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The Importance of Self-Reported Medication Adherence in the Evaluation of the Effectiveness of Pharmacotherapy
Ládová, Kateřina ; Matoulková, Petra (advisor) ; Červený, Petr (referee) ; Lukáš, Milan (referee) ; Kolář, Jozef (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Social and Clinical Pharmacy Candidate: Mgr. Kateřina Ládová Supervisor: PharmDr. Petra Matoulková, Ph.D.; PharmDr. Magda Vytřísalová, Ph.D. (Consultant) Title of Doctoral Thesis: The Importance of Self-Reported Medication Adherence in the Evaluation of the Effectiveness of Pharmacotherapy Introduction and Objective: Medication adherence (MA) is a highly variable factor affecting the response to the therapy. Especially in chronic disease, non-adherence presents a problem that may have health, social, and even economic consequences. Measuring MA is the most often performed by self-reported surveys which enables, among others, their simple application in research as well as in every day clinical practices. Self-reported MA monitoring may contribute to maximizing the effectiveness of pharmacotherapy and minimizing the risk of therapy failure, however, standardization of measuring process is needed. Moreover, some factors such as healthy adherer effect (HAE), which reflect patient health seeking behaviour but cannot be easily monitored, can favourably affect health outcomes. Acquired results may then be incorrectly attributed to drug therapy examined in the study. Hence, the main aims of this doctoral thesis were: 1) to...
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Analysis of drug utilization of antibiotics for systematic administration in the Czech Republic in 2005-2019
Suchopárová, Lenka ; Malý, Josef (advisor) ; Kolář, Jozef (referee)
Analysis of drug utilization of antibiotics for systematic administration in the Czech Republic in 2005-2019 Author: Lenka Suchopárová Tutor: doc. PharmDr. Josef Malý, Ph.D. Consultant: Mgr. Petr Domecký Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles university Introduction and aims: Antibiotics (ATB) are substances with a bacteriostatic or bactericidal effect. Treatment with ATB carries a risk of side effects, drug interactions and risk of resistance occurence. The reason for monitoring the consumption of ATB is not only the apparent coherence between their consumption and the increase of resistance, but also the economic side of bacterial infections treatment. The aim of this study was to analyze the consumption of ATB for systematic administration in the Czech Republic (CR) in 2005-2019. Methods: The analysis of the consumption of ATB was performed as a retrospective analysis of data from the database of the State Institute of Drug Control in the period from 1. 1. 2005 to 31. 12. 2019. Anatomical-therapeutic-chemical classification based on defined daily doses (DDD) of individual drugs was used for the analysis. The consumption of ATB was calculated as DDD per thousand inhabitants per day (TID). The data on the number of residents was acquired from the...
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Selected Medicinal Products
Suchánek, David ; Kostřiba, Jan (advisor) ; Kolář, Jozef (referee)
Charles University, Faculty of Pharmacy in Hradec Kralove Department of Social and Clinical Pharmacy Student David Suchánek Supervisor PharmDr. Jan Kostřiba, Ph.D. Title of Diploma Thesis Selected medicinal products Introduction: According to market authorisation selected medicinal products (SMP) have been sold outside pharmacies without prescription since 1998. Medicinal products containing paracetamol and ibuprofen belong to this category among others. There were 2368 vendors of SMP in 2017 in the Czech Republic. Objectives: The main purpose of this thesis was to analyse time and local availability, financial affordability of SMP and to analyse safety of selling SMP outside pharmacies. Methods: The research was performed between 12th March 2018 and 16th March 2018 in regions: Chrudim, Hradec Kralove, Pardubice and Rychnov nad Kneznou. 50 vendors of SMP were selected from the database of State Institute for Drug Control regarding proportional representation on the market in the Czech Republic. Subject of research was a 24-year-old male demanding SMP to treat acute toothache. Obtained data were filled in a prepared form. Results were processed by means of descriptive statistics. Results: Time availability was increased, especially in gas stations. 97.6% of vendors had extended opening hours on...
