Název: Thin Nanostructured Film with Bioapplication Potential
Autoři: KUMAR, Sanjay
Typ dokumentu: Disertační práce
Rok: 2024
Jazyk: eng
Abstrakt: The Ph.D. thesis aims to investigate, develop, and fabricate advanced nanostructured surfaces for (bio)sensors and detection applications. The primary outcome of the research is the development of a functional sensor transducer for the detection of specific anti-DbpA antibodies, typically produced by a living organism in response to Lyme disease infection, as well as for detecting live Borreliosis pathogens. The developed sensor is based on AgNPs/C:H:N:O plasma polymer nanocomposites. Silver (Ag) nanoparticles, generated by a gas aggregation source, are incorporated into a C:H:N:O plasma polymer matrix, which is deposited by magnetron sputtering of nylon 6.6. The surface of the AgNPs/C:H:N:O nanocomposite is functionalized with amino-rich -NH2 grafts and specific antibodies to achieve high specificity in detection. Anchored Ag nanoparticles propagate localized surface plasmon resonance (LSPR), optically responding to changes caused by immobilized targets near the nanoparticles. The sensitivity of the sensor transducer is enhanced by incorporating Cu nanoparticles, which contribute to Cu-Ag coupling modes responsible for the modulation of the LSPR bands. The achieved results pave the way for rapid, low-cost, sensitive platforms for detecting not only the antibodies/pathogens studied here but also potentially other targets.
Klíčová slova: adhesion; annealing; antibacterial; Borrelia; C:H:N:O thin film; Cu); enhanced detection; immobilization; localized surface plasmon resonance (LSPR); Lyme disease; magnetron sputtering; nanocomposite; nanoparticles (Ag; nanostructures; nylon; plasma polymer; plasma polymerization; plasma-assisted deposition; plasmonic absorption; sensors; surface functionalization
Citace: KUMAR, Sanjay. Thin Nanostructured Film with Bioapplication Potential. České Budějovice, 2024. disertační práce (Ph.D.). JIHOČESKÁ UNIVERZITA V ČESKÝCH BUDĚJOVICÍCH. Přírodovědecká fakulta

Instituce: Jihočeská univerzita v Českých Budějovicích (web)
Informace o dostupnosti dokumentu: Plný text je dostupný v digitálním repozitáři JČU.
Původní záznam: http://www.jcu.cz/vskp/59343

Trvalý odkaz NUŠL: http://www.nusl.cz/ntk/nusl-651523