Original title: Role of extracellular adenosine in Drosophila
Translated title: Role of extracellular adenosine in Drosophila
Authors: FENCKOVÁ, Michaela
Document type: Doctoral theses
Year: 2011
Language: cze
Abstract: This thesis describes several aspects of the role for extracellular adenosine in Drosophila. Reverse genetic, molecular and microscopic methods together with the most forefront Drosophila research techniques have been applied to elucidate the role of adenosine signaling in the regulation of development, physiology and metabolism of Drosophila larvae. The thesis helps to establish the model for extracellular adenosine as a stress-signal for the release of energy stores. It also describes the elucidation of Drosophila extracellular adenosine production pathway by functional characterization of extracellular ATP/adenosine converting enzymes. Further, this thesis describes the attempt to study adenosine signaling by creation of tissue specific knock-down mutation of Drosophila adenosine receptor. Finally, it provides results of the utilization of in vivo fluorescent reporters for studying of the localization, function and interaction of enzymes implicated in adenosine signaling pathway.
Keywords: adenosine; drosophila; ekto-5'-nucleotidases; glucose metabolism; in vivo reporters; adenosine; drosophila; ekto-5'-nucleotidases; glucose metabolism; in vivo reporters
Citation: FENCKOVÁ, Michaela. Role of extracellular adenosine in Drosophila. České Budějovice, 2011. disertační práce (Ph.D.). JIHOČESKÁ UNIVERZITA V ČESKÝCH BUDĚJOVICÍCH. Přírodovědecká fakulta

Institution: University of South Bohemia in České Budějovice (web)
Document availability information: Fulltext is available in the Digital Repository of University of South Bohemia.
Original record: http://www.jcu.cz/vskp/6166

Permalink: http://www.nusl.cz/ntk/nusl-81283


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Universities and colleges > Public universities > University of South Bohemia in České Budějovice
Academic theses (ETDs) > Doctoral theses