Original title: Evolution of the tetrapyrrole synthesis in eukaryotes
Translated title: Evolution of the tetrapyrrole synthesis in eukaryotes
Authors: KOŘENÝ, Luděk
Document type: Doctoral theses
Year: 2011
Language: cze
Abstract: This thesis focuses on the nature of heme metabolism in various eukaryotes. One of the aims was the elucidation of the origin of the unique heme biosynthesis pathway in apicomplexan parasites through a comparative study of their photosynthetic relative Chromera velia combining molecular biology, biochemistry and bioinformatics approach. Using similar strategy, I have also investigated the origin and spatial organization of tetrapyrrole biosynthesis in Euglena gracilis. Based on the phylogenetic data I described the complex evolution of heme metabolism in kinetoplastid flagellates including pathogenic trypanosomes. I revealed that one of them (Phytomonas) does not require heme for viability by the combination of various biochemical and molecular biology experiments and bioinformatic analyses.
Keywords: Endosymbioses; Eukaryotes; Evolution; Heme synthesis; Parasites; Tetrapyrrole pathway; Endosymbioses; Eukaryotes; Evolution; Heme synthesis; Parasites; Tetrapyrrole pathway
Citation: KOŘENÝ, Luděk. Evolution of the tetrapyrrole synthesis in eukaryotes. České Budějovice, 2011. disertační práce (Ph.D.). JIHOČESKÁ UNIVERZITA V ČESKÝCH BUDĚJOVICÍCH. Přírodovědecká fakulta

Institution: University of South Bohemia in České Budějovice (web)
Document availability information: Fulltext is available in the Digital Repository of University of South Bohemia.
Original record: http://www.jcu.cz/vskp/7617

Permalink: http://www.nusl.cz/ntk/nusl-71435


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Universities and colleges > Public universities > University of South Bohemia in České Budějovice
Academic theses (ETDs) > Doctoral theses