Original title: The role of adenosine signaling pathway in regulation of metabolic reserves
Translated title: The role of adenosine signaling pathway in regulation of metabolic reserves
Authors: OKROUHLÍKOVÁ, Monika
Document type: Doctoral theses
Year: 2012
Language: cze
Abstract: This thesis presents a study of possible role of the extracellular adenosine signaling pathway in the regulation of metabolism of energetic reserves in Drosophila melanogaster. I focus on a study of metabolism of carbohydrate reserves and show a connection of adenosine signaling pathway to regulation of glucose homeostasis. Results of hemolymph and whole larval and pupal carbohydrates concentration measurements are shown together with concentration of other metabolites. They suggest that glucose homeostasis is impaired in the adgf-a mutant, which is accompanied by impaired metabolism of energetic reserves. The work is based on genetic screening for dominant suppressors of larval lethality caused by a loss of function mutation in the main larval adenosine deaminase, ADGF-A. Possible interactions of adenosine signaling pathway and regulation of immune response are disscussed.
Citation: OKROUHLÍKOVÁ, Monika. The role of adenosine signaling pathway in regulation of metabolic reserves. České Budějovice, 2012. disertační práce (Ph.D.). JIHOČESKÁ UNIVERZITA V ČESKÝCH BUDĚJOVICÍCH. Přírodovědecká fakulta

Institution: University of South Bohemia in České Budějovice (web)
Document availability information: Fulltext is available in the Digital Repository of University of South Bohemia.
Original record: http://www.jcu.cz/vskp/6165

Permalink: http://www.nusl.cz/ntk/nusl-81282


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Universities and colleges > Public universities > University of South Bohemia in České Budějovice
Academic theses (ETDs) > Doctoral theses