Nanomaterials as a platform for the doxorubicin transport - Fluorescence imaging

Blažková, Iva

Doxorubicin (DOX) is an important anthracycline antineoplastic drug used to treat a variety of cancers. As well as other antineoplastic agents, DOX has negative side effects; the most serious one is cardiotoxicity. Conjugation of DOX with nanomaterials could help to reduce its adverse effects. The presented thesis entitled ,,Nanomaterials as a platform for the DOX transport -- Fluorescence imaging" is primarily focused on the study of DOX interaction with biomolecules such as amino acids and albumin. The interaction was analysed by fluorescence spectrometry and by other analytical methods and significant interaction with amino acids as well as with protein albumin was detected. Next work was focused on the utilization of nanoparticles in DOX transport. DOX was conjugated with fullerenes or encapsulated in liposomes and properties of these nanoconstructs, in vitro and in vivo, were analysed. Both of these nanomaterials seemed to be good nanotransporters for DOX targeted delivery.

host :: přihlásit Digitální repozitář
		Hledej		Nový záznam		Nápověda		O repozitáři