variable factor affecting the response to the therapy. Especially in chronic disease, non-adherence presents a problem that may have health, social, and even economic consequences. Measuring MA is the most often performed by self-reported surveys which enables, among others, their simple application in research as well as in every day clinical practices. Self-reported MA monitoring may contribute to maximizing the effectiveness of pharmacotherapy and minimizing the risk of therapy failure, however, standardization of measuring process is needed. Moreover, some factors such as healthy adherer effect (HAE), which reflect patient health seeking behaviour but cannot be easily monitored, can favourably affect health outcomes. Acquired results may then be incorrectly attributed to drug therapy examined in the study. Hence, the main aims of this doctoral thesis were: 1) to...
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The Importance of Self-Reported Medication Adherence in the Evaluation of the Effectiveness of Pharmacotherapy
Ládová, Kateřina ; Matoulková, Petra (advisor) ; Červený, Petr (referee) ; Lukáš, Milan (referee) ; Kolář, Jozef (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Social and Clinical Pharmacy Candidate: Mgr. Kateřina Ládová Supervisor: PharmDr. Petra Matoulková, Ph.D.; PharmDr. Magda Vytřísalová, Ph.D. (Consultant) Title of Doctoral Thesis: The Importance of Self-Reported Medication Adherence in the Evaluation of the Effectiveness of Pharmacotherapy Introduction and Objective: Medication adherence (MA) is a highly variable factor affecting the response to the therapy. Especially in chronic disease, non-adherence presents a problem that may have health, social, and even economic consequences. Measuring MA is the most often performed by self-reported surveys which enables, among others, their simple application in research as well as in every day clinical practices. Self-reported MA monitoring may contribute to maximizing the effectiveness of pharmacotherapy and minimizing the risk of therapy failure, however, standardization of measuring process is needed. Moreover, some factors such as healthy adherer effect (HAE), which reflect patient health seeking behaviour but cannot be easily monitored, can favourably affect health outcomes. Acquired results may then be incorrectly attributed to drug therapy examined in the study. Hence, the main aims of this doctoral thesis were: 1) to...
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Beliefs about medicines, Complementary and Alternative Medicine Use and Medication Adherence
Drapáková, Tereza ; Matoulková, Petra (advisor) ; Malý, Josef (referee)
1 ABSTRACT BELIEFS ABOUT MEDICINES, COMPLEMENTARY AND ALTERNATIVE MEDICINE USE AND MEDICATION ADHERENCE Student: Drapáková Tereza Tutor: PharmDr. Matoulková Petra, Ph.D. Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University in Prague, Czech Republic Introduction: Medication non-adherence is a very complex problem across different diseases leading to failure of treatment and increasing costs for medical care. Medication adherence is influenced by various factors and is also connected with different patients' attitudes to classical pharmacotherapy and complementary and alternative medicine (CAM). CAM is nowadays quite often used option for chronically treated patients. Aim of the study: The aim of the study was to analyse medication adherence at chronically treated patients visiting pharmacies in the Czech Republic, their attitudes to CAM including percentage of using CAM, the most common reasons using CAM and which types of CAM are the most spread among asked patients. Methods: Questionnaires were distributed in pharmacies in the Czech Republic among patients 18 years old and older who were chronically treated for at least 3 months. Selected patients were asked to complete a questionnaire containing questions about CAM, Czech version of Medication Adherence...
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Analysis of drug-related problems in a health facility I.
Bahnerová, Michaela ; Malý, Josef (advisor) ; Matoulková, Petra (referee)
Analysis of drug-related problems in a health facility I. Author: Michaela Bahnerová1 Tutor: Josef Malý1 1 Department of Social and Clinical Pharmacy, Charles University in Prague, Faculty of Pharmacy in Hradec Králové Intoduction: Drug-related problems (DRPs) lower the quality of health care and present a risk factor in patient's safety. Objectives: The aim of this thesis is identification, classification and further analysis of DRPs in health care facility. Methods: Revision of pharmacotherapy was performed in health care facility in term 6. 8. - 10. 8. 2012. The pharmaceutical team which contained two pharmacists and diplomant examined health documentation of patients hospitalized in the facility. We collected information from personal, allergic, family, and labor-social anamnesis of patients. This data were noted into electronical database and after revision were DRPs classified and evaluated. The results of DRPs identification were evaluated by frequency analysis. In ten randomly selected patients was described DRPs resolution. Results: In total we noticed medical therapy in 175 patients (61 % women). Average patient's age was 58 years. 482 DRPs were identified. Of the patients, 84 % had DRPs and an average of 2,75 DRPs were recorded per patient. Conclusion: Appearance of DRPs is very frequent and...
