|
|
Influence of mixing conditions of microcrystalline celluloses with lubricants on compression process and tablet strength.
Mastná, Eliška ; Mužíková, Jitka (advisor) ; Šklubalová, Zdeňka (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department: Pharmaceutical Technology Student: Eliška Kučerová Consultant: Assoc. Prof. PharmDr. Jitka Mužíková, Ph.D. Title of the Diploma Thesis: Influence of mixing conditions of microcrystalline celluloses with lubricants on compression process and tablet strength. This work evaluates the influence of a type of mixing device and mixing time of three types of microcrystalline cellusoses (MCC) with lubricants on compression process and tablet strength. Microcel® MC 102, MC 200 and Prosolv® SMCC 90 are used as dry binders. Magnesium stearate and sodium stearyl fumarate at 1% concentration are used as lubricants. Two types of mixing devices are used to mix powders, a mixing cube and a 3D Turbula mixer. Mixing time is 2 or 4 minutes. All tablets are compressed by compression force of 5 kN on the Zwick / Roell T1-FRO 50 material tester. The compressibility is evaluated by the energy profile of compression process, sensitivity to the addition of lubricants is characterized by lubricant sensitivity ratio values (LSR). The total energy of compression of all MCC decreases with the addition of both types of lubricants and with longer mixing time, more in the case of mixing in the cube. The highest values of the total energy of compression and at...
|
|
|
A study of the influence of co-processed dry binder type on the properties of oraly disintegrating tablets with the drugs domperidone and lisinopril.
Jáglová, Kateřina ; Mužíková, Jitka (advisor) ; Šklubalová, Zdeňka (referee)
Charles University, Faculty of Pharmacy in Hradci Králové Department of: Pharmaceutical Technology Mentor: Assoc. Prof. PharmDr. Jitka Mužíková, Ph.D. Consultant: Mgr. Thao Tranová Student: Kateřina Jáglová Title of Thesis: A study of the influence of co-processed dry binder type on the properties of orally disintegrating tablets with the drugs domperidone and lisinopril The study deals with the influence of the type of co-processed dry binder on the compressibility of directly compressible tableting materials and the properties of orodispersible tablets containing the drugs domperidone and lisinopril. The tested co- processed dry binders are Ludiflash ® , Prosolv ® ODT G2 and Parteck ® ODT. The tablets further contain 1% sucralose as a sweetener and 1% magnesium stearate as a lubricant. The tablets are compressed by a compression force of 3 kN. The compressibility is evaluated by the energy profile of the compression process. Tensile strength, friability, wetting time, disintegration time, and porosity of tablets are tested. In the group of placebo, Parteck ® ODT showed the highest total energy of compression, whereas Prosolv ® ODT G2 showed the lowest values. The values of this energy decreased with the addition of drugs in all formulations, with domperidone having more significant effect....
|
|
|
A study of tableting materials and tablets with the retarding component containing hypromellose and carmellose sodium.
Koukolová, Kristýna ; Mužíková, Jitka (advisor) ; Šnejdrová, Eva (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department: Pharmaceutical Technology Student: Kristýna Koukolová Consultant: Assoc. Prof. PharmDr. Jitka Mužíková, Ph.D. Title of the Diploma Thesis: A study of tableting materials and tablets with the retarding component containing hypromellose and carmellose sodium The thesis deals with the study of compressibility of directly compressible tableting materials containing coprocessed dry binders MicroceLac® 100 and Prosolv® SMCC 90 in combination with the retarding component CompactCel® SR, which is a mixture of hypromellose and carmellose sodium. The tested concentrations of the retarding component were 10 %, 20 % and 30 %. The formulations also contained salicylic acid as a model drug at concentration of 25 % and sodium stearyl fumarate as a lubricant at concentration of 1%. Flow properties, specifically fowability, apparent volumes and densities were evaluated at the tableting materials. During tablet compression, compressibility was evaluated using the energy profile of the compression process. The tested tablet parameters were tensile strength, friability, disintegration and drug dissolution. Formulations with MicroceLac® 100 showed better flow properties. The addition of a retarding component worsened the flow properties. The values...
|
|
|
A study of the influence of co-processed dry binder type on the properties of oraly disintegrating tablets with the drugs ibuprofen and paracetamol.
Víšková, Michaela ; Mužíková, Jitka (advisor) ; Svačinová, Petra (referee)
Charles University, Faculty of Pharmacy in Hradci Králové Department of: Pharmaceutical Technology Mentor: Assoc. Prof. PharmDr. Jitka Mužíková, Ph.D. Consultant: Mgr. Thao Tranová Student: Michaela Víšková Title of Thesis: A study of the influence of co-processed dry binder type on the properties of orally disintegrating tablets with the drugs ibuprofen and paracetamol. This thesis deals with the study of orally disintegrating tablets containing co-processed dry binders Ludiflash® , Prosolv® ODT G2 and Parteck® ODT with analgesics ibuprofen and paracetamol. The tablets also include magnesium stearate as a lubricant and sucralose as a sweetener at a concentration of 1%. The energy profile of the compression process, tablet tensile strength, friability, porosity, wetting time, water absorption ratio and disintegration time of the tablets are evaluated. Tableting material with Prosolv® ODT G2 shows the lowest value of pre-compression energy, drugs increase it. Furthermore, it shows the highest value of compression energy that drugs reduce. Prosolv® ODT G2 and Parteck® ODT placebo tablets have higher tensile strength than Ludiflash® placebo tablets. Drugs reduce tablet tensile strength, paracetamol more significantly. Placebo tablets meet the requirement for friability (up to 1 %), whereas in the case...
|
|
|
Formulation and characterization of w/o emulsions for local treatment of musculoskeletal infections
Vedralová, Štěpánka ; Šnejdrová, Eva (advisor) ; Mužíková, Jitka (referee)
CHARLES UNIVERSITY Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical technology Author: Štěpánka Vedralová Title of diploma thesis: Formulation and characterization of w/o emulsions for local treatment of musculoskeletal infections Supervisor: PharmDr. Eva Šnejdrová, Ph.D. The aim of the diploma thesis was to formulate a depot dosage form for the prevention and local treatment of musculoskeletal infections. A water-in-oil emulsions have been formulated which, due to the partition coefficient between the outer and inner phases, can provide sustained drug release. Oils with different viscosities were tested as oil phases. Tricaprin was chosen for the preparation of emulsions, due to the highest stability of the prepared emulsion. Lecithin and sorbitan monooleate or polyglyceryl-3-polyricinooleate (PGPR) and magnesium stearate were used as emulsifiers. The aqueous phase was a solution of vancomycin hydrochloride and gentamicin sulphate. The flow properties on a rotational rheometer were evaluated. The influence of the emulsion composition and the homogenization method on the coefficient of consistency and the index of flow behaviour of the emulsions was studied. The emulsions stabilized with lecithin have a higher viscosity and a structure more sensitive to changes in composition...
|
|
|
A study of the influence of co-processed dry binder type on the properties of oraly disintegrating tablets with the drugs domperidone and lisinopril.
Jáglová, Kateřina ; Mužíková, Jitka (advisor) ; Šklubalová, Zdeňka (referee)
Charles University, Faculty of Pharmacy in Hradci Králové Department of: Pharmaceutical Technology Mentor: Assoc. Prof. PharmDr. Jitka Mužíková, Ph.D. Consultant: Mgr. Thao Tranová Student: Kateřina Jáglová Title of Thesis: A study of the influence of co-processed dry binder type on the properties of orally disintegrating tablets with the drugs domperidone and lisinopril The study deals with the influence of the type of co-processed dry binder on the compressibility of directly compressible tableting materials and the properties of orodispersible tablets containing the drugs domperidone and lisinopril. The tested co- processed dry binders are Ludiflash ® , Prosolv ® ODT G2 and Parteck ® ODT. The tablets further contain 1% sucralose as a sweetener and 1% magnesium stearate as a lubricant. The tablets are compressed by a compression force of 3 kN. The compressibility is evaluated by the energy profile of the compression process. Tensile strength, friability, wetting time, disintegration time, and porosity of tablets are tested. In the group of placebo, Parteck ® ODT showed the highest total energy of compression, whereas Prosolv ® ODT G2 showed the lowest values. The values of this energy decreased with the addition of drugs in all formulations, with domperidone having more significant effect....
|
|
|
Dosing of veterinary eye drops 2.
Chrapčiaková, Barbora ; Šklubalová, Zdeňka (advisor) ; Mužíková, Jitka (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of: Pharmaceutical Technology Consultant: doc. PharmDr. Zdeňka Šklubalová, Ph.D. Student: Barbora Chrapčiaková Title of Thesis: Dosing of veterinary eye drops 2. In this thesis, the mass of veterinary eye drops for chicken vaccination was evaluated. Drops were produced either by conventional dosing system or by new developed dropper device (semi-automatic). The influence of dosing rate, dispensing angle (90ř, 65ř, 45ř) and volume of liquid (5 - 30 ml) on the mass of eye drop was investigated. The higher dosing rate resulted in the increase in drop mass. The influence of dosing rate on the mass of drop was significant (p < 0.01) for both dispensing systems. The drop mass decreased with the decrease in the dispensing angle using manual dosing system if the eye dropper tip was not wetted, with the wetted one, the drop mass increased in comparison to vertical dropping. Due to the construction of the dropper device, the influence of dispensing angle was not evaluated, however, the wetting of dropper tip was not observed thanks to defined perimeter. The reduction in the remaining preparation volume led to the decrease in drop weight, particularly with simultaneous dispensing angle decrease, the effect was not significant.
|
|
|
A study of compressiblity and properties of tablets from coprocessed dry binder with manntol and croscarmellose sodium for orodispersible tablets.
Kamarýtová, Martina ; Mužíková, Jitka (advisor) ; Šklubalová, Zdeňka (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department: Pharmaceutical Technology Student: Martina Kamarýtová Consultant: PharmDr. Jitka Mužíková, Ph.D. Title of the Diploma Thesis: A study of compressibility and properties of tablets from coprocessed dry binder with mannitol and croscarmellose sodium for orodispersible tablets. This thesis deals with the study of directly compressible tableting materials and tablets with Parteck® ODT, which is designed for orodispersible tablets. The effect of three lubricants on the properties of tableting materials and tablets is evaluated. Tested lubricants are magnesium stearate, calcium stearate and sodium stearyl fumarate in concentrations of 0,5 and 1 %. Flow properties, compressibility, ejection force, tensile strength and disintegration time of tablets are tested. The compressibility is evaluated by the energy profile of compression process. Lubricants did not improve the flowability of Parteck® ODT. The total energy of compression increased with compression force and highest values were at the tableting material with 0,5 % magnesium stearate. The values of plasticity decreased with compression force, highest values were at the tableting material with 0,5 % sodium stearyl fumarate. The ejection force increased with compression force, the...
|
|
|
A study of the compressibility and properties of tablets from co-processed dry binders composed of two types of lactose and glyceryl monostearate.
Holubová, Kateřina ; Mužíková, Jitka (advisor) ; Šnejdrová, Eva (referee)
The thesis evaluated and compared the strength and disintegration time of tablets and the energy profile of compression in dependence on compression force in the co-processed dry binders LubriTose™ SD and LubriTose™ AN. These substances were further compared in these parameters with the physical mixtures of the pertinent lactoses with various lubricants in a concentration of 2 % and 4 %. The lubricants employed included glycerol monostearate, magnesium stearate, poloxamer 407, and sodium stearylfumarate. LubriTose™ AN yielded stronger tablets with a longer disintegration time, lower values of total energy and lower plasticity than LubriTose™ SD. The tablets made of LubriTose™ SD possessed the same strength as the tablets made of a physical mixture of spray-dried lactose with 4 % of poloxamer 407, but a higher one than those made of a mixture of lactose with of 4 % glycerol monostearate, and their disintegration time was longer, excepting the tablets made of a mixture with 4 % of magnesium stearate. The tablets made of LubriTose™ AN possessed the same strength and a longer disintegration time than the tablets made of a physical mixture of anhydrous lactose with 4 % of glycerol monostearate, and their disintegration time was identical with that of the tablets made of a physical mixture of the...
|
|
|
A study of the compressibility and properties of tablets from co-processed dry binder composed of microcrystalline cellulose and glyceryl monostearate.
Muchová, Sandra ; Mužíková, Jitka (advisor) ; Ondrejček, Pavel (referee)
The paper studies the co-processed dry binder LubriTose™ MCC from the viewpoint of energy evaluation of the compression process, strength and disintegration time of tablets. The results were compared with the identical evaluation of physical mixtures of microcrystalline cellulose with several types of lubricants. LubriTose™ MCC showed the lowest value of energy for friction, the highest value of energy accumulated by the tablet, and the highest plasticity of all tableting materials under study. There were no marked differences in the values of the energy of decompression. The tensile strength of tablets from LubriTose™ MCC was lower than in those from the mixture of Vivapur® 12 and glycerol monostearate, in the compression forces of 4 and 5 kN it was comparable with the tensile strength of tablets from Vivapur® 12 with poloxamer 407. Disintegration time of tablets from LubriTose™ MCC was shorter than that of those from Vivapur® 12 with glycerol monostearate at the compression force of 3 kN, in the case of the compression forces of 4 and 5 kN no statistically significant difference was found between the values of these tableting materials.
|
guest ::
