Original title: Role of submembrane spaces in the control of transmembrane ion flux and cellular inotropic state in a model of human ventricular cardiomyocyte
Authors: Pásek, Michal ; Bébarová, M. ; Christé, G.
Document type: Papers
Conference/Event: Engineering mechanics 2024 /30./, Milovy (CZ), 20240514
Year: 2024
Language: eng
Abstract: We have recently developed a model of a human ventricular cardiomyocyte incorporating the t-tubular and surface submembrane spaces and restricted ion exchange between these spaces and cytosol. After incorporating the experimental finding that the majority of Na+-Ca2+ exchanger proteins are located at the t-tubular membrane of human ventricular cardiomyocytes, we explored the consequences of ion concentration changes in the submembrane spaces on the electrophysiological activity of these cells. Consistently with published experimental and modelling studies, our model predicts an increased Ca2+ extrusion during the action potential. However, our model also predicts a significant reduction of Ca2+ extrusion throughout the diastole, which can ultimately lead to an increase in cellular inotropy.
Keywords: human ventricular cardiomyocyte; mathematical model; sodium-calcium exchanger; submembrane Ca2+ gradient; submembrane spaces; t-tubules
Host item entry: Engineering mechanics 2024. Book of full texts, ISBN 978-80-214-6235-9, ISSN 1805-8248

Institution: Institute of Thermomechanics AS ČR (web)
Document availability information: Fulltext is available at external website.
External URL: www.engmech.cz/improc/2024/230.pdf
Original record: https://hdl.handle.net/11104/0356050

Permalink: http://www.nusl.cz/ntk/nusl-651683


The record appears in these collections:
Research > Institutes ASCR > Institute of Thermomechanics
Conference materials > Papers