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Phantom model for perfusion imaging
Borovičková, Michaela ; Harabiš, Vratislav (referee) ; Mézl, Martin (advisor)
This work focuses on issues relating to the perfusion analysis. The aim of this work is to perform experimental measurements of the phantom and then evaluate the perfusion curves. This curves are used to himation of perfusion hemodynamic parameters, which indicates important informatik about monitoring area. All processes associated with the designation and evaluation are performed in a program named Matlab. The output of work is a system that provides the reader into the problem of perfusion analysis and allows him to understand and know what is the meaning od analysis, what demands are placed on the evaluation and what is the result of this perfusion analysis.
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Super-resolution methods
Franěk, Pavel ; Fedra, Petr (referee) ; Mézl, Martin (advisor)
The main goal of this bachelor’s thesis is acquaint with method, which enable increasing resolution digital photos. Also realize individual interpolation method and Super-resolution by the help of programme Matlab and reference on estimation record. Discuss possibility using method super- resolution for imagery with medical modality.
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EKG synchonization of electroporation pulses
Nohel, Michal ; Mézl, Martin (referee) ; Novotná, Veronika (advisor)
Bachelor thesis is focused on cells electroporation principle and its types. It further describes thermal and nonthermal ablation techniques with an emphasis on irreversible electroporation. It contains an overview of fields, where medical procedures in combination with ECG signal are used, and an overview of techniques and measurements of the electrocardiographic signal. Further, the sensitivity of the human body to electroporation pulses is discussed. During electroporation, short high-voltage pulses are applied. Ventricular fibrillation may occur if the electroporation pulse is applied to the vulnerable period of the heart rhythm. Synchronization of pulse application with heart activity of the patient is necessary for health and safety reasons in clinical practice. The practical part of the thesis is about a LabVIEW program for this kind of synchronization. The created program is tested and the obtained results achieved are evaluated in terms of practical use.
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Quantification of Relaxation Time T1 in DCE-MRI
Vitouš, Jiří ; Mézl, Martin (referee) ; Jiřík, Radovan (advisor)
This bachelor thesis deals with methods of T1 relaxation time quantification and B1 magnetic field inhomogeneities corrections. For purposes of the required measurements, the phantom was created using a 3D printer. Firstly the thesis presents information about a given theme, then it hands out the results of measurements taken using standard quantification methods. These methods are consequently analyzed and compared. Next part of the bachelor thesis deals with the fast method based on a variable flip angle (VFA), which needs a magnetic field B1 correction maps to give reasonable T1 estimates. For this purpose, two methods of B1 correction are presented. The first method is a double angle method and second is based on mapping magnetic field B1 using a reference T1 map. To decide which T1 map of which method should be used as a reference, a simple simulation is proposed, which describes the impact of unfavorable effects, such as B1 itself, on the T1 estimate of standard methods. In the end, the conclusions are made and the results of VFA methods are compared with standard methods of quantification.
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Sleep stages classification
Cikánek, Martin ; Mézl, Martin (referee) ; Potočňák, Tomáš (advisor)
The aim of this bachelor thesis was to elaborate a literature research on the topic of automatic classification of sleep stages from polysomnographic measurements and to subsequently select a way of feature extraction and quantitatively evaluate it. In the first part, the thesis deals mostly with the theory regarding the classification of sleep stages and analyzes the various possibilities of the process. This part is followed by a description of individual parts of the program, which is used for the extraction and subsequent quantitative evaluation of the features. The work is concluded by statistical evaluation of the results.
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Výuka zobrazovacích systémů na Ústavu biomedicínského inženýrství FEKT VUT v Brně
Mézl, Martin ; Jiřík, Radovan
Příspěvek pojednává o výuce zobrazovacích systémů v rámci studijních programů v oblasti biomedicínského inženýrství na Ústavu biomedicínského inženýrství FEKT VUT v Brně. V rámci jednotlivých kapitol je představeno zařazení předmětů do studijních plánů, jejich obsah a formy výuky. Další kapitola představuje dostupné přístrojové vybavení na pracovišti a jejich užití v laboratorních úlohách. Samostatná podkapitola je věnována také softwarové podpoře výuky a exkurzím na brněnských pracovištích, se kterými spolupracujeme.
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Spatial-temporal epidemiologic models of Covid-19
Schubert, Richard ; Ředina, Richard (referee) ; Mézl, Martin (advisor)
This work aims to establish a fundamental framework for studying spatially diffusive models that describe the dynamics of infectious disease spread with constant parameters in a homogeneous domain. Initially, compartmental models and their extension to spatial domains are examined, followed by the theory of metapopulation models, where the degree of coupling between populations and the overall reproductive number R0 is discussed. Furthermore, the relationship between R0 and the shape of the spatial distribution of infected individuals in a simple diffusive SIR model is modeled. The influence of Neumann boundary conditions versus Dirichlet boundary conditions on R0 is demonstrated. In the second part of the work, selected findings and conclusions of studies that applied models in the spatiotemporal domain to analyze and predict the COVID-19 pandemic are summarized. In the third part of the work, a model with diffusive and metapopulation elements is fitted to epidemiological data from Lombardy in 2020, and the suitability of this approach is discussed.
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Prediction of radiotherapy response in rectal cancer by MR
Chmela, Radek ; Nohel, Michal (referee) ; Mézl, Martin (advisor)
This diploma thesis deals with the issue of predicting the response of rectal cancer to radiotherapy. The work is divided into four chapters. In the first two, the anatomy of the rectum, types of cancer and individual diagnostic methods are described, together with algorithms for detecting objects in images. In the third chapter, there is a description of the solution for automatic segmentation and prediction of the effectiveness of radiotherapy. In the fourth chapter, the achieved results are discussed.
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