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Selected Medicinal Products
Suchánek, David ; Kostřiba, Jan (advisor) ; Kolář, Jozef (referee)
Charles University, Faculty of Pharmacy in Hradec Kralove Department of Social and Clinical Pharmacy Student David Suchánek Supervisor PharmDr. Jan Kostřiba, Ph.D. Title of Diploma Thesis Selected medicinal products Introduction: According to market authorisation selected medicinal products (SMP) have been sold outside pharmacies without prescription since 1998. Medicinal products containing paracetamol and ibuprofen belong to this category among others. There were 2368 vendors of SMP in 2017 in the Czech Republic. Objectives: The main purpose of this thesis was to analyse time and local availability, financial affordability of SMP and to analyse safety of selling SMP outside pharmacies. Methods: The research was performed between 12th March 2018 and 16th March 2018 in regions: Chrudim, Hradec Kralove, Pardubice and Rychnov nad Kneznou. 50 vendors of SMP were selected from the database of State Institute for Drug Control regarding proportional representation on the market in the Czech Republic. Subject of research was a 24-year-old male demanding SMP to treat acute toothache. Obtained data were filled in a prepared form. Results were processed by means of descriptive statistics. Results: Time availability was increased, especially in gas stations. 97.6% of vendors had extended opening hours on...
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Non-prescribed antibiotic use in some developing countries and its association with drug resistance
Belkina, Tatiana ; Kolář, Jozef (advisor) ; Špliňo, Miroslav (referee) ; Tesař, Tomáš (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of Social and Clinical Pharmacy Candidate Tatiana Belkina, MSc Supervisor doc. RNDr. Jozef Kolář, CSc. Title of Doctoral Thesis Non-prescribed antibiotic use in some developing countries and its association with drug resistance Background and Aims: The global emergence and spread of antimicrobial resistance remain a major challenge to infection control and a predominant reason for therapy failure. Non-prescription access to antimicrobials is common, and self- prescribing is increasingly popular in a society with non-regulated access to antimicrobials. It is crucial to avoid self-medication in order to combat antimicrobial resistance. This research need has been addressed within 4 scientific projects with the following aims: P1: We examined knowledge, attitude and practices of antibiotic use in 3 Asian countries and estimated the frequency and reasons for self- medication. P2: This study aimed to evaluate the extent of delay in diagnosis and treatment of tuberculosis in Uzbekistan and identify associated risk factors. P3: To evaluate knowledge of antibiotics, race, gender and age as independent risk factors for self-medication. P4: The aim of this study was to assess the attitudes of community pharmacists regarding antibiotic use...
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Non-prescribed antibiotic use in some developing countries and its association with drug resistance
Belkina, Tatiana ; Kolář, Jozef (advisor) ; Špliňo, Miroslav (referee) ; Tesař, Tomáš (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of Social and Clinical Pharmacy Candidate Tatiana Belkina, MSc Supervisor doc. RNDr. Jozef Kolář, CSc. Title of Doctoral Thesis Non-prescribed antibiotic use in some developing countries and its association with drug resistance Background and Aims: The global emergence and spread of antimicrobial resistance remain a major challenge to infection control and a predominant reason for therapy failure. Non-prescription access to antimicrobials is common, and self- prescribing is increasingly popular in a society with non-regulated access to antimicrobials. It is crucial to avoid self-medication in order to combat antimicrobial resistance. This research need has been addressed within 4 scientific projects with the following aims: P1: We examined knowledge, attitude and practices of antibiotic use in 3 Asian countries and estimated the frequency and reasons for self- medication. P2: This study aimed to evaluate the extent of delay in diagnosis and treatment of tuberculosis in Uzbekistan and identify associated risk factors. P3: To evaluate knowledge of antibiotics, race, gender and age as independent risk factors for self-medication. P4: The aim of this study was to assess the attitudes of community pharmacists regarding antibiotic use...
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The Importance of Self-Reported Medication Adherence in the Evaluation of the Effectiveness of Pharmacotherapy
Ládová, Kateřina ; Matoulková, Petra (advisor) ; Červený, Petr (referee) ; Lukáš, Milan (referee) ; Kolář, Jozef (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Social and Clinical Pharmacy Candidate: Mgr. Kateřina Ládová Supervisor: PharmDr. Petra Matoulková, Ph.D.; PharmDr. Magda Vytřísalová, Ph.D. (Consultant) Title of Doctoral Thesis: The Importance of Self-Reported Medication Adherence in the Evaluation of the Effectiveness of Pharmacotherapy Introduction and Objective: Medication adherence (MA) is a highly variable factor affecting the response to the therapy. Especially in chronic disease, non-adherence presents a problem that may have health, social, and even economic consequences. Measuring MA is the most often performed by self-reported surveys which enables, among others, their simple application in research as well as in every day clinical practices. Self-reported MA monitoring may contribute to maximizing the effectiveness of pharmacotherapy and minimizing the risk of therapy failure, however, standardization of measuring process is needed. Moreover, some factors such as healthy adherer effect (HAE), which reflect patient health seeking behaviour but cannot be easily monitored, can favourably affect health outcomes. Acquired results may then be incorrectly attributed to drug therapy examined in the study. Hence, the main aims of this doctoral thesis were: 1) to...
