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Novel conformationally locked nucleosides and nucleotides based on bicyclo[3.2.1]octane scaffold as a pseudosugar moiety
Šála, Michal ; Dejmek, Milan ; Procházková, Eliška ; Hřebabecký, Hubert ; Rybáček, Jiří ; Dračínský, Martin ; Novák, Pavel ; Rosenbergová, Šárka ; Fukal, J. ; Sychrovský, Vladimír ; Rosenberg, Ivan ; Nencka, Radim
A route to a series of novel carbocyclic nucleosides locked in North conformation with bicyclo[3.2.1]octane scaffold was developed. Prepared nucleosides served as a starting material for the synthesis of modified oligomers [d(GCATATCAC), r(GCAUAUCAC), and A9]. Biological effects of the prepared nucleosides as well as the hybridization properties of the appropriate duplexes were evaluated.
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Influence of Physicochemical Factors on Gushing Mechanism
Poštulková, Michaela ; Novák, Pavel ; Vitoušová, K. ; Brányik, T. ; Růžička, Marek
Gushing is a negative phenomenon when a foam spontaneously gush out when a bottle or can is opened. Despite a long-term research the gushing still has not been fully explained. The problem of gushing is its seasonal variability, depending on the raw materials and processing technology. In addition, gushing intensity may change over the years. Furthermore, gushing also related to the fact that there is no simple and inexpensive method for measuring. The aim of this work was to find a suitable gushing matrix which could be helpful to study gushing in a new experimental pressure equipment. Simple and inexpensive apparatus was built for the study of overfoaming beer. The valve system (placed on the pressure equipment) control outlet/inlet gas and liquid phase. The pressure and temperature sensors can be also connected to the equipment. It is also possible to regulate the rate of decrease gas pressure above the liquid - the sudden reduction ideally simulates the classic opening beer bottles. A model solution of gushing liquid was created and the influence of the temperature, pressure and pH on the intensity of gushing was measured.
Fulltext: content.csg -  PDF
Plný tet: SKMBT_C22013110513040 - PDF
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Space and tectonics in musical
Pálka, Tomáš ; Slavický, Milan (advisor) ; Kopelent, Marek (advisor) ; Loudová, Ivana (referee) ; Novák Zemek, Pavel (referee)
Submitted thesis is a result of searching for relationships between music and space, between musical parameters and acoustical features of halls and objects for musical
production. Throughout the history of music present a number of works have been
composed which reflect a character of a particular space. The space is directly
reflected in their tectonic structure or instrumentation.
Twentieth century brought about an important change in perception of influences of
the space on the listener. Within this context emerged collaborations between
composers and architectures such as the cooperation on the Philips pavilion in
Brussels between composer Edgard Var?se and architect Le Corbusier. Iannis
Xenakis composer and architect in one person projects later the building Polyptops in
Montréal. An important role in this change of perception has played the interest in the
electro acoustical music from the fifties of the twentieth century onwards. The
acoustic properties of architecture and acoustic phenomena within electro acoustic
music form the basis of this thesis. It surveys the use of the principles of echo,
reverberation, clarity, as well as flutter echo or ?reverse? of reverberation within these
compositions. The analyses of these primary and derived acoustic phenomena in
musical piece form the focus of this thesis.
Whole thesis is divided into two main parts: First part describes acoustic properties
of halls utilized in music and the principles of creating of a space with particular
acoustic properties as described in a theory of building. Several conceptual types of
space are distinguished here.
Second part analyses selected compositions from the point of view of incorporating
the space or spatial principles within its musical tectonics. Historical compositions
from Lasso, Gabrieli, Tallis, Vivaldi?, but above all twentieth century compositions of
Ives, Martinů, Kopelent or Nono are analyzed. Analyses are chosen that way to have
such spectrum of pieces which are different in ways of working with space but which
can simultaneously be complementary one to the other. This part also summarizes
findings from analyzed compositions which are sorted by given phenomena.
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The Impacts of Financial Crisis on the Stock Exchange Markets
Novák, Pavel ; Veselá, Jitka (advisor) ; Polák, Michal (referee)
The diploma thesis deals with the impacts of financial crises, especially into the U.S. and European stock exchange market and the real economy. Contains the analysis of the Great Depression and the current economic downturn which follows the financial crisis of 2007 - 2008 from the perspective of the New York Stock Exchange index (DJIA) and the FTSE index of London Stock Exchange, as well as from the perspective of macroeconomic variables such as real GDP growth, the rate of unemployment and the industrial production index. The similarities and the specific features of the causes of their formation, the reactions of the monetary and legislative authorities, the impact on the stock exchange markets, regulatory implications and impact on the real economy are mentioned as a result of the detailed comparison of the two crises. The thesis includes prove to the hypothesis of higher volatility on the stock exchange markets during the crises periods on the daily data by calculating the variance and standard deviation.
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