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Advertising on complementary, alternative medicines and over the counter medicines (OTC) published in the printed journals for lay people from the view of Evidence Based Medicine
Schirlová, Zuzana ; Matoulková, Petra (advisor) ; Malý, Josef (referee)
Advertising on complementary, alternative medicines and over the counter medicines (OTC) published in the printed journals for lay people from the view of Evidence Based Medicine Student: Schirlová. Z Tutor: Matoulková, P. Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University in Prague, Czech Republic INTRODUCTION: Advertisements are important means of communicating information to public. The quality of the pharmaceutical advertising has been continuously discused. METHODS: The objective of the study was to assess availability of supporting scientific information for health claims stated in the food supplements and OTC (Over-the- Counter) medicines ads that were published during period September 2012 and June 2013 in the mostly read life style journals for women. For each advertisement, the emphasized claim/-s was compared to available scientific unbiased evidence. The literature search was conducted by using Pubmed database (mainly meta-analysis and randomized clinical trials). Further information was searched in the Scholar Google, Natural Medicines Comprehensive Database (Consumer version) and Micromedex. Different keywords and their appropriate combinations were used to identify relevant information. Frequency analysis was used to assess frequency...
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Drug interactions of cardiovascular drugs and their analysis in the patients of community pharmacy
Vávrová, Zuzana ; Malý, Josef (advisor) ; Matoulková, Petra (referee)
Drug interactions of cardiovascular drugs and their analysis in the patients of community pharmacy Author: Zuzana Vávrová1 Tutor: PharmDr. Josef Malý, Ph.D.1 1 Department of Social and Clinical Pharmacy, Charles University in Prague, Faculty of Pharmacy in Hradec Králové Introduction: Drug interactions represent a serious health problem and they cause many hospitalizations. Although their identification and documentation received a considerable attention, they remain unrecognized for many patients. Objectives: The goal of the thesis was to analyze serious drug interactions between cardiovascular drugs, to describe their management in clinical practice, which is useful during dispensation, and to evaluate occurrence of these drug interaction in a community pharmacy. Methodology: The information was gained from several databases and compared, and afterwards management of major drug interactions of betablockers and calcium channel blockers was created. Patients of a community pharmacy were screened for these drug interactions. The data were processed by frequency analysis. Results: In the theoretical part, 94 drug interactions were analysed. The total number of patients who received betablockers or calcium channel blockers in the community pharmacy was 525. Serious drug interactions described in this...
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The analysis of eating habits of diabetics in the USA
Vaňkátová, Helena ; Vlček, Jiří (advisor) ; Matoulková, Petra (referee)
Besides the good drug compliance, appropriate nutrition plays important role in successful management of the metabolic aspects of type 2 diabetes mellitus (DM2), and in the prevention of diabetes-related conditions. The goal of this study was to analyze eating habits among DM2 patients in the United States. The Fat- and Fiber-Related Diet Habits Questionnaire (A.Shattuck, 1998) was used in this study to obtain identical data for comparison. The original version was slightly adjusted according to the local habits. The study took place at the El Rio Community Health Center clinics in Tucson, Arizona, USA; during the time period of three months (September to December 2011). Patients with DM2 patients visiting the clinic were recruited for participation. Once patients were given the questionnaire, answers were put into the database created in an Excel application (Microsoft Office 2010) and analyzed using the frequency analysis. 207 patients filled out the questionnaire. The mean age was 56,8 ± 12,6 years, the mean age when diagnosed with DM2 was 45,3 ± 12,7 years, BMI 33,2 ± 7,8 kg/m2, the mean waist circumference 109,7 ± 19,7 cm and the mean A1C was 8,1± 1,7% (ad DCCT). 10% of participants were treated only by the diet, 49% with peroral antidiabetics (PAD), 14% with insulin, and 28% with combination...
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The Pharmacotherapy of Chronic Non-maligant Pain Among Geriatric Patients
Bártová, Barbora ; Fialová, Daniela (advisor) ; Matoulková, Petra (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Social and Clinical Pharmacy Candidate: Mgr. Barbora Bartova Consultant: PharmDr. Daniela Fialova, PhD. Title of Thesis: The Pharmacotherapy of Chronic Non-malignant Pain among Geriatric Patients Introduction: Epidemiological studies demonstrate that prevalence of chronic pain increases with higher age. Furthermore, pain among older patients is often underrecognized and/or undertreated. Although rational treatment of geriatric pain has been extensively studied during the past decade, many older people still suffer from uncontrolled or insufficiently treated pain. The aim of this study is to evaluate the treatment of non-malignant chronic pain by general practitioners (GPs) in geriatric patients. Further, we discuss the role of pharmacist in rational pain pharmacotherapy as well as complex pharmacotherapy management in these patients. Methods: Data were obtained by prospective assessment of 80 geriatric patients 65+ (mean age 75,0 years (range 65-94 yrs), 80 % females) suffering from chronic nonmalignant pain. Evaluation of pain management and complex drug regimens was provided by specifically trained pharmacist in two general practices in Brno, Czech Republic (between March 2010 and December 2011). To assess the...
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