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The Importance of Self-Reported Medication Adherence in the Evaluation of the Effectiveness of Pharmacotherapy
Ládová, Kateřina ; Matoulková, Petra (advisor) ; Červený, Petr (referee) ; Lukáš, Milan (referee) ; Kolář, Jozef (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Social and Clinical Pharmacy Candidate: Mgr. Kateřina Ládová Supervisor: PharmDr. Petra Matoulková, Ph.D.; PharmDr. Magda Vytřísalová, Ph.D. (Consultant) Title of Doctoral Thesis: The Importance of Self-Reported Medication Adherence in the Evaluation of the Effectiveness of Pharmacotherapy Introduction and Objective: Medication adherence (MA) is a highly variable factor affecting the response to the therapy. Especially in chronic disease, non-adherence presents a problem that may have health, social, and even economic consequences. Measuring MA is the most often performed by self-reported surveys which enables, among others, their simple application in research as well as in every day clinical practices. Self-reported MA monitoring may contribute to maximizing the effectiveness of pharmacotherapy and minimizing the risk of therapy failure, however, standardization of measuring process is needed. Moreover, some factors such as healthy adherer effect (HAE), which reflect patient health seeking behaviour but cannot be easily monitored, can favourably affect health outcomes. Acquired results may then be incorrectly attributed to drug therapy examined in the study. Hence, the main aims of this doctoral thesis were: 1) to...
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Pharmacies in Greece
Zacharakis, Georgios ; Kotlářová, Jana (advisor) ; Kolář, Jozef (referee)
PHARMACIES IN GREECE Author: Georgios Zacharakis Tutor: RNDr. Jana Kotlářová, Ph.D. Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Kralove, Charles University in Prague, Czech Republic Aim of diploma thesis: The aim is to get current facts and knowledge about the situation of pharmacies in Greece, including their basic problems, and to compare it with the Czech Republic. Methods: Data collection through appreciation of information and studying of literature, esp. Greek legislation. Results: It was given necessary information on the National Health System in Greece and about place and role of pharmacies in this. The main part of thesis deals wits pharmacies in Greece (legislation, statistics, pharmacists, activities in pharmacy). There are many private community pharmacies and low amount of hospital pharmacies which are only for inpatients. Both Greece and Czech Republic made considerable efforts in latest years to harmonize their legislation to the European standards. However, a significant difference between Greece and Czech Republic is profit margins of wholesalers, which are higher in the Czech Republic in comparison to Greece, while the production of drugs in Greece is significant higher than Czech Republic, which based more in its neighboring countries for the supply...
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Selected Organization and Association for Pharmacists in Greece
Papamichail, Christina ; Kotlářová, Jana (advisor) ; Kolář, Jozef (referee)
SELECTED ORGANIZATION AND ASSOCIATION FOR PHARMACISTS IN GREECE Author: Christina Papamichail Tutor: RNDr. Jana Kotlářová, Ph.D. Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Kralove, Charles University in Prague, Czech Republic Aim of study: The aim of Diploma thesis was to get current knowledge about the selected organizations and associations for pharmacists in Greece, especially about the Panhellenic Pharmaceutical Association (PFS), their role, interconnection and influence not only in the selected part of society such as pharmacists but in the society in Greece generally and to shortly compare the situation these vocational organizations in Greece and in Czech Republic. Methods: The data collection through appreciation of information from different reliable internet sources, Greek legislation, as well from discussion with members of PFS. The paper form of literature is for this topic limited. Results: The role of the PFS in Greece is the same vital as the role of Czech Chamber of Pharmacists in Czech Republic (CLNK). The most important difference between them is in membership. In Greece due to the difficult and strictly conditions in the field of economy the role of the chamber is essentially inactive in comparison with the CLNK. The reason of this inactivity is...
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