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The influence of belinostat inhibition on the activity of selected reductases from AKR and SDR superfamilies.
Slámová, Adéla ; Wsól, Vladimír (advisor) ; Macháček, Miloslav (referee)
Charles University Faculty of Pharmacy in Hradec Králové Department of Biochemical Sciences Candidate: Bc. Adéla Slámová Supervisor: prof. Ing. Vladimír Wsól, Ph.D. Title of diploma thesis: The influence of belinostat inhibition on the activity of selected reductases from AKR and SDR superfamilies Anthracycline antibiotics (ANTs) are important antineoplastic agents. One of them, daunorubicin (DAUN), is used for the treatment of acute leukaemia and other malignancies in children and adults. Factors limiting its clinical use include mainly resistance and cardiotoxicity. Enzymes from aldo-keto reductase (AKR) and short-chain dehydrogenase/reductase (SDR) superfamilies mediated the reduction of DAUN to its C-13 alcohol metabolite daunorubicinol (DAUNOL). The metabolite is more cardiotoxic, less antineoplastic, and is causing anthracycline resistance. This diploma thesis aimed to examine the inhibitory effect of belinostat on the activity of AKR1A1, 1B1, 1B10, 1C3, and CBR1. The specific enzyme activity and inhibitory potential were estimated in vitro using recombinant enzymes, and the enzymatic production of DAUNOL was evaluated by the liquid chromatography (UHPLC) system. The inhibition was decreased in order AKR1C3 AKR1B10 AKR1A1 AKR1B1 CBR1. The most inhibited enzyme, AKR1C3, expressed 50,7%...
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The effect of mineral water consumption on the cardiovascular system and sports performance
Marek, Max ; Slámová, Alena (advisor) ; Kudlová, Eva (referee)
The bachelor's thesis discusses mineral waters from a natural or healing mineral source. The first part of the work deals with the importance of fluids for the human organism with an emphasis on the importance for athletes. It deals with essential aspects not only in terms of quantity but above all the quality of the fluids we drink. Legislation regarding bottled waters and healing mineral waters is mentioned here. The following part of the work is a list of natural mineral waters and healing mineral waters that are on the market in the Czech Republic. The work continues with information on consumer behavior, including a chapter on possible health benefits for regular consumers. An important part of the work is also the evaluation of the significance of the individual minerals contained in these waters (sodium, potassium, magnesium, calcium, chlorine and fluorine) and their effects in the human body, deficiency conditions for these ions and the content of these ions in specific mineral waters. The importance of mineralization of water intake for athletes is also discussed there with more details. The practical part of the work, is in the form of a short questionnaire. The practical part tried to find out what the athletes' knowledge is about the influence of the drinking regime and the quality of...
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Contract for work in the field of construction
Slámová, Anna ; Macková, Alena (advisor) ; Pohl, Tomáš (referee)
Guardianship in inheritance proceedings Abstract The presented diploma thesis deals with "guardianship in inheritance proceedings". The thesis aims to evaluate the meaning and purpose of the institute of guardianship focused on inheritance proceedings, to describe its legislation and relevant jurisprudence, and answer the question of whether the current legislation on guardianship provides sufficient protection to the rights and interests of persons under special protection participating in court proceedings. The thesis consists of five parts, including an introduction and a conclusion. The first part focuses on inheritance proceedings, its legal regulation, sources, and the proceedings in the context of the legal system. Inheritance proceedings are defined as non-disputed proceedings, and a comparison between non-disputed and disputed proceedings is also given. This part explains the court's jurisdiction, the preconditions, the proceedings' initiation, and the notary's role as a court commissioner. The course of the entire inheritance proceedings and the decisions issued in the proceedings are also described. In the second part, the participation in civil court proceedings is discussed. A general explanation of procedural entities, preconditions for participation such as procedural capacity and capacity to...
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Proposal for Changes of Motivational Programme in a Selected Company.
Slámová, Anežka ; Bednářová, Markéta (referee) ; Petrová, Kateřina (advisor)
In this bachelor's thesis, the author focuses on the analysis of the status and proposal of changes to the motivational program in the selected company. The work is divided into three main chapters. The theoretical part contains definitions of the basic areas of motivation, employee care, employee remuneration and employee benefits. The analytical part of the work describes the selected company and analyzes the current state of the motivational program using selected research methods. The last part then contains its own suggestions for improvement based on the analytical part of the work.
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Design of a Production Planning Support in the Information System
Slámová, Aneta ; Kurucová, Šárka (referee) ; Videcká, Zdeňka (advisor)
The topic of my bachelor thesis is the proposal of production planning support in the information system of the company SIK METAL s.r.o. with the focus on software support of processes. It deals with the creation of a proposal to improve the production planning with the support of the company information system, based on the analysis of the current state of production management in the given company and their evaluation. The first part contains the theoretical background for my work. The second, analytical part, deals with the introduction of the company SIK METAL, s.r.o. and the analysis of the chosen processes in the company. The third part contains my own proposal of production planning support in the information system of the company together with the actual evaluation of the proposal.
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Risk Analysis of a Weldment Production Process
Slámová, Aneta ; Kurucová, Šárka (referee) ; Blecha, Petr (advisor)
This diploma thesis is focused on the risk analysis of a selected production process of the company SIK METAL s.r.o. The work is divided into three parts, the theoretical part, then the analysis of the current state and the design part. The theoretical part defines the basic concepts that relate to risks. These theoretical findings are then applied in the second part of the work, where risk identification is performed using various types of analysis. Based on selected analyzes, proposals and recommendations are proposed in the final part of the diploma thesis. Proposals and recommendations contain financial quantifications.
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Inanimate Links
Slámová, Anna ; Janoščík,, Václav (referee) ; Zálešák, Jan (advisor)
"... The above-mentioned issues for me personally created the idea of a world in which the human race ceases to exist in the form of civilization known to us, and it is transformed back to its original collective consciousness, something that is "above" -above real physical presence, beyond basic animal processes , well above the world he created for himself, and through that killed himself. Through advanced technology and ultramodern materials, as well as minerals and vitamins, which arose from the original ancient building units, transforming the world into a new form of being. Remains of human existence in the form of countless objects and materials, which finally adapted to other forms of life (not already poisoned and weakened, but instead upgraded units) have gradually become the basic building block posthuman planetary culture. Archaeological site with an area of 510.1 million square kilometers slowly melt away in their embedded meanings and emotions seeped into polyvinyl chloride, which eventually engulfed simple cell clusters..."
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Walking training within Proprioceptive neuromuscular facilitation concept in stroke patients. ; Influencing of the Mid-Stance phase of stride
Nováková, Jana ; Slámová, Adéla (advisor) ; Balíková, Tereza (referee)
OF BACHELOR THESIS Name, surname: Jana Nováková Supervisor: Ing. Adéla Slámová Consultant: Mgr. Jakub Kozel Title: Walking training within Proprioceptive neuromuscular facilitation concept in stroke patients Subtitle: Influencing of the Mid-Stance phase of stride Abstract: The topic of the bachelor's thesis is the training of walking in patients after a stroke. This acquired non-traumatic brain damage represents the second most common non-traumatic cause of death in today's modern civilization, in the Czech Republic the incidence of this disease is around 300 cases/100,000 inhabitants. The consequences of a stroke are usually numerous, and one of the resulting disorders can be hemiparetic walking with spasticity. The theoretical part includes four main chapters. The first section is devoted to the description of a commonly occurring non-traumatic brain injury, namely the description of a stroke. The second chapter describes stereotype, kinesiology and gait analysis. The third chapter includes a description of the philosophy of Proprioceptive neuromuscular facilitation (PNF), basic concepts and principles of the concept, PNF therapy of hemiparetic gait and summarizes the issue of spasticity in PNF therapy. In the last section, walking tests for patients after a stroke, their use and application in...
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Stimulation of swallowing within PNF concept in patients with acquired brain injury
Matys, Václav ; Slámová, Adéla (advisor) ; Fabičovic, Klaudia (referee)
BACHELOR THESIS ABSTRACT Name, surname: Václav Matys Supervisor: Ing. Adéla Slámová Consultant: Ing. Mgr. Jana Horynová Title: Stimulation of swallowing within PNF concept in pacient with acquired brain injury A swallowing disorder often occurs as a complication in acquired brain injury diagnosis. In more serious cases it can constitute even life-threatening condition, primarily due to the risk of aspiration and possilbe subsequent development of an inflammatory lung disease. This thesis deals with a possibility of therapeutic influencing of neurogenic dysphagia with utilization of elements of the concept of proprioceptive neuromuscular facilitation - PNF. Contrary to the fact that exercise on the PNF basis to influence dysphagia isn't used frequently in clinical practice, it represents highly effective and for the therapist easily managable method of therapy. The practical part contains a case history of patients with dysphagia, to whom the therapy on the PNF basis was applied. The goal of the bachelor thesis is to create an educative material for a community of experts, particularly physiotherapist as well as speech pathologists or occupational therapists, and thus support interdisciplinary cooperation in the care of dysphagia patients. The result of the thesis is a formation of the therapeutic procedure